| Identification |
|---|
| HMDB Protein ID
| CDBP03153 |
| Secondary Accession Numbers
| Not Available |
| Name
| Astrocytic phosphoprotein PEA-15 |
| Description
| Not Available |
| Synonyms
|
- 15 kDa phosphoprotein enriched in astrocytes
- PED
- Phosphoprotein enriched in diabetes
|
| Gene Name
| PEA15 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Blocks Ras-mediated inhibition of integrin activation and modulates the ERK MAP kinase cascade. Inhibits RPS6KA3 activities by retaining it in the cytoplasm. Inhibits both TNFRSF6- and TNFRSF1A-mediated CASP8 activity and apoptosis. Regulates glucose transport by controlling both the content of SLC2A1 glucose transporters on the plasma membrane and the insulin-dependent trafficking of SLC2A4 from the cell interior to the surface |
| GO Classification
|
| Function |
| binding |
| protein binding |
| Process |
| biological regulation |
| regulation of biological process |
| regulation of cell death |
| regulation of programmed cell death |
| regulation of apoptosis |
| regulation of cellular process |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1q21.1 |
| SNPs
| PEA15 |
| Gene Sequence
|
>393 bp
ATGGCTGAGTACGGGACCCTCCTGCAAGACCTGACCAACAACATCACCCTTGAAGATCTA
GAACAGCTCAAGTCGGCCTGCAAGGAAGACATCCCCAGCGAAAAGAGTGAGGAGATCACT
ACTGGCAGTGCCTGGTTTAGCTTCCTGGAGAGCCACAACAAGCTGGACAAAGACAACCTC
TCCTACATTGAGCACATCTTTGAGATCTCCCGCCGTCCTGACCTACTCACTATGGTGGTT
GACTACAGAACCCGTGTGCTGAAGATCTCTGAGGAGGATGAGCTGGACACCAAGCTAACC
CGTATCCCCAGTGCCAAGAAGTACAAAGACATTATCCGGCAGCCCTCTGAGGAAGAGATC
ATCAAATTGGCTCCCCCACCGAAGAAGGCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 130 |
| Molecular Weight
| 15039.9 |
| Theoretical pI
| 4.66 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Astrocytic phosphoprotein PEA-15
MAEYGTLLQDLTNNITLEDLEQLKSACKEDIPSEKSEEITTGSAWFSFLESHNKLDKDNL
SYIEHIFEISRRPDLLTMVVDYRTRVLKISEEDELDTKLTRIPSAKKYKDIIRQPSEEEI
IKLAPPPKKA
|
| External Links |
|---|
| GenBank ID Protein
| 5932033 |
| UniProtKB/Swiss-Prot ID
| Q15121 |
| UniProtKB/Swiss-Prot Entry Name
| PEA15_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF153274 |
| GeneCard ID
| PEA15 |
| GenAtlas ID
| PEA15 |
| HGNC ID
| HGNC:8822 |
| References |
|---|
| General References
| Not Available |