| Identification |
|---|
| HMDB Protein ID
| CDBP03112 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protocadherin beta-8 |
| Description
| Not Available |
| Synonyms
|
- PCDH-beta-8
- Protocadherin-3I
|
| Gene Name
| PCDHB8 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain |
| GO Classification
|
| Component |
| cell part |
| plasma membrane |
| membrane |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| calcium ion binding |
| Process |
| cell adhesion |
| cellular process |
| cell-cell adhesion |
| homophilic cell adhesion |
|
| Cellular Location
|
- Cell membrane
- Single-pass type I membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5q31 |
| SNPs
| PCDHB8 |
| Gene Sequence
|
>2406 bp
ATGGAGGCCAGCGGGAAGCTCATTTGCAGACAAAGGCAAGTCCTTTTTTCCTTTCTCCTT
TTGGGCTTATCTCTGGCGGGCGCGGCGGAACCTAGAAGCTATTCTGTGGTGGAGGAAACT
GAGGGCAGCTCCTTTGTCACCAATTTAGCAAAGGACCTGGGTCTGGAGCAGAGGGAATTC
TCCAGGCGGGGGGTTAGGGTTGTTTCCAGAGGGAACAAACTACATTTGCAGCTCAATCAG
GAGACCGCGGATTTGTTGCTAAATGAGAAATTGGACCGTGAGGATCTGTGCGGTCACACA
GAGCCCTGTGTGCTACGTTTCCAAGTGTTGCTAGAGAGTCCCTTCGAGTTTTTTCAAGCT
GAGCTGCAAGTAATAGACATAAACGACCACTCTCCAGTATTTCTGGACAAACAAATGTTG
GTGAAAGTATCAGAGAGCAGTCCTCCTGGGACTGCGTTTCCTCTGAAGAATGCTGAAGAC
TTAGATATAGGCCAAAACAATATTGAGAACTATATAATCAGCCCCAACTCCTATTTTCGG
GTCCTCACCCGCAAACGCAGTGATGGCAGGAAATACCCAGAGCTGGTGCTGGACAACGCG
CTGGACCGAGAGGAAGAAGCTGAGCTCAGGTTAACACTCACAGCACTGGATGGTGGCTCT
CCGCCCAGATCTGGCACTGCTCAGGTCTACATTGAAGTTGTCGATGTCAATGATAATGCC
CCTGAATTTCAGCAGCCTTTCTATAGGGTGCAGATCTCTGAGGACAGTCCAATAAGCTTC
CTGGTTGTGAAGGTCTCTGCCACGGATGTAGACACAGGAGTCAACGGAGAGATTTCCTAT
TCACTTTTCCAAGCTTCAGATGAGATAAGCAAAACTTTTAAGGTCGATTTCTTGACAGGA
GAAATTCGACTAAAGAAACAACTTGATTTCGAAAAATTTCAGTCCTATGAAGTCAATATC
GAGGCGAGAGATGCTGGAGGCTTTTCTGGAAAATGCACCGTTCTGATTCAAGTGATAGAT
GTGAACGACCATGCCCCAGAAGTTACCATGTCTGCATTTACCAGCCCAATACCTGAGAAT
GCGCCTGAAACTGTGGTTGCACTTTTCAGTGTTTCAGACCTTGATTCAGGAGAAAATGGG
AAAATAAGTTGCTCCATTCAGGAGGATCTACCCTTCCTCCTGAAATCTTCTGTGGGGAAC
TTTTACACCCTACTAACAGAGACACCACTAGACAGAGAAAGCAGAGCCGAGTACAACGTC
ACTATCACCGTCACTGACTTAGGGACACCCAGGCTGACAACACATCTCAATATGACCGTG
CTGGTGTCGGACGTCAATGACAACGCCCCCGCCTTCACCCAAACCTCCTACACCCTGTTC
GTCCGCGAGAACAACAGCCCCGCCCTGCACATCGGCAGCGTCAGCGCCACAGACAGAGAC
TCGGGCACCAACGCCCAGGTCACCTACTCGCTGCTGCCGCCCCAGGATCCGCACCTGCCC
