| Identification |
|---|
| HMDB Protein ID
| CDBP03083 |
| Secondary Accession Numbers
| Not Available |
| Name
| Protocadherin-12 |
| Description
| Not Available |
| Synonyms
|
- VE-cad-2
- VE-cadherin-2
- Vascular cadherin-2
- Vascular endothelial cadherin-2
|
| Gene Name
| PCDH12 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Cellular adhesion molecule that may play an important role in cell-cell interactions at interendothelial junctions. Promotes homotypic calcium dependent aggregation and adhesion and clusters at intercellular junctions. Unable to bind to catenins, weakly associates with the cytoskeleton |
| GO Classification
|
| Component |
| membrane |
| cell part |
| plasma membrane |
| Function |
| calcium ion binding |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| Process |
| cell adhesion |
| cellular process |
| cell-cell adhesion |
| homophilic cell adhesion |
|
| Cellular Location
|
- Cell membrane
- Single-pass type I membrane protein
- Cell junction
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5q31 |
| SNPs
| PCDH12 |
| Gene Sequence
|
>3555 bp
ATGATGCAACTTCTGCAACTTCTGCTGGGGCTTTTGGGGCCAGGTGGCTACTTATTTCTT
TTAGGGGATTGTCAGGAGGTGACCACTCTCACGGTGAAATACCAAGTGTCAGAGGAAGTG
CCATCTGGTACAGTGATCGGGAAGCTGTCCCAGGAACTGGGCCGGGAGGAGAGGCGGAGG
CAAGCTGGGGCTGCCTTCCAGGTGTTGCAGCTGCCTCAGGCGCTCCCCATTCAGGTGGAC
TCTGAGGAAGGCTTGCTCAGCACAGGCAGGCGGCTGGATCGAGAGCAGCTGTGCCGACAG
TGGGATCCCTGCCTGGTTTCCTTTGATGTGCTTGCCACAGGGGATTTGGCTCTGATCCAT
GTGGAGATCCAAGTGCTGGACATCAATGACCACCAGCCACGGTTTCCCAAAGGCGAGCAG
GAGCTGGAAATCTCTGAGAGCGCCTCTCTGCGAACCCGGATCCCCCTGGACAGAGCTCTT
GACCCAGACACAGGCCCTAACACCCTGCACACCTACACTCTGTCTCCCAGTGAGCACTTT
GCCTTGGATGTCATTGTGGGCCCTGATGAGACCAAACATGCAGAACTCATAGTGGTGAAG
GAGCTGGACAGGGAAATCCATTCATTTTTTGATCTGGTGTTAACTGCCTATGACAATGGG
AACCCCCCCAAGTCAGGTACCAGCTTGGTCAAGGTCAACGTCTTGGACTCCAATGACAAT
AGCCCTGCGTTTGCTGAGAGTTCACTGGCACTGGAAATCCAAGAAGATGCTGCACCTGGT
ACGCTTCTCATAAAACTGACCGCCACAGACCCTGACCAAGGCCCCAATGGGGAGGTGGAG
TTCTTCCTCAGTAAGCACATGCCTCCAGAGGTGCTGGACACCTTCAGTATTGATGCCAAG
ACAGGCCAGGTCATTCTGCGTCGACCTCTAGACTATGAAAAGAACCCTGCCTACGAGGTG
GATGTTCAGGCAAGGGACCTGGGTCCCAATCCTATCCCAGCCCATTGCAAAGTTCTCATC
AAGGTTCTGGATGTCAATGACAACATCCCAAGCATCCACGTCACATGGGCCTCCCAGCCA
TCACTGGTGTCAGAAGCTCTTCCCAAGGACAGTTTTATTGCTCTTGTCATGGCAGATGAC
TTGGATTCAGGACACAATGGTTTGGTCCACTGCTGGCTGAGCCAAGAGCTGGGCCACTTC
AGGCTGAAAAGAACTAATGGCAACACATACATGTTGCTAACCAATGCCACACTGGACAGA
GAGCAGTGGCCCAAATATACCCTCACTCTGTTAGCCCAAGACCAAGGACTCCAGCCCTTA
TCAGCCAAGAAACAGCTCAGCATTCAGATCAGTGACATCAACGACAATGCACCTGTGTTT
GAGAAAAGCAGGTATGAAGTCTCCACGCGGGAAAACAACTTACCCTCTCTTCACCTCATT
ACCATCAAGGCTCATGATGCAGACTTGGGCATTAATGGAAAAGTCTCATACCGCATCCAG
GACTCCCCAGTTGCTCACTTAGTAGCTATTGACTCCAACACAGGAGAGGTCACTGCTCAG
AGGTCACTGAACTATGAAGAGATGGCCGGCTTTGAGTTCCAGGTGATCGCAGAGGACAGC
GGGCAACCCATGCTTGCATCCAGTGTCTCTGTGTGGGTCAGCCTCTTGGATGCCAATGAT
AATGCCCCAGAGGTGGTCCAGCCTGTGCTCAGCGATGGAAAAGCCAGCCTCTCCGTGCTT
GTGAATGCCTCCACAGGCCACCTGCTGGTGCCCATCGAGACTCCCAATGGCTTGGGCCCA
GCGGGCACTGACACACCTCCACTGGCCACTCACAGCTCCCGGCCATTCCTTTTGACAACC
ATTGTGGCAAGAGATGCAGACTCGGGGGCAAATGGAGAGCCCCTCTACAGCATCCGCAGT
GGAAATGAAGCCCACCTCTTCATCCTCAACCCTCATACGGGGCAGCTGTTCGTCAATGTC
ACCAATGCCAGCAGCCTCATTGGGAGTGAGTGGGAGCTGGAGATAGTAGTAGAGGACCAG
GGAAGCCCCCCCTTACAGACCCGAGCCCTGTTGAGGGTCATGTTTGTCACCAGTGTGGAC
CACCTGAGGGACTCAGCCCGCAAGCCTGGGGCCTTGAGCATGTCGATGCTGACGGTGATC
TGCCTGGCTGTACTGTTGGGCATCTTCGGGTTGATCCTGGCTTTGTTCATGTCCATCTGC
CGGACAGAAAAGAAGGACAACAGGGCCTACAACTGTCGGGAGGCCGAGTCCACCTACCGC
CAGCAGCCCAAGAGGCCCCAGAAACACATTCAGAAGGCAGACATCCACCTCGTGCCTGTG
CTCAGGGGTCAGGCAGGTGAGCCTTGTGAAGTCGGGCAGTCCCACAAAGATGTGGACAAG
GAGGCGATGATGGAAGCAGGCTGGGACCCCTGCCTGCAGGCCCCCTTCCACCTCACCCCG
ACCCTGTACAGGACGCTGCGTAATCAAGGCAACCAGGGAGCACCGGCGGAGAGCCGAGAG
GTGCTGCAAGACACGGTCAACCTCCTTTTCAACCATCCCAGGCAGAGGAATGCCTCCCGG
GAGAACCTGAACCTTCCCGAGCCCCAGCCTGCCACAGGCCAGCCACGTTCCAGGCCTCTG
AAGGTTGCAGGCAGCCCCACAGGGAGGCTGGCTGGAGACCAGGGCAGTGAGGAAGCCCCA
CAGAGGCCACCAGCCTCCTCTGCAACCCTGAGACGGCAGCGACATCTCAATGGCAAAGTG
TCCCCTGAGAAAGAATCAGGGCCCCGTCAGATCCTGCGGAGCCTGGTCCGGCTGTCTGTG
GCTGCCTTCGCCGAGCGGAACCCCGTGGAGGAGCTCACTGTGGATTCTCCTCCTGTTCAG
CAAATCTCCCAGCTGCTGTCCTTGCTGCATCAGGGCCAATTCCAGCCCAAACCAAACCAC
CGAGGAAATAAGTACTTGGCCAAGCCAGGAGGCAGCAGGAGTGCAATCCCAGACACAGAT
GGCCCAAGTGCAAGGGCTGGAGGCCAGACAGACCCAGAACAGGAGGAAGGGCCTTTGGAT
CCTGAAGAGGACCTCTCTGTGAAGCAACTGCTAGAAGAAGAGCTGTCAAGTCTGCTGGAC
CCCAGCACAGGTCTGGCCCTGGACCGGCTGAGCGCCCCTGACCCGGCCTGGATGGCGAGA
CTCTCTTTGCCCCTCACCACCAACTACCGTGACAATGTGATCTCCCCGGATGCTGCAGCC
ACGGAGGAGCCAAGGACCTTCCAGACGTTCGGCAAGGCAGAGGCACCAGAGCTGAGCCCA
ACAGGCACGAGGCTGGCCAGCACCTTTGTCTCGGAGATGAGCTCACTGCTGGAGATGCTG
CTGGAACAGCGCTCCAGCATGCCCGTGGAGGCCGCCTCCGAGGCGCTGCGGCGGCTCTCG
GTCTGCGGGAGGACCCTCAGTTTAGACTTGGCCACCAGTGCAGCCTCAGGCATGAAAGTG
CAAGGGGACCCAGGTGGAAAGACGGGGACTGAGGGCAAGAGCAGAGGCAGCAGCAGCAGC
AGCAGGTGCCTGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1184 |
| Molecular Weight
| 128993.3 |
| Theoretical pI
| 4.93 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Protocadherin-12
MMQLLQLLLGLLGPGGYLFLLGDCQEVTTLTVKYQVSEEVPSGTVIGKLSQELGREERRR
QAGAAFQVLQLPQALPIQVDSEEGLLSTGRRLDREQLCRQWDPCLVSFDVLATGDLALIH
VEIQVLDINDHQPRFPKGEQELEISESASLRTRIPLDRALDPDTGPNTLHTYTLSPSEHF
ALDVIVGPDETKHAELIVVKELDREIHSFFDLVLTAYDNGNPPKSGTSLVKVNVLDSNDN
SPAFAESSLALEIQEDAAPGTLLIKLTATDPDQGPNGEVEFFLSKHMPPEVLDTFSIDAK
TGQVILRRPLDYEKNPAYEVDVQARDLGPNPIPAHCKVLIKVLDVNDNIPSIHVTWASQP
SLVSEALPKDSFIALVMADDLDSGHNGLVHCWLSQELGHFRLKRTNGNTYMLLTNATLDR
EQWPKYTLTLLAQDQGLQPLSAKKQLSIQISDINDNAPVFEKSRYEVSTRENNLPSLHLI
TIKAHDADLGINGKVSYRIQDSPVAHLVAIDSNTGEVTAQRSLNYEEMAGFEFQVIAEDS
GQPMLASSVSVWVSLLDANDNAPEVVQPVLSDGKASLSVLVNASTGHLLVPIETPNGLGP
AGTDTPPLATHSSRPFLLTTIVARDADSGANGEPLYSIRSGNEAHLFILNPHTGQLFVNV
TNASSLIGSEWELEIVVEDQGSPPLQTRALLRVMFVTSVDHLRDSARKPGALSMSMLTVI
CLAVLLGIFGLILALFMSICRTEKKDNRAYNCREAESTYRQQPKRPQKHIQKADIHLVPV
LRGQAGEPCEVGQSHKDVDKEAMMEAGWDPCLQAPFHLTPTLYRTLRNQGNQGAPAESRE
VLQDTVNLLFNHPRQRNASRENLNLPEPQPATGQPRSRPLKVAGSPTGRLAGDQGSEEAP
QRPPASSATLRRQRHLNGKVSPEKESGPRQILRSLVRLSVAAFAERNPVEELTVDSPPVQ
QISQLLSLLHQGQFQPKPNHRGNKYLAKPGGSRSAIPDTDGPSARAGGQTDPEQEEGPLD
PEEDLSVKQLLEEELSSLLDPSTGLALDRLSAPDPAWMARLSLPLTTNYRDNVISPDAAA
TEEPRTFQTFGKAEAPELSPTGTRLASTFVSEMSSLLEMLLEQRSSMPVEAASEALRRLS
VCGRTLSLDLATSAASGMKVQGDPGGKTGTEGKSRGSSSSSRCL
|
| External Links |
|---|
| GenBank ID Protein
| 7678873 |
| UniProtKB/Swiss-Prot ID
| Q9NPG4 |
| UniProtKB/Swiss-Prot Entry Name
| PCD12_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB026893 |
| GeneCard ID
| PCDH12 |
| GenAtlas ID
| PCDH12 |
| HGNC ID
| HGNC:8657 |
| References |
|---|
| General References
| Not Available |