| Identification |
|---|
| HMDB Protein ID
| CDBP03103 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protocadherin alpha-12 |
| Description
| Not Available |
| Synonyms
|
- PCDH-alpha-12
|
| Gene Name
| PCDHA12 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain |
| GO Classification
|
| Component |
| membrane |
| cell part |
| plasma membrane |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| calcium ion binding |
| Process |
| cell adhesion |
| cellular process |
| cell-cell adhesion |
| homophilic cell adhesion |
|
| Cellular Location
|
- Cell membrane
- Single-pass type I membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5q31 |
| SNPs
| PCDHA12 |
| Gene Sequence
|
>2826 bp
ATGGTGATTATCGGACCAAGAGGCCCGGGATCCCAGCGTCTGCTGCTCTCGCTTCTGCTC
CTTGCAGCCTGGGAGGTGGGGAGCGGCCAGCTCCACTACTCCGTCTACGAGGAGGCCAAA
CACGGCACCTTCGTGGGCCGCATCGCTCAGGACCTGGGGCTGGAGCTGGCGGAGCTGGTG
CCGCGCCTGTTCCGGGTGGCGTCCAAAAGACACGGGGACCTTCTGGAGGTAAATCTGCAG
AATGGCATTTTGTTTGTGAATTCTCGGATCGACCGCGAGAAGCTGTGCGGGCGGAGCGCG
GAGTGCAGTATCCACCTGGAGGTGATCGTGGACAGGCCGCTGCAGGTTTTCCATGTGGAC
GTGGAGGTGAAGGACATTAACGACAACCCGCCGGTGTTCAGAGAAAGGGAACAAAAGGTA
CCTGTTTCTGAATCTGCGCCTCTGGACTCTCATTTTCCTCTAGAGGGCGCTTCTGATGCG
GATATCGGCGTAAACTCTCTTTTGACCTATGCGTTAAGTCTAAATGAGAATTTTGAGCTT
AAAATAAAAACAAAAAAAGATAAAAGTATATTGCCTGAATTAGTTCTTCGGAAGTTATTG
GACAGAGAGCAAACGCCAAAACTCAATTTATTGCTGATGGTAATCGATGGCGGTAAACCA
GAACTAACAGGGTCTGTCCAGATTCAAATAACCGTCCTGGATGTGAATGACAATGGTCCG
GCGTTTGATAAGCCCAGCTATAAAGTAGTGTTGTCTGAAAATGTCCAAAACGACACAAGA
GTGATCCAACTAAATGCTTCCGATCCAGACGAAGGACTTAATGGAGAAATTTCCTATGGG
ATCAAAATGATTTTGCCAGTGAGTGAGAAATGTATGTTTTCAATAAATCCAGACACAGGT
GAAATTAGAATTTATGGTGAACTGGATTTTGAAGAGAATAATGCCTATGAAATTCAGGTT
AACGCCATTGATAAAGGGATTCCTTCCATGGCAGGTCACAGCATGGTCCTGGTGGAAGTT
CTGGACGTGAATGACAATGTCCCTGAAGTAATGGTTACTTCACTGTCGCTCCCTGTGCAA
GAGGATGCTCAGGTGGGTACCGTCATTGCCCTGATTAGCGTGTCGGATCGTGACTCTGGA
GCCAATGGACAGGTCATCTGCTCACTGACACCTCATGTTCCCTTCAAGCTGGTGTCCACC
TACAAGAATTACTACTCGTTGGTGCTGGACAGCGCCCTGGACCGCGAGAGCGTGTCGGCC
TATGAGCTGGTGGTGACTGCGCGGGATGGGGGCTCGCCTTCGCTGTGGGCCACGGCTAGA
GTGTCCGTGGAGGTGGCCGACGTGAACGACAATGCGCCTGCGTTCGCGCAGCCCGAGTAC
ACAGTGTTCGTGAAGGAGAACAACCCGCCGGGCTGCCACATCTTCACGGTGTCGGCATGG
GACGCGGACGCGCAGAAGAACGCGCTGGTGTCCTACTCGCTGGTGGAGCGGCGGGTGGGC
GAGCACGCACTGTCGAGCTACGTGTCGGTGCACGCGGAGAGCGGCAAGGTGTACGCGCTG
CAGCCGCTAGACCACGAGGAGCTGGAGCTGCTGCAGTTCCAGGTGAGCGCGCGCGACGCC
GGCGTGCCGCCTCTGGGCAGCAACGTGACGCTGCAGGTGTTCGTGCTGGACGAGAACGAC
AACGCGCCGGCACTGCTGGCGACTCCGGCTGGCAGCGCAGGAGGCGCAGTTAGCGAGTTG
GTACCGCGGTCGGTGGGTGCGGGCCACGTGGTGGCGAAAGTGCGCGCGGTGGACGCTGAC