CTCGCCTCCCTGGTCTCCATCAACACAGACAACGGCCACCTGTTCGCCCTCAGGTCGCTG
GACTACGAGGCCCTGCAGGCGTTCGAGTTCCGGGTGGGCGCTTCAGACCGCGGCTCCCCG
GCTTTGAGCAGCGAGGCGCTGGTGCGCGTGCTGGTGCTGGACGCCAACGACAACTCGCCC
TTCGTGCTGTACCCGCTGCAGAATGGCTCCGCGCCCTGCACCGAGCTGGTGCCCCGGGCG
GCCGAGCCGGGCTACCTGGTGACCAAGGTGGTGGCGGTGGACGGCGACTCGGGCCAGAAC
GCCTGGCTGTCGTACCAGCTGCTCAAGGCCACGGAGCCCGGGCTGTTCGGTGTGTGGGCG
CACAATGGCGAGGTGCGCACCGCCAGGCTGCTGAGCGAGCGCGACGCGGCCAAGCAGAGG
CTGGTGGTGCTGGTCAAGGACAATGGCGAGCCTCCGTGCTCGGCCACCGCCACGCTGCAC
TTGCTCCTGGTGGACGGCTTCTCCCAGCCCTACCTGCCGCTTCCGGAGGCTGCCCCAGCC
CAGGGCCAGGCCGACTCTCTCACCGTCTACCTGGTGGTGGCGTTGGCCTCGGTGTCTTCG
CTCTTCCTCTTCTCGGTGCTCCTGTTCGTGGCGGTGCTGCTGTGTAGGAGGAGCAGGGCG
GCCTCGGTGGGTCGCTGCTCAGTGCCTGAGGGCCCCTTTCCAGGGCATCTGGTGGACGTG
AGGGGCACCGGGAGCCTGTCTCAGAACTATCAGTACGAGGTGTGCCTGGCAGGAGGCTCA
GGGACGAATGAGTTCCAGTTCCTGAAACCAGTATTACCTAATATTCAGGGCCATTCTTTT
GGGCCAGAAATGGAACAAAACTCTAACTTTAGGAATGGCTTTGGTTTCAGCCTTCAGTTA
AAGTAA
|
| Protein Properties |
|---|
| Number of Residues
| 801 |
| Molecular Weight
| 87637.9 |
| Theoretical pI
| 4.5 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Protocadherin beta-8
MEASGKLICRQRQVLFSFLLLGLSLAGAAEPRSYSVVEETEGSSFVTNLAKDLGLEQREF
SRRGVRVVSRGNKLHLQLNQETADLLLNEKLDREDLCGHTEPCVLRFQVLLESPFEFFQA
ELQVIDINDHSPVFLDKQMLVKVSESSPPGTAFPLKNAEDLDIGQNNIENYIISPNSYFR
VLTRKRSDGRKYPELVLDKALDREEEAELRLTLTALDGGSPPRSGTAQVYIEVVDVNDNA
PEFEQPFYRVQISEDSPISFLVVKVSATDVDTGVNGEISYSLFQASDEISKTFKVDFLTG
EIRLKKQLDFEKFQSYEVNIEARDAGGFSGKCTVLIQVIDVNDHAPEVTMSAFTSPIPEN
APETVVALFSVSDLDSGENGKISCSIQEDLPFLLKSSVGNFYTLLTETPLDRESRAEYNV
TITVTDLGTPRLTTHLNMTVLVSDVNDNAPAFTQTSYTLFVRENNSPALHIGSVSATDRD
SGTNAQVTYSLLPPQDPHLPLASLVSINTDNGHLFALRSLDYEALQAFEFRVGASDRGSP
ALSSEALVRVLVLDANDNSPFVLYPLQNGSAPCTELVPRAAEPGYLVTKVVAVDGDSGQN
AWLSYQLLKATEPGLFGVWAHNGEVRTARLLSERDAAKQRLVVLVKDNGEPPCSATATLH
LLLVDGFSQPYLPLPEAAPAQGQADSLTVYLVVALASVSSLFLFSVLLFVAVLLCRRSRA
ASVGRCSVPEGPFPGHLVDVRGTGSLSQNYQYEVCLAGGSGTNEFQFLKPVLPNIQGHSF
GPEMEQNSNFRNGFGFSLQLK
|
| External Links |
|---|
| GenBank ID Protein
| 11142063 |
| UniProtKB/Swiss-Prot ID
| Q9UN66 |
| UniProtKB/Swiss-Prot Entry Name
| PCDB8_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF152501 |
| GeneCard ID
| PCDHB8 |
| GenAtlas ID
| PCDHB8 |
| HGNC ID
| HGNC:8693 |
| References |
|---|
| General References
| Not Available |