Cannabis Compound Database: Showing Protein Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform (CDBP03163)

Identification Biological properties Gene properties Protein properties External links References XML Show 2 compounds

Identification

HMDB Protein ID

CDBP03163

Secondary Accession Numbers

Not Available

Name

Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform

Description

Not Available

Synonyms

CAM-PRP catalytic subunit
Calmodulin-dependent calcineurin A subunit beta isoform

Gene Name

PPP3CB

Protein Type

Enzyme

Biological Properties

General Function

Involved in hydrolase activity

Specific Function

Calcium-dependent, calmodulin-stimulated protein phosphatase. This subunit may have a role in the calmodulin activation of calcineurin.

GO Classification

Biological Process
axon extension
calcium ion-dependent exocytosis
signal transduction
negative regulation of T cell mediated cytotoxicity
muscle cell homeostasis
T cell proliferation
cellular response to drug
protein dephosphorylation
positive regulation of insulin secretion involved in cellular response to glucose stimulus
response to amphetamine
heart development
social behavior
memory
positive regulation of transcription, DNA-dependent
T cell differentiation
regulation of synaptic plasticity
protein phosphorylation
learning
T cell homeostasis
response to cytokine stimulus
Cellular Component
cytosol
plasma membrane
calcineurin complex
Function
catalytic activity
hydrolase activity
Molecular Function
calcium ion binding
drug binding
calmodulin-dependent protein phosphatase activity
protein phosphatase 2B binding
calmodulin binding

Cellular Location

Cytoplasmic

Pathways

Name	SMPDB/Pathwhiz	KEGG
MAPK signaling pathway	Not Available
Calcium signaling pathway	Not Available
Oocyte meiosis	Not Available
Apoptosis	Not Available
Wnt signaling pathway	Not Available

Gene Properties

Chromosome Location

Locus

10q22.2

SNPs

PPP3CB

Gene Sequence

>1575 bp
ATGGCCGCCCCGGAGCCGGCCCGGGCTGCACCGCCCCCACCCCCGCCCCCGCCGCCCCCT
CCCGGGGCTGACCGCGTCGTCAAAGCTGTCCCTTTCCCCCCAACACATCGCTTGACATCT
GAAGAAGTATTTGATTTGGATGGGATACCCAGGGTTGATGTTCTGAAGAACCACTTGGTG
AAAGAAGGTCGAGTAGATGAAGAAATTGCGCTTAGAATTATCAATGAGGGTGCTGCCATC
CTTCGGAGAGAGAAAACCATGATAGAAGTAGAAGCTCCAATCACAGTGTGTGGTGACATC
CATGGCCAATTTTTTGATCTGATGAAACTTTTTGAAGTAGGAGGATCACCTGCTAATACA
CGATACCTTTTTCTTGGCGATTATGTGGACAGAGGTTATTTTAGTATAGAGTGTGTCTTA
TATTTATGGGTTCTGAAGATTCTATACCCAAGCACATTATTTCTTCTGAGAGGCAACCAT
GAATGCAGACACCTTACTGAATATTTTACCTTTAAGCAGGAATGTAAAATTAAGTATTCG
GAAAGAGTCTATGAAGCTTGTATGGAAGCTTTTGATAGTTTGCCTCTTGCTGCACTTTTA
AACCAACAGTTTCTTTGTGTTCATGGTGGACTTTCACCAGAAATACACACACTGGATGAT
ATTAGGAGATTAGATAGATTCAAAGAGCCACCTGCATTTGGACCAATGTGTGACTTGTTA
TGGTCCGATCCTTCTGAAGATTTTGGAAATGAAAAATCACAGGAACATTTTAGTCACAAT
ACAGTTCGAGGATGTTCTTATTTTTATAACTATCCAGCAGTGTGTGAATTTTTGCAAAAC
AATAATTTGTTATCGATTATTAGAGCTCATGAAGCTCAAGATGCAGGCTATAGAATGTAC
AGAAAAAGTCAAACTACAGGGTTCCCTTCATTAATAACAATTTTTTCGGCACCTAATTAC
TTAGATGTCTACAATAATAAAGCTGCTGTATTAAAGTATGAAAATAATGTGATGAATATT
CGACAGTTTAACTGTTCTCCACATCCTTACTGGTTGCCTAATTTTATGGATGTCTTCACG
TGGTCTTTACCGTTTGTTGGAGAAAAAGTGACAGAAATGTTGGTAAATGTTCTGAGTATT
TGCTCTGATGATGAACTAATGACTGAAGGTGAAGACCAGTTTGATGGTTCAGCTGCAGCC
CGGAAAGAAATCATAAGAAACAAAATTCGAGCAATTGGCAAGATGGCAAGAGTCTTCTCT
GTTCTCAGGGAGGAGAGTGAAAGTGTGCTGACACTCAAGGGCCTGACTCCCACAGGGATG
TTGCCTAGTGGAGTGTTAGCTGGAGGACGGCAGACCCTGCAAAGTGCCACAGTTGAGGCT
ATTGAGGCTGAAAAAGCAATACGAGGATTCTCTCCACCACATAGAATCTGCAGTTTTGAA
GAGGCAAAGGGTTTGGATAGGATCAATGAGAGAATGCCACCTCGGAAAGATGCTGTACAG
CAAGATGGTTTCAATTCTCTGAACACCGCACATGCCACTGAGAACCACGGGACGGGCAAC
CATACTGCCCAGTGA

Protein Properties

Number of Residues

524

Molecular Weight

59122.87

Theoretical pI

5.903

Pfam Domain Function

Metallophos (PF00149 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Serine/threonine-protein phosphatase 2B catalytic subunit beta isoform
MAAPEPARAAPPPPPPPPPPPGADRVVKAVPFPPTHRLTSEEVFDLDGIPRVDVLKNHLV
KEGRVDEEIALRIINEGAAILRREKTMIEVEAPITVCGDIHGQFFDLMKLFEVGGSPANT
RYLFLGDYVDRGYFSIECVLYLWVLKILYPSTLFLLRGNHECRHLTEYFTFKQECKIKYS
ERVYEACMEAFDSLPLAALLNQQFLCVHGGLSPEIHTLDDIRRLDRFKEPPAFGPMCDLL
WSDPSEDFGNEKSQEHFSHNTVRGCSYFYNYPAVCEFLQNNNLLSIIRAHEAQDAGYRMY
RKSQTTGFPSLITIFSAPNYLDVYNNKAAVLKYENNVMNIRQFNCSPHPYWLPNFMDVFT
WSLPFVGEKVTEMLVNVLSICSDDELMTEGEDQFDGSAAARKEIIRNKIRAIGKMARVFS
VLREESESVLTLKGLTPTGMLPSGVLAGGRQTLQSATVEAIEAEKAIRGFSPPHRICSFE
EAKGLDRINERMPPRKDAVQQDGFNSLNTAHATENHGTGNHTAQ

External Links

GenBank ID Protein

Not Available

UniProtKB/Swiss-Prot ID

P16298

UniProtKB/Swiss-Prot Entry Name

PP2BB_HUMAN

PDB IDs

Not Available

GenBank Gene ID

M29551

GeneCard ID