| Identification |
|---|
| HMDB Protein ID
| CDBP03078 |
| Secondary Accession Numbers
| Not Available |
| Name
| Cytosolic phospholipase A2 epsilon |
| Description
| Not Available |
| Synonyms
|
- Phospholipase A2 group IVE
- cPLA2-epsilon
|
| Gene Name
| PLA2G4E |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in metabolic process |
| Specific Function
| Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position (By similarity).
|
| GO Classification
|
| Biological Process |
| phosphatidylcholine acyl-chain remodeling |
| phosphatidylethanolamine acyl-chain remodeling |
| phosphatidylinositol acyl-chain remodeling |
| phosphatidylserine acyl-chain remodeling |
| phospholipid catabolic process |
| glycerophospholipid biosynthetic process |
| Cellular Component |
| cytosol |
| lysosomal membrane |
| Function |
| lipase activity |
| phospholipase activity |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| Molecular Function |
| phospholipase A2 activity |
| metal ion binding |
| Process |
| metabolic process |
| organophosphate metabolic process |
| phospholipid metabolic process |
| phospholipid catabolic process |
|
| Cellular Location
|
- Cytoplasm
- Peripheral membrane protein
- Cytoplasmic side
- Lysosome membrane
- cytosol
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glycerophospholipid metabolism | Not Available |  | | Ether lipid metabolism | Not Available |  | | Linoleic acid metabolism | Not Available |  | | alpha-Linolenic acid metabolism | Not Available |  | | MAPK signaling pathway | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 15 |
| Locus
| 15q15.1 |
| SNPs
| PLA2G4E |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 838 |
| Molecular Weight
| 99189.335 |
| Theoretical pI
| 5.648 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Cytosolic phospholipase A2 epsilon
MLLRQMHARVSHSLPDPCQAEDSRPSATCALKAPQTSWDGLLREGLSPCHLLTVRVIRMK
NVRQADMLSQTDCFVSLWLPTASQKKLRTRTISNCPNPEWNESFNFQIQSRVKNVLELSV
CDEDTVTPDDHLLTVLYDLTKLCFRKKTHVKFPLNPQGMEELEVEFLLEESPSPPETLVT
NGVLVSRGHGWLLLSGEQDQGRKQWAKDLLVMVNESFENTQRVRPCLEPCCPTSACFHYP
KYFQSQVHVEVPKSHWSCGLCCRSRKKGPISQPLDCLSDGQVMTLPVGGGESLGSPETLD
VRLGFSLCPAELEFLQKRKVVVAKALKQVLQLEEDLQEDEVPLIAIMATGGGTRSMTSMY
GHLLGLQKLNLLDCASYITGLSGATWTMATLYRDPDWSSKNLEPAIFEARRHVVKDKLPS
LFPDQLRKFQEELRQRSQEGYRVTFTDFWGLLIETCLGDERNECKLSDQRAALSCGQNPL
PIYLTINVKDDVSNQDFREWFEFSPYEVGLQKYGAFIPSELFGSEFFMGRLVKRIPESRI
CYMLGLWSSIFSLNLLDAWNLSHTSEEFFHRWTREKVQDIEDEPILPEIPKCDANILETT
VVIPGSWLSNSFREILTHRSFVSEFHNFLSGLQLHTNYLQNGQFSRWKDTVLDGFPNQLT
ESANHLCLLDTAFFVNSSYPPLLRPERKADLIIHLNYCAGSQTKPLKQTCEYCTVQNIPF
PKYELPDENENLKECYLMENPQEPDAPIVTFFPLINDTFRKYKAPGVERSPEELEQGQVD
IYGPKTPYATKELTYTEATFDKLVKLSEYNILNNKDTLLQALRLAVEKKKRLKGQCPS
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q3MJ16 |
| UniProtKB/Swiss-Prot Entry Name
| PA24E_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| PLA2G4E |
| GenAtlas ID
| PLA2G4E |
| HGNC ID
| HGNC:24791 |
| References |
|---|
| General References
| Not Available |