| Identification |
|---|
| HMDB Protein ID
| CDBP03077 |
| Secondary Accession Numbers
| Not Available |
| Name
| Cytosolic phospholipase A2 delta |
| Description
| Not Available |
| Synonyms
|
- Phospholipase A2 group IVD
- cPLA2-delta
|
| Gene Name
| PLA2G4D |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in metabolic process |
| Specific Function
| Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position. Not arachidonic acid-specific but has linoleic acid-specific activity. May play a role in inflammation in psoriatic lesions.
|
| GO Classification
|
| Biological Process |
| phosphatidic acid biosynthetic process |
| phosphatidylglycerol acyl-chain remodeling |
| phosphatidylcholine acyl-chain remodeling |
| phosphatidylethanolamine acyl-chain remodeling |
| phosphatidylinositol acyl-chain remodeling |
| phosphatidylserine acyl-chain remodeling |
| phospholipid catabolic process |
| Cellular Component |
| cytosol |
| cytoplasmic vesicle membrane |
| Function |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| lipase activity |
| phospholipase activity |
| Molecular Function |
| phospholipase A2 activity |
| metal ion binding |
| Process |
| metabolic process |
| organophosphate metabolic process |
| phospholipid metabolic process |
| phospholipid catabolic process |
|
| Cellular Location
|
- Cytoplasm
- Peripheral membrane protein
- Cytoplasmic side
- cytosol
- Cytoplasmic vesicle membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Glycerophospholipid metabolism | Not Available |  | | Ether lipid metabolism | Not Available |  | | Linoleic acid metabolism | Not Available |  | | alpha-Linolenic acid metabolism | Not Available |  | | MAPK signaling pathway | Not Available |  |
|
| Gene Properties |
|---|
| Chromosome Location
| 15 |
| Locus
| 15q15.1 |
| SNPs
| PLA2G4D |
| Gene Sequence
|
>2457 bp
ATGGAGAGCCTGTCACCTGGGGGACCAACTGGCCACCCTTACCAGGGGGAGGCCTCTACC
TGCTGGCAGCTCACAGTGAGGGTCCTGGAGGCGCGGAACCTGCGCTGGGCTGACCTGTTG
AGTGAGGCCGACCCTTACGTGATCCTACAGCTGTCGACCGCACCTGGAATGAAGTTTAAG
ACCAAGACGCTCACCGACACCAGTCATCCTGTGTGGAATGAGGCCTTCCGTTTCCTTATC
CAAAGTCAGGTCAAGAATGTTCTGGAGCTTAGCATCTATGATGAGGACTCAGTCACGGAG
GATGACATCTGCTTCAAGGTTCTCTATGACATCTCAGAAGTCCTCCCTGGCAAGCTGCTC
CGGAAAACCTTCTCCCAGAGTCCCCAGGGAGAGGAGGAGCTGGATGTGGAGTTCCTGATG
GAAGAAACGTCAGATCGCCCAGAAAACCTCATCACCAACAAAGTCATTGTGGCCCGAGAG
CTGTCATGCCTGGATGTGCATCTGGACAGCACAGGGAGCACCGCTGTGGTTGCAGATCAG
GACAAGCTGGAGCTGGAGCTGGTGCTGAAGGGGTCCTATGAGGACACACAGACATCCTTC
CTGGGCACAGCCTCTGCCTTCCGCTTCCACTACATGGCAGCCCTAGAGACAGAGCTGAGC
GGGCGCCTGAGGAGCTCCAGAAGCAATGGCTGGAATGGGGACAACTCAGCTGGGTACCTC
ACTGTGCCCCTGAGGCCCTTGACCATTGGGAAGGAGGTGACTATGGATGTTCCTGCTCCA
AATGCCCCAGGAGTGAGGCTGCAGCTCAAGGCAGAGGGCTGCCCTGAGGAGCTGGCCGTG
CACCTGGGCTTCAATCTCTGTGCAGAGGAGCAGGCCTTCCTGAGCAGGAGGAAGCAGGTG
GTGGCCAAGGCCCTGAAGCAGGCCCTGCAGCTGGACAGAGACCTGCAGGAGGATGAGGTA
CCCGTTGTGGGCATCATGGCCACAGGAGGAGGTGCCCGGGCCATGACCTCACTCTACGGC
CACCTATTGGCCTTGCAGAAGCTGGGCCTCCTAGACTGTGTGACCTACTTCAGTGGCATC
TCTGGCTCTACGTGGACAATGGCCCACCTGTACGGGGACCCTGAGTGGTCGCAGAGGGAC
CTGGAGGGACCTATCAGATACGCCCGGGAGCACCTGGCCAAGAGCAAGCTGGAGGTCTTT
TCCCCAGAGCGCCTGGCGAGCTACCGCCGGGAGCTGGAGCTGCGGGCTGAGCAGGGCCAC
CCCACGACCTTTGTGGACCTGTGGGCGCTAGTGCTGGAGTCCATGCTGCACGGCCAGGTG
ATGGATCAGAAGCTGTCAGGACAGAGAGCCGCCCTGGAACGGGGTCAGAACCCTCTGCCC
CTCTACTTGAGCCTCAATGTCAAAGAGAACAATCTGGAGACACTGGACTTCAAGGAGTGG
GTTGAGTTCTCCCCCTATGAGGTCGGTTTCCTGAAGTACGGGGCCTTCGTCCCTCCTGAG
CTCTTCGGCTCCGAGTTCTTCATGGGACGGCTGATGAGGAGGATCCCGGAGCCCCGGATC
TGCTTTCTGGAAGCCATCTGGAGCAACATTTTCTCCCTGAACCTGCTGGATGCCTGGTAT
GACCTCACCAGTTCTGGGGAGTCCTGGAAACAGCACATCAAGGACAAGACCAGGAGCTTA
GAGAAGGAGCCCCTGACCACCTCGGGGACCTCCTCGCGGCTGGAGGCCTCGTGGCTGCAG
CCAGGCACGGCGCTGGCCCAGGCATTTAAAGGCTTCCTGACAGGCAGGCCCCTCCACCAG
CGCAGCCCCAACTTCCTCCAGGGCCTCCAGCTGCACCAGGACTACTGTAGCCACAAAGAC
TTCTCCACCTGGGCAGACTACCAGCTTGACTCCATGCCCAGCCAGCTGACCCCCAAGGAG
CCCCGGCTCTGCCTGGTGGACGCCGCCTACTTCATCAACACCAGCTCTCCCTCCATGTTC
CGGCCAGGCCGCAGGCTGGACCTCATCCTCTCCTTCGACTACTCCCTATCTGCGCCCTTC
GAGGCACTGCAGCAGACGGAGCTGTACTGCCGGGCCCGGGGGCTGCCCTTCCCCCGGGTG
GAACCCAGCCCTCAGGACCAGCACCAGCCAAGGGAATGCCACCTCTTCTCAGACCCCGCC
TGCCCCGAGGCCCCGATCCTGCTGCACTTCCCGCTGGTCAATGCCTCCTTCAAGGACCAC
TCAGCCCCCGGTGTCCAGCGCAGCCCCGCAGAGCTCCAGGGTGGCCAAGTGGATCTCACC
GGGGCCACCTGCCCCTACACCCTGTCCAACATGACCTACAAGGAGGAAGACTTCGAGCGC
CTGCTGCGGCTCAGTGACTACAACGTGCAGACCAGCCAGGGTGCCATCCTGCAGGCCCTG
AGGACCGCGCTGAAGCACCGGACTCTAGAGGCGAGGCCTCCAAGGGCACAGACCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 818 |
| Molecular Weight
| 91951.405 |
| Theoretical pI
| 5.503 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
>Cytosolic phospholipase A2 delta
MESLSPGGPPGHPYQGEASTCWQLTVRVLEARNLRWADLLSEADPYVILQLSTAPGMKFK
TKTLTDTSHPVWNEAFRFLIQSQVKNVLELSIYDEDSVTEDDICFKVLYDISEVLPGKLL
RKTFSQSPQGEEELDVEFLMEETSDRPENLITNKVIVARELSCLDVHLDSTGSTAVVADQ
DKLELELVLKGSYEDTQTSFLGTASAFRFHYMAALETELSGRLRSSRSNGWNGDNSAGYL
TVPLRPLTIGKEVTMDVPAPNAPGVRLQLKAEGCPEELAVHLGFNLCAEEQAFLSRRKQV
VAKALKQALQLDRDLQEDEVPVVGIMATGGGARAMTSLYGHLLALQKLGLLDCVTYFSGI
SGSTWTMAHLYGDPEWSQRDLEGPIRYAREHLAKSKLEVFSPERLASYRRELELRAEQGH
PTTFVDLWALVLESMLHGQVMDQKLSGQRAALERGQNPLPLYLSLNVKENNLETLDFKEW
VEFSPYEVGFLKYGAFVPPELFGSEFFMGRLMRRIPEPRICFLEAIWSNIFSLNLLDAWY
DLTSSGESWKQHIKDKTRSLEKEPLTTSGTSSRLEASWLQPGTALAQAFKGFLTGRPLHQ
RSPNFLQGLQLHQDYCSHKDFSTWADYQLDSMPSQLTPKEPRLCLVDAAYFINTSSPSMF
RPGRRLDLILSFDYSLSAPFEALQQTELYCRARGLPFPRVEPSPQDQHQPRECHLFSDPA
CPEAPILLHFPLVNASFKDHSAPGVQRSPAELQGGQVDLTGATCPYTLSNMTYKEEDFER
LLRLSDYNVQTSQGAILQALRTALKHRTLEARPPRAQT
|
| External Links |
|---|
| GenBank ID Protein
| 29467442 |
| UniProtKB/Swiss-Prot ID
| Q86XP0 |
| UniProtKB/Swiss-Prot Entry Name
| PA24D_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB090876 |
| GeneCard ID
| PLA2G4D |
| GenAtlas ID
| PLA2G4D |
| HGNC ID
| HGNC:30038 |
| References |
|---|
| General References
| Not Available |