Cannabis Compound Database: Showing Protein Cytosolic phospholipase A2 zeta (CDBP03079)

Identification Biological properties Gene properties Protein properties External links References XML Show 23 compounds

Identification

HMDB Protein ID

CDBP03079

Secondary Accession Numbers

Not Available

Name

Cytosolic phospholipase A2 zeta

Description

Not Available

Synonyms

Phospholipase A2 group IVF
cPLA2-zeta

Gene Name

PLA2G4F

Protein Type

Enzyme

Biological Properties

General Function

Involved in metabolic process

Specific Function

Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Has higher enzyme activity for phosphatidylethanolamine than phosphatidylcholine (By similarity).

GO Classification

Biological Process
phospholipid catabolic process
arachidonic acid secretion
cellular response to organic cyclic compound
glycerophospholipid biosynthetic process
phosphatidylglycerol acyl-chain remodeling
prostaglandin biosynthetic process
phosphatidylcholine acyl-chain remodeling
phosphatidylethanolamine acyl-chain remodeling
phosphatidylinositol acyl-chain remodeling
phosphatidylserine acyl-chain remodeling
cellular response to antibiotic
Cellular Component
cytosol
vesicle
ruffle membrane
lysosomal membrane
Function
hydrolase activity, acting on ester bonds
catalytic activity
hydrolase activity
lipase activity
phospholipase activity
Molecular Function
lysophospholipase activity
calcium-dependent phospholipase A2 activity
metal ion binding
Process
metabolic process
organophosphate metabolic process
phospholipid metabolic process
phospholipid catabolic process

Cellular Location

Cytoplasm
Peripheral membrane protein
Cytoplasmic side
Lysosome membrane
cytosol

Pathways

Name	SMPDB/Pathwhiz	KEGG
Glycerophospholipid metabolism	Not Available
Ether lipid metabolism	Not Available
Linoleic acid metabolism	Not Available
alpha-Linolenic acid metabolism	Not Available
MAPK signaling pathway	Not Available

Gene Properties

Chromosome Location

Locus

15q15.1

SNPs

PLA2G4F

Gene Sequence

>2550 bp
ATGCTTTGGGCACTCTGGCCAAGGTGGCTGGCAGACAAGATGCTGCCCCTCCTGGGGGCA
GTGCTGCTTCAGAAGAGAGAGAAGAGGGGCCCTCTGTGGAGGCACTGGCGGCGGGAAACC
TACCCATACTATGACCTCCAGGTGAAGGTGCTGAGGGCCACAAACATCCGGGGCACAGAC
CTGCTGTCCAAAGCCGACTGCTATGTGCAACTGTGGCTGCCCACGGCGTCCCCAAGCCCT
GCCCAGACTAGGATAGTGGCCAACTGCAGTGACCCCGAGTGGAATGAGACCTTCCACTAC
CAGATCCATGGTGCTGTGAAGAACGTCCTGGAGCTCACCCTCTATGACAAGGACATCCTG
GGCAGCGACCAGCTCTCTCTGCTCCTGTTTGACCTGAGAAGCCTCAAGTGTGGCCAACCT
CACAAACACACCTTCCCACTCAACCACCAGGATTCACAAGAGCTGCAGGTGGAATTTGTT
CTGGAGAAGAGCCAGGTGCCTGCATCTGAAGTCATCACCAACGGGGTTCTGGTGGCTCAC
CCCTGTCTGAGAATCCAGGGCACGCTCCGGGGAGATGGGACAGCCCCACGGGAAGAGTAC
GGCTCTAGGCAGCTCCAGCTGGCAGTGCCTGGAGCCTACGAGAAGCCACAGCTCTTGCCC
CTGCAGCCTCCCACAGAGCCAGGCCTCCCACCCACCTTTACCTTCCACGTGAACCCAGTG
CTGAGCTCCAGGCTACACGTGGAGCTGATGGAGCTGCTGGCAGCTGTGCAGAGTGGCCCC
AGCGCAGAGTTGGAGGCTCAGACCAGCAAGCTGGGCGAGGGGGGCATCCTGCTCTCCTCT
CTGCCCCTAGGCCAGGAGGAACAGTGTTCTGTGGCCCTGGGGGAGGGCCAGGAGGTGGCT
CTGAGCATGAAGGTGGAAATGAGCTCCGGGGACCTAGACCTACGCCTTGGCTTTGACCTC
TCTGACGGGGAGCAGGAGTTTCTGGACAGGAGGAAGCAGGTCGTGTCCAAGGCCCTGCAG
CAAGTGCTGGGATTGAGTGAGGCTCTGGACAGTGGCCAGGTGCCTGTAGTGGCTGTGTTG
GGTTCCGGGGGTGGAACCCGAGCCATGTCTTCTCTGTACGGCAGCCTGGCAGGGTTGCAG
GAGCTCGGCCTTCTAGACACTGTGACCTACCTGAGTGGGGTCTCTGGGTCTACCTGGTGC
ATCTCCACACTCTACAGGGACCCAGCCTGGTCCCAGGTGGCCTTGCAGGGCCCCATTGAG
CGTGCCCAGGTTCACGTCTGCAGCAGTAAGATGGGAGCTTTGTCCACGGAGCGGCTACAG
TACTACACTCAGGAACTGGGGGTCCGGGAGCGCAGTGGCCACAGCGTGTCCCTCATCGAC
CTCTGGGGCCTCCTTGTTGAGTATCTCCTGTACCAGGAGGAGAACCCTGCCAAGCTGTCT
GACCAACAGGAGGCGGTCCGCCAGGGTCAGAACCCTTACCCCATTTACACCAGTGTCAAC
GTCCGCACCAACTTGAGTGGGGAAGATTTTGCAGAGTGGTGCGAGTTCACGCCCTATGAG
GTTGGCTTCCCCAAGTACGGGGCTTATGTTCCCACCGAGCTCTTCGGCTCAGAACTCTTC
ATGGGACGATTGCTGCAGCTCCAGCCTGAACCCCGGATCTGTTACCTGCAAGGTATGTGG
GGCAGCGCCTTTGCCACCAGCCTGGATGAGATCTTCCTAAAGACCGCCGGCTCGGGCCTC
AGCTTCCTGGAGTGGTACAGAGGCAGTGTGAATATCACAGACGACTGCCAGAAGCCTCAG
CTGCACAACCCCTCGAGGCTGCGAACGAGGCTCCTCACCCCACAGGGGCCCTTCTCCCAG
GCTGTGCTGGACATATTCACCTCCCGCTTCACTTCCGCCCAGAGCTTTAACTTCACCCGG
GGTCTCTGCTTGCACAAGGACTATGTGGCTGGCAGGGAGTTCGTGGCCTGGAAAGACACA
CACCCGGACGCCTTCCCCAACCAGCTCACCCCCATGCGGGACTGCCTGTACCTGGTGGAC
GGAGGCTTTGCCATCAACTCTCCGTTCCCACTGGCTCTGCTGCCTCAGAGAGCAGTGGAC
CTCATTCTGTCCTTTGACTATTCCTTGGAAGCCCCTTTTGAGGTCTTGAAGATGACAGAG
AAGTACTGCCTGGACCGAGGAATCCCCTTCCCTAGCATCGAGGTGGGCCCTGAGGACATG
GAGGAGGCCCGTGAGTGCTATCTGTTTGCCAAGGCTGAGGACCCCCGCTCCCCCATTGTG
CTGCACTTCCCCCTGGTTAACCGTACCTTCCGCACACACCTGGCCCCAGGTGTGGAGCGA
CAAACAGCTGAGGAGAAGGCCTTTGGGGACTTTGTCATCAACAGGCCAGACACCCCCTAT
GGCATGATGAACTTCACCTATGAGCCCCAGGACTTTTATCGGCTGGTGGCCCTCAGTCGA
TACAACGTCCTGAACAACGTGGAGACCTTGAAGTGCGCCCTCCAGCTGGCTCTGGACCGG
CACCAGGCTCGGGAGAGGGCAGGGGCCTGA

Protein Properties

Number of Residues

849

Molecular Weight

95081.5

Theoretical pI

5.439

Pfam Domain Function

C2 (PF00168 )
PLA2_B (PF01735 )

Signals

Not Available

Transmembrane Regions

Not Available

Protein Sequence

>Cytosolic phospholipase A2 zeta
MLWALWPRWLADKMLPLLGAVLLQKREKRGPLWRHWRRETYPYYDLQVKVLRATNIRGTD
LLSKADCYVQLWLPTASPSPAQTRIVANCSDPEWNETFHYQIHGAVKNVLELTLYDKDIL
GSDQLSLLLFDLRSLKCGQPHKHTFPLNHQDSQELQVEFVLEKSQVPASEVITNGVLVAH
PCLRIQGTLRGDGTAPREEYGSRQLQLAVPGAYEKPQLLPLQPPTEPGLPPTFTFHVNPV
LSSRLHVELMELLAAVQSGPSAELEAQTSKLGEGGILLSSLPLGQEEQCSVALGEGQEVA
LSMKVEMSSGDLDLRLGFDLSDGEQEFLDRRKQVVSKALQQVLGLSEALDSGQVPVVAVL
GSGGGTRAMSSLYGSLAGLQELGLLDTVTYLSGVSGSTWCISTLYRDPAWSQVALQGPIE
RAQVHVCSSKMGALSTERLQYYTQELGVRERSGHSVSLIDLWGLLVEYLLYQEENPAKLS
DQQEAVRQGQNPYPIYTSVNVRTNLSGEDFAEWCEFTPYEVGFPKYGAYVPTELFGSELF
MGRLLQLQPEPRICYLQGMWGSAFATSLDEIFLKTAGSGLSFLEWYRGSVNITDDCQKPQ
LHNPSRLRTRLLTPQGPFSQAVLDIFTSRFTSAQSFNFTRGLCLHKDYVAGREFVAWKDT
HPDAFPNQLTPMRDCLYLVDGGFAINSPFPLALLPQRAVDLILSFDYSLEAPFEVLKMTE
KYCLDRGIPFPSIEVGPEDVEEARECYLFAKAEDPRSPIVLHFPLVNRTFRTHLAPGVER
QTAEEKAFGDFVINRPDTPYGMMNFTYEPQDFYRLVALSRYNVLNNVETLKCALQLALDR
HQARERAGA

External Links

GenBank ID Protein

281371376

UniProtKB/Swiss-Prot ID

Q68DD2

UniProtKB/Swiss-Prot Entry Name

PA24F_HUMAN

PDB IDs

Not Available

GenBank Gene ID

NM_213600.3

GeneCard ID