| Identification |
|---|
| HMDB Protein ID
| CDBP03092 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protocadherin alpha-1 |
| Description
| Not Available |
| Synonyms
|
- PCDH-alpha-1
|
| Gene Name
| PCDHA1 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain |
| GO Classification
|
| Component |
| plasma membrane |
| membrane |
| cell part |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| calcium ion binding |
| Process |
| cell adhesion |
| cellular process |
| cell-cell adhesion |
| homophilic cell adhesion |
|
| Cellular Location
|
- Isoform 2:Secreted (Potential)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5q31 |
| SNPs
| PCDHA1 |
| Gene Sequence
|
>2853 bp
ATGGTGTTTTCTAGGAGAGGGGGCCTGGGAGCCCGGGATCTGCTTCTTTGGCTTCTGCTC
CTCGCAGCCTGGGAGGTGGGGAGCGGCCAGCTCCACTACTCGATCCCGGAGGAAGCCAAA
CACGGCACCTTCGTTGGCCGCGTTGCTCAGGACCTGGGACTGGAGCTGGCGGAGCTGGTG
CCTCGCCTGTTCCGGGTGGCGTCCAAAACACACAGGGACCTTCTGGAGGTAAATCTGCAG
AATGGCATTTTGTTTGTGAATTCTCGGATCGATCGCGAGGAGCTGTGCCAGTGGAGCGCG
GAGTGCAGCATCCACCTGGAGTTGATCGCCGACAGGCCGCTGCAGGTTTTCCATGTGGAG
GTGAAGGTGAAAGACATTAACGATAATCCACCCGTCTTCAGGGGCAGAGAACAAATAATA
TTTATTCCTGAATCTAGACTCCTGAATTCGCGTTTTCCGATAGAAGGAGCTGCTGATGCA
GACATTGGTGCTAACGCTCTTCTAACGTACACGCTCAGCCCGAGTGATTATTTCTCTTTG
GATGTAGAGGCAAGTGATGAACTGAGTAAATCTCTTTGGCTTGAATTGAGAAAATATTTG
GATAGAGAAGAAACACCAGAACTTCACTTATTACTGACTGCCACTGATGGGGGCAAACCG
GAGCTGCAAGGTACAGTTGAGCTGCTGATCACCGTCCTCGACGTTAATGATAACGCCCCA
CTGTTTGACCAGGCCGTATACAGAGTCCACTTGTTAGAGACTACAGCAAATGGAACATTA
GTGACCACATTAAATGCCTCTGATGCTGACGAAGGTGTAAATGGTGAAGTCGTCTTTTCC
TTTGACAGTGGTATTTCTCGTGACATTCAAGAAAAATTCAAAGTTGATTCCAGCTCAGGA
GAAATTAGGTTAATTGATAAACTGGATTATGAAGAAACAAAATCCTACGAAATTCAAGTA
AAGGCAGTTGATAAAGGAAGTCCTCCGATGTCAAATCACTGTAAGGTTTTGGTGAAAGTG
CTGGATGTAAATGATAATGCTCCAGAACTGGCGGTCACTTCATTGTATTTGCCTATCAGA
GAGGACGCTCCACTCAGCACCGTCATCGCCCTCATCACCGTGTCTGACCGTGACTCAGGT
GCCAACGGGCAGGTGACTTGCTCCTTAATGCCCCACGTCCCCTTCAAGCTGGTGTCCACC
TTCAAGAATTACTACTCGTTGGTGTTGGACAGCGCCCTGGATCGCGAGAGCCTGTCGGTC
TATGAGCTGGTGGTGACCGCGCGGGACGGGGGCTCGCCTTCGCTGTGGGCCACGGCCAGG
GTGTCCGTGGAGGTGGCCGACGTGAATGACAACGCGCCTGCGTTCGCGCAGCCCGAGTAC
ACAGTATTCGTGAAGGAGAACAACCCGCCGGGCTGCCACATCTTCACGGTGTCTGCGCGG
GACGCGGACGCGCAGGAGAACGCGCTGGTGTCCTATTCGCTGGTGGAACGGCGGGTGGGC
GAGCGCGCGCTGTCGAACTACGTGTCAGTGCACGCGGAGAGCGGCAAGGTGTACGCACTG
CAGCCCCTGGACCACGAGGAGCTGGAGCTGCTGCAGTTCCAGGTGAGCGCGCGGGATGCG
GGCGTGCCGCCTCTGGGCAGCAACGTGACGCTGCAGGTGTTCGTGCTGGACGAGAACGAC
AACGCGCCGGCGCTGCTGGCGCCTCGAGTGGGTGGCACTATTGGTGCAGTCAGTGAGCTG
GTGCCGCGATTGGTGGGTGCGGGTCATGTGGTGGCGAAGGTGCGCGCAGTGGACGCCGAC
TCGGGCTACAACGCGTGGCTGTCCTATGAACTGCAGCCGGCAGCAGGCGGCGCGCGCATC
CCGTTCCGCGTGGGGCTGTACACGGGCGAGATCAGCACGACTCGTGTCCTGGACGAGGCT
GACTTGTCGCGCTACCGCCTTCTGGTGCTAGTGAAGGATCACGGTGAGCCGGCGCTGACA
GCCACGGCCACTGTGCTTGTATCTCTGGTGGAGAGCGGCCAGGCGCCAAAGGCGTCTTCG
CGGGCGTCGGTGGGTGTCGCGGGCCCAGAGGCGGCGCTGGTGGATGTCAACGTGTACCTG
ATCATCGCCATCTGCGCGGTGTCCAGCCTGCTGGTGCTCACACTGCTGCTGTACACGGCG
CTGCGGTGCTCAGTGCCGCCCACTGAGGGTGCGTATGTGCCGGGCAAGCCCACTCTGGTG
TGCTCCAGCGCGTTGGGGAGCTGGTCGAACTCACAGCAGAGGCGGCAGAGGGTGTGCTCT
AGCGAGGGCCCACCCAAGACCGACCTCATGGCCTTCAGCCCAGGCCTATCTCCAAGTCTT
AACACGTCAGAAAGAAATGAACAACCAGAAGCAAATTTGGATCTTTCTGGTAATCCACGA
CAGCCCAACCCTGACTGGCGTTACTCTGCCTCCCTGAGAGCAGGCATGCACAGCTCTGTG
CACCTAGAGGAGGCTGGCATTCTACGGGCTGGTCCAGGAGGGCCTGATCAGCAGTGGCCA
ACAGTATCCAGTGCAACACCAGAACCAGAGGCAGGAGAAGTGTCCCCTCCAGTCGGTGCG
GGTGTCAACAGCAACAGCTGGACCTTTAAATACGGACCAGGCAACCCCAAACAATCCGGT
CCCGGTGAGTTGCCCGACAAATTCATTATCCCAGGATCTCCTGCAATCATCTCCATCCGG
CAGGAGCCTACTAACAGCCAAATTGACAAAAGTGACTTCATAACCTTCGGCAAAAAGGAG
GAGACCAAGAAAAAGAAGAAAAAGAAGAAGGGTAACAAGACCCAGGAGAAAAAAGAGAAA
GGGAACAGCACGACTGACAACAGTGACCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 950 |
| Molecular Weight
| 102951.1 |
| Theoretical pI
| 4.78 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Protocadherin alpha-1
MVFSRRGGLGARDLLLWLLLLAAWEVGSGQLHYSIPEEAKHGTFVGRVAQDLGLELAELV
PRLFRVASKTHRDLLEVNLQNGILFVNSRIDREELCQWSAECSIHLELIADRPLQVFHVE
VKVKDINDNPPVFRGREQIIFIPESRLLNSRFPIEGAADADIGANALLTYTLSPSDYFSL
DVEASDELSKSLWLELRKYLDREETPELHLLLTATDGGKPELQGTVELLITVLDVNDNAP
LFDQAVYRVHLLETTANGTLVTTLNASDADEGVNGEVVFSFDSGISRDIQEKFKVDSSSG
EIRLIDKLDYEETKSYEIQVKAVDKGSPPMSNHCKVLVKVLDVNDNAPELAVTSLYLPIR
EDAPLSTVIALITVSDRDSGANGQVTCSLMPHVPFKLVSTFKNYYSLVLDSALDRESLSV
YELVVTARDGGSPSLWATARVSVEVADVNDNAPAFAQPEYTVFVKENNPPGCHIFTVSAR
DADAQENALVSYSLVERRVGERALSNYVSVHAESGKVYALQPLDHEELELLQFQVSARDA
GVPPLGSNVTLQVFVLDENDNAPALLAPRVGGTIGAVSELVPRLVGAGHVVAKVRAVDAD
SGYNAWLSYELQPAAGGARIPFRVGLYTGEISTTRVLDEADLSRYRLLVLVKDHGEPALT
ATATVLVSLVESGQAPKASSRASVGVAGPEAALVDVNVYLIIAICAVSSLLVLTLLLYTA
LRCSVPPTEGAYVPGKPTLVCSSALGSWSNSQQRRQRVCSSEGPPKTDLMAFSPGLSPSL
NTSERNEQPEANLDLSGNPRQPNPDWRYSASLRAGMHSSVHLEEAGILRAGPGGPDQQWP
TVSSATPEPEAGEVSPPVGAGVNSNSWTFKYGPGNPKQSGPGELPDKFIIPGSPAIISIR
QEPTNSQIDKSDFITFGKKEETKKKKKKKKGNKTQEKKEKGNSTTDNSDQ
|
| External Links |
|---|
| GenBank ID Protein
| 9256582 |
| UniProtKB/Swiss-Prot ID
| Q9Y5I3 |
| UniProtKB/Swiss-Prot Entry Name
| PCDA1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_018900.2 |
| GeneCard ID
| PCDHA1 |
| GenAtlas ID
| PCDHA1 |
| HGNC ID
| HGNC:8663 |
| References |
|---|
| General References
| Not Available |