| Identification |
|---|
| HMDB Protein ID
| CDBP03068 |
| Secondary Accession Numbers
| Not Available |
| Name
| Neurotensin receptor type 2 |
| Description
| Not Available |
| Synonyms
|
- Levocabastine-sensitive neurotensin receptor
- NT-R-2
- NTR2
|
| Gene Name
| NTSR2 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in G-protein coupled receptor protein signaling pathway |
| Specific Function
| Receptor for the tridecapeptide neurotensin. It is associated with G proteins that activate a phosphatidylinositol- calcium second messenger system |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| neuropeptide receptor activity |
| neurotensin receptor activity, g-protein coupled |
| receptor activity |
| molecular transducer activity |
| signal transducer activity |
| peptide receptor activity |
| peptide receptor activity, g-protein coupled |
| Process |
| signaling |
| signaling pathway |
| cell surface receptor linked signaling pathway |
| g-protein coupled receptor protein signaling pathway |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 2p25.1 |
| SNPs
| NTSR2 |
| Gene Sequence
|
>1233 bp
ATGGAAACCAGCAGCCCGCGGCCCCCGCGGCCCAGCTCCAACCCGGGGCTGAGCCTGGAC
GCCCGGCTGGGCGTGGACACTCGCCTCTGGGCCAAGGTGCTGTTCACCGCGCTCTACGCA
CTCATCTGGGCGCTGGGCGCGGCGGGCAATGCGCTGTCCGTGCACGTGGTGCTGAAGGCG
CGGGCCGGGCGCGCGGGGCGCCTGCGCCACCACGTGCTCAGCCTGGCGCTCGCGGGCCTG
CTGCTGCTGCTGGTCGGCGTGCCGGTGGAGCTCTACAGCTTCGTGTGGTTCCACTACCCC
TGGGTCTTCGGCGACCTGGGCTGCCGCGGCTACTACTTCGTGCACGAGCTGTGCGCCTAC
GCCACGGTGCTGAGCGTGGCAGGCCTGAGCGCCGAGCGCTGCCTAGCCGTGTGCCAGCCC
CTGCGTGCCCGCAGCCTGCTGACGCCACGCCGGACCCGGTGGCTGGTGGCGCTCTCGTGG
GCCGCCTCGCTCGGCCTCGCCCTGCCCATGGCCGTCATCATGGGGCAGAAGCACGAACTC
GAGACGGCGGACGGGGAGCCGGAGCCCGCCTCGCGAGTGTGCACGGTGCTGGTGAGCCGC
ACCGCGCTCCAAGTCTTTATCCAGGTGAATGTGCTGGTGTCCTTCGTGCTCCCCTTGGCA
CTAACTGCTTTCCTGAATGGGGTCACAGTGAGCCACCTGCTGGCCCTCTGCTCCCAAGTG
CCGTCCACTTCTACCCCGGGCAGCTCCACCCCCAGCCGCCTGGAGCTGCTGAGTGAGGAG
GGTCTCCTCAGCTTCATCGTATGGAAGAAGACCTTTATCCAGGGAGGCCAGGTCAGCCTG
GTGAGACATAAAGACGTGCGCCGGATCCGCAGCCTCCAGCGCAGCGTCCAGGTTCTCAGA
GCCATCGTGGTCATGTATGTCATCTGCTGGCTGCCGTACCATGCCCGCAGGCTCATGTAC
TGCTACGTACCTGATGACGCGTGGACTGACCCACTGTACAATTTCTACCACTACTTCTAC
ATGGTGACCAACACACTTTTCTACGTCAGCTCAGCTGTGACTCCTCTTCTCTACAACGCC
GTGTCCTCCTCCTTCAGAAAACTCTTCCTGGAAGCCGTCAGCTCCCTGTGTGGAGAGCAC
CACCCCATGAAGCGGTTACCCCCGAAGCCCCAGAGTCCCACCCTAATGGATACAGCTTCA
GGCTTTGGGGATCCCCCAGAAACCCGGACCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 410 |
| Molecular Weight
| 45412.7 |
| Theoretical pI
| 9.64 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["33-55", "65-87", "110-131", "155-176", "218-237", "298-318", "338-358"]
|
| Protein Sequence
|
>Neurotensin receptor type 2
METSSPRPPRPSSNPGLSLDARLGVDTRLWAKVLFTALYALIWALGAAGNALSVHVVLKA
RAGRAGRLRHHVLSLALAGLLLLLVGVPVELYSFVWFHYPWVFGDLGCRGYYFVHELCAY
ATVLSVAGLSAERCLAVCQPLRARSLLTPRRTRWLVALSWAASLGLALPMAVIMGQKHEