| Identification |
|---|
| HMDB Protein ID
| CDBP03095 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protocadherin alpha-4 |
| Description
| Not Available |
| Synonyms
|
- PCDH-alpha-4
|
| Gene Name
| PCDHA4 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain |
| GO Classification
|
| Component |
| membrane |
| cell part |
| plasma membrane |
| Function |
| metal ion binding |
| binding |
| calcium ion binding |
| ion binding |
| cation binding |
| Process |
| cell adhesion |
| cellular process |
| cell-cell adhesion |
| homophilic cell adhesion |
|
| Cellular Location
|
- Cell membrane
- Single-pass type I membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5q31 |
| SNPs
| PCDHA4 |
| Gene Sequence
|
>2844 bp
ATGGAGTTTTCCTGGGGAAGCGGCCAGGAATCCCGGCGTCTGCTGCTCTTACTTCTTCTC
CTCGCAGCCTGGGAGGCAGGGAACGGTCAGCTCCACTACTCGGTCTCCGAGGAGGCCAAA
CACGGCACCTTCGTGGGCCGCATCGCGCAGGACCTGGGACTGGAGCTGGCGGAGCTGGTG
CCGCGCCTGTTCCGGGTGGCGTCCAAGGGCCGCGGAGGCCTTCTGGAGGTAAATCTGCAG
AATGGCATTTTGTTTGTGAATTCTCGGATCGACCGGGAGGAGCTGTGCCGGCGGAGCGCG
GAGTGCAGCATCCACCTGGAGGTGATCGTAGACAGGCCGCTGCAGGTTTTCCATGTGGAC
GTGGAGGTGAGGGACATTAACGATAACCCGCCGGTGTTCCCAGCAACACAAAAGAACCTG
TCCATCGCGGAATCCAGGCCGCTTGACTCTCGGTTTCCACTAGAGGGCGCCTCGGATGCA
GATATCGGGGAGAACGCCCTGCTCACTTACAGACTGAGCCCAAATGAATACTTTTCTCTG
GAAAAACCACCTGATGACGAGCTGGTAAAAGGTCTTGGGCTTATATTACGGAAATCTTTA
GACAGAGAAGAAGCTCCGGAGATTTTTTTAGTGCTCACAGCCACTGATGGAGGCAAACCC
GAGTTGACTGGCACCGTTCAGTTACTCATCACAGTACTGGATGCCAATGACAATGCCCCA
GCTTTTGACAGAACCATTTATAAGGTGAGATTACTAGAAAATGTTCCTAATGGAACATTG
GTAATTAAACTTAACGCCTCAGATTTAGACGAAGGATTGAATGGGGACATTGTTTATTCA
TTCTCAAATGATATTTCGCCAAATGTGAAATCCAAGTTTCACATAGATCCAATTACTGGA
CAAATTATTGTAAAGGGATATATTGACTTTGAAGAAAGCAAATCCTATGAAATTATTGTA
GAGGGCATTGATAAGGGACAGCTCCCACTTTCTGGCCATTGTAGAGTTATTGTGGAAGTA
GAAGACAACAACGATAATGTCCCAGATTTGGAATTCAAGTCTTTATCACTTCCAATTAGA
GAGGACGCTCCACTGGGTACAGTCATCGCCCTGATCAGCGTGTCCGACAAAGACATGGGT
GTCAATGGGCTGGTCACCTGCTCCTTGACGTCCCACGTCCCCTTCAAGCTGGTGTCCACC
TTCAAGAATTACTACTCGTTGGTGCTGGACAGTGCCCTGGACCGCGAGAGCGTGTCAGCC
TATGAGCTGGTGGTGACCGCGCGAGACGGGGGCTCGCCTTCGCTGTGGGCCACGGCCAGT
GTTTCTGTGGAGGTGGCTGATGTGAACGACAACGCTCCGGCGTTCGCGCAGCCCGAGTAC
ACAGTGTTCGTGAAGGAGAACAACCCGCCGGGCTGCCACATCTTCACTGTGTCTGCGTGG
GACGCGGACGCGCAGGAGAACGCGCTGGTGTCCTACTCGCTGGTAGAGCGGCGGGTAGGG
GAGCGCGCGCTGTCGAGCTACGTTTCGGTGCATGCGGAGAGCGGCAAGGTGTACGCGCTG
CAGCCGCTGGACCACGAGGAGCTAGAGCTGCTGCAGTTTCAGGTGACCGCTCGCGATGCC
GGCGTGCCACCTCTGGGCAGCAACGTGACGCTGCAGGTGTTCGTGCTGGACGAAAACGAC
AACGCGCCAGCACTGCTAGCGCCTCGGGCGGGTGGCACTGGTGGCGCAGTGAGCGAGCTG
GTGCCATGGTCGGTGGGTGTGGGCCACGTGGTGGCAAAGGTGCGCGCGGTGGATGCTGAC
TCGGGCTACAACGCGTGGCTTTCGTACGAGCTGCAGCCGGGGACTGGTGGCGCGCGCATC
CCGTTCCGCGTGGGGCTGTACACTGGCGAGATCAGCACAACGCGTGCCCTGGACGAAACG
GACGCTCCGCGCCACCGCCTACTGGTACTGGTGAAGGACCACGGCGAGCCCGCGCTGACG
GCCACGGCCACTGTGCTGGTGTCACTTGTGGAGAGTGGACAGGCGCCAAAGGCCTCCTCA
CGGGCGTTGGTGGGCGCTGTGGGTCCCGATGCTGCGCTGGTGGATGTCAACGTATACCTG
ATCATTGCCATCTGCGCGGTGTCCAGCCTTTTGGTGCTCACGCTGCTGCTGTACACCGCG
CTGCGGTGCTCTGCGCTGCCCACCGAGGGCGCGTGCGCTCCGGGCAAGCCCACGCTGGTG
TGCTCCAGTGCGGTGGGGAGCTGGTCATACTCGCAGCAGAGGAGGCCGAGGGTGTGCTCT
GGTGAGGGCCCACCCAAGACCGACCTCATGGCCTTCAGCCCCAGTTTACCTGACTCTAGG
GACAGAGAAGATCAGCTGCAGACAACTGAGGAATCCTTTGCAAAGCCACGACAGCCCAAC
CCTGACTGGCGTTACTCTGCCTCCCTGAGAGCAGGCATGCACAGCTCTGTGCACCTAGAG
GAGGCTGGCATTCTACGGGCTGGTCCAGGAGGGCCTGATCAGCAGTGGCCAACAGTATCC
AGTGCAACACCAGAACCAGAGGCAGGAGAAGTGTCCCCTCCAGTCGGTGCGGGTGTCAAC
AGCAACAGCTGGACCTTTAAATACGGACCAGGCAACCCCAAACAATCCGGTCCCGGTGAG
TTGCCCGACAAATTCATTATCCCAGGATCTCCTGCAATCATCTCCATCCGGCAGGAGCCT
ACTAACAGCCAAATTGACAAAAGTGACTTCATAACCTTCGGCAAAAAGGAGGAGACCAAG
AAAAAGAAGAAAAAGAAGAAGGGTAACAAGACCCAGGAGAAAAAAGAGAAAGGGAACAGC
ACGACTGACAACAGTGACCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 947 |
| Molecular Weight
| 102292.3 |
| Theoretical pI
| 4.71 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Protocadherin alpha-4
MEFSWGSGQESRRLLLLLLLLAAWEAGNGQLHYSVSEEAKHGTFVGRIAQDLGLELAELV
PRLFRVASKGRGGLLEVNLQNGILFVNSRIDREELCRRSAECSIHLEVIVDRPLQVFHVD
VEVRDINDNPPVFPATQKNLSIAESRPLDSRFPLEGASDADIGENALLTYRLSPNEYFSL
EKPPDDELVKGLGLILRKSLDREEAPEIFLVLTATDGGKPELTGTVQLLITVLDANDNAP
AFDRTIYKVRLLENVPNGTLVIKLNASDLDEGLNGDIVYSFSNDISPNVKSKFHIDPITG
QIIVKGYIDFEESKSYEIIVEGIDKGQLPLSGHCRVIVEVEDNNDNVPDLEFKSLSLPIR
EDAPLGTVIALISVSDKDMGVNGLVTCSLTSHVPFKLVSTFKNYYSLVLDSALDRESVSA
YELVVTARDGGSPSLWATASVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAW
DADAQENALVSYSLVERRVGERALSSYVSVHAESGKVYALQPLDHEELELLQFQVTARDA
GVPPLGSNVTLQVFVLDENDNAPALLAPRAGGTGGAVSELVPWSVGVGHVVAKVRAVDAD
SGYNAWLSYELQPGTGGARIPFRVGLYTGEISTTRALDETDAPRHRLLVLVKDHGEPALT
ATATVLVSLVESGQAPKASSRALVGAVGPDAALVDVNVYLIIAICAVSSLLVLTLLLYTA
LRCSALPTEGACAPGKPTLVCSSAVGSWSYSQQRRPRVCSGEGPPKTDLMAFSPSLPDSR
DREDQLQTTEESFAKPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWPTVS
SATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIRQEP
TNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
|
| External Links |
|---|
| GenBank ID Protein
| 9256588 |
| UniProtKB/Swiss-Prot ID
| Q9UN74 |
| UniProtKB/Swiss-Prot Entry Name
| PCDA4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_018907.2 |
| GeneCard ID
| PCDHA4 |
| GenAtlas ID
| PCDHA4 |
| HGNC ID
| HGNC:8670 |
| References |
|---|
| General References
| Not Available |