TCCGGCTATAACGCTTGGCTGTCCTACGAGTTGCAACCGGCGGCGGTCGGCGCGCACATC
CCGTTCCACGTGGGGCTGTACACTGGCGAGATCAGCACGACACGCATCCTGGATGAGGCG
GACGCTCCGCGCCACCGCCTGCTGGTGCTGGTGAAGGACCACGGTGAGCCCGCGCTGACG
TCCACGGCCACGGTGCTGGTGTCGCTGGTGGAGAACGGCCAGGCCCCAAAGACGTCGTCG
CGGGCCTCAGTGGGCGCTGTGGATCCCGAAGCGGCTCTGGTGGATATTAACGTGTACCTC
ATCATCGCCATCTGTGCGGTGTCCAGCCTGCTGGTGCTCACGCTGCTGCTGTACACTGCG
CTGCGTTGCTCAGCGCCGCCCACCGTGAGCCGGTGCGCGCCGGGCAAGCCCACGCTGGTG
TGCTCCAGCGCCGTGGGGAGTTGGTCTTACTCGCAGCAGAGGAGGCAGAGGGTGTGCTCT
GCAGAGAGCCCGCCCAAGACGGACCTCATGGCCTTCAGCCCAAGCCTTCAGCTGTCTCGA
GAAGATTGTTTAAATCCTCCCAGTGAACCACGACAGCCCAACCCTGACTGGCGTTACTCT
GCCTCCCTGAGAGCAGGCATGCACAGCTCTGTGCACCTAGAGGAGGCTGGCATTCTACGG
GCTGGTCCAGGAGGGCCTGATCAGCAGTGGCCAACAGTATCCAGTGCAACACCAGAACCA
GAGGCAGGAGAAGTGTCCCCTCCAGTCGGTGCGGGTGTCAACAGCAACAGCTGGACCTTT
AAATACGGACCAGGCAACCCCAAACAATCCGGTCCCGGTGAGTTGCCCGACAAATTCATT
ATCCCAGGATCTCCTGCAATCATCTCCATCCGGCAGGAGCCTACTAACAGCCAAATTGAC
AAAAGTGACTTCATAACCTTCGGCAAAAAGGAGGAGACCAAGAAAAAGAAGAAAAAGAAG
AAGGGTAACAAGACCCAGGAGAAAAAAGAGAAAGGGAACAGCACGACTGACAACAGTGAC
CAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 941 |
| Molecular Weight
| 101651.1 |
| Theoretical pI
| 4.91 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Protocadherin alpha-12
MVIIGPRGPGSQRLLLSLLLLAAWEVGSGQLHYSVYEEAKHGTFVGRIAQDLGLELAELV
PRLFRVASKRHGDLLEVNLQNGILFVNSRIDREKLCGRSAECSIHLEVIVDRPLQVFHVD
VEVKDINDNPPVFREREQKVPVSESAPLDSHFPLEGASDADIGVNSLLTYALSLNENFEL
KIKTKKDKSILPELVLRKLLDREQTPKLNLLLMVIDGGKPELTGSVQIQITVLDVNDNGP
AFDKPSYKVVLSENVQNDTRVIQLNASDPDEGLNGEISYGIKMILPVSEKCMFSINPDTG
EIRIYGELDFEENNAYEIQVNAIDKGIPSMAGHSMVLVEVLDVNDNVPEVMVTSLSLPVQ
EDAQVGTVIALISVSDRDSGANGQVICSLTPHVPFKLVSTYKNYYSLVLDSALDRESVSA
YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAW
DADAQKNALVSYSLVERRVGEHALSSYVSVHAESGKVYALQPLDHEELELLQFQVSARDA
GVPPLGSNVTLQVFVLDENDNAPALLATPAGSAGGAVSELVPRSVGAGHVVAKVRAVDAD
SGYNAWLSYELQPAAVGAHIPFHVGLYTGEISTTRILDEADAPRHRLLVLVKDHGEPALT
STATVLVSLVENGQAPKTSSRASVGAVDPEAALVDINVYLIIAICAVSSLLVLTLLLYTA
LRCSAPPTVSRCAPGKPTLVCSSAVGSWSYSQQRRQRVCSAESPPKTDLMAFSPSLQLSR
EDCLNPPSEPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVSSATPEP
EAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEPTNSQID
KSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
|
| External Links |
|---|
| GenBank ID Protein
| 9256578 |
| UniProtKB/Swiss-Prot ID
| Q9UN75 |
| UniProtKB/Swiss-Prot Entry Name
| PCDAC_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_018903.2 |
| GeneCard ID
| PCDHA12 |
| GenAtlas ID
| PCDHA12 |
| HGNC ID
| HGNC:8666 |
| References |
|---|
| General References
| Not Available |