| Identification |
|---|
| HMDB Protein ID
| CDBP03072 |
| Secondary Accession Numbers
| Not Available |
| Name
| Otopetrin-1 |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| OTOP1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in biomineral formation |
| Specific Function
| Required for normal formation of otoconia in the inner ear. Inhibits P2Y purinoceptors. Modulates calcium homeostasis and influx of calcium in response to extracellular ATP |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Secreted
- Membrane
- extracellular space
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:4 |
| Locus
| 4p16.3 |
| SNPs
| OTOP1 |
| Gene Sequence
|
>1839 bp
ATGCTCGAGGGCCTGGGGTCGCCCGCCTCGCCCCGGGCAGCTGCAAGCGCCTCGGTCGCA
GGGTCGTCGGGGCCAGCGGCCTGCTCGCCTCCCTCGTCCTCGGCCCCGAGGTCCCCGAAA
TCCCCGGCCCCCCGGCGGGGCGGTGTGCGCGCCAGCGTCCCACAGAAACTGGCCGAGATG
CTGAGCAGCCAGTATGGGCTGATCGTGTTCGTGGCGGGGCTGCTGCTGCTGCTGGCCTGG
GCCGTGCACGCCGCGGGCGTGAGCAAGAGCGACCTGCTGTGCTTCCTGACGGCGCTCATG
CTGCTGCAGCTGCTGTGGATGCTGTGGTACGTGGGCCGCAGCTCCGCGCACCGCCGCCTC
TTCCGCCTCAAGGACACGCACGCGGGTGCCGGCTGGCTGCGCGGTAGTATCACATTGTTT
GCAGTCATTACCGTCATCCTGGGATGCCTTAAAATTGGATACTTCATTGGATTTTCAGAA
TGTTTATCAGCCACTGAAGGAGTTTTCCCAGTCACCCATTCAGTGCATACTTTGTTGCAG
GTATATTTTCTTTGGGGGCATGCAAAGGATATTATCCAGTCTTTCAAAACACTGGAAAGG
TTTGGAGTGATCCACTCGGTGTTCACCAACCTGCTTCTGTGGGCCAATGGCGTCCTCAAT
GAGTCAAAGCACCAACTCAATGAGCACAAGGAACGGCTCATCACTCTGGGTTTTGGGAAC
ATAACAACAGTTTTAGATGACCACACACCGCAGTGTAACTGCACGCCCCCAACTCTGTGC
ACTGCCATCTCCCACGGGATCTACTACCTCTACCCCTTCAACATAGAGTATCAGATCCTG
GCCTCCACAATGCTCTACGTCCTGTGGAAGAACATCGGGCGCAAAGTTGACAGCCATCAG
CACCAGAAGATGCAGTTCAAGTCTGATGGGGTCATGGTGGGCGCAGTCCTGGGCCTGACC
GTGCTGGCCGCCACCATTGCTGTGGTGGTGGTATACCTGATTCATATTGGGCGCTCCAAG
ACCAAGAGCGAGTCGGCACTCATCATGTTCTACCTGTATGCCATCACCCTGCTGATGCTT
ATGGGGGCTGCGGGGCTGGCTGGAATCCGGATTTACAGGATAGACGAGAAGTCACTGGAT
GAGTCCAAAAATCCGGCCCGCAAACTGGACTCGGACCTCTTGGTGGGCACTGCCTCGGGC
TCCTGGCTTATCTCCTGGGGCTCAATCTTGGCCATCCTCTGTGCTGAGGGCCACCCCCGC
TACACCTGGTACAACCTGCCCTACTCCATCCTGGCGATCGTGGAGAAGTACATCCAGAAC
CTCTTCATCTTTGAATCCATTCACCGAGAGCCTGAAAAACTCTCTGAGGACATCCAAACC
CTTCGGGTGGTCACAGTCTGCAATGGCAACACCATGCCCCTTGCTTCTTCCTGCCCCAAG
AGTGGAGGTGTGGCCAGAGATGTGGCTCCCCAGGGCAAGGACATGCCACCAGCAGCCAAT
GGAAATGTGTGCATGAGAGAAAGCCATGACAAGGAGGAGGAGAAGCAGGAGGAGAGCAGC
TGGGGAGGGAGCCCAAGCCCAGTCCGCCTTCCCCGTTTCTTACAGGGCAACGCCAAGAGA
AAAGTCCTGAGGAATATTGCAGCCTTCTTGTTCCTCTGCAATATTTCGCTTTGGATACCT
CCCGCCTTTGGCTGTCGACCTGAGTATGACAATGGATTGGAGGAGATTGTCTTTGGCTTT
GAACCCTGGATAATTGTGGTCAACCTGGCCATGCCTTTTTCTATTTTCTATCGAATGCAC
GCAGCTGCCTCCCTCTTTGAGGTCTATTGTAAGATATAG
|
| Protein Properties |
|---|
| Number of Residues
| 612 |
| Molecular Weight
| 67352.8 |
| Theoretical pI
| 8.51 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["67-87", "92-112", "137-157", "168-188", "269-289", "311-331", "346-366", "393-413", "545-565", "576-596"]
|
| Protein Sequence
|
>Otopetrin-1
MLEGLGSPASPRAAASASVAGSSGPAACSPPSSSAPRSPESPAPRRGGVRASVPQKLAEM
LSSQYGLIVFVAGLLLLLAWAVHAAGVSKSDLLCFLTALMLLQLLWMLWYVGRSSAHRRL
FRLKDTHAGAGWLRGSITLFAVITVILGCLKIGYFIGFSECLSATEGVFPVTHSVHTLLQ
VYFLWGHAKDIIQSFKTLERFGVIHSVFTNLLLWANGVLNESKHQLNEHKERLITLGFGN
ITTVLDDHTPQCNCTPPTLCTAISHGIYYLYPFNIEYQILASTMLYVLWKNIGRKVDSHQ
HQKMQFKSDGVMVGAVLGLTVLAATIAVVVVYLIHIGRSKTKSESALIMFYLYAITLLML
MGAAGLAGIRIYRIDEKSLDESKNPARKLDSDLLVGTASGSWLISWGSILAILCAEGHPR
YTWYNLPYSILAIVEKYIQNLFIFESIHREPEKLSEDIQTLRVVTVCNGNTMPLASSCPK
SGGVARDVAPQGKDMPPAANGNVCMRESHDKEEEKQEESSWGGSPSPVRLPRFLQGNAKR
KVLRNIAAFLFLCNISLWIPPAFGCRPEYDNGLEEIVFGFEPWIIVVNLAMPFSIFYRMH
AAASLFEVYCKI
|
| External Links |
|---|
| GenBank ID Protein
| 120660054 |
| UniProtKB/Swiss-Prot ID
| Q7RTM1 |
| UniProtKB/Swiss-Prot Entry Name
| OTOP1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC130430 |
| GeneCard ID
| OTOP1 |
| GenAtlas ID
| OTOP1 |
| HGNC ID
| HGNC:19656 |
| References |
|---|
| General References
| Not Available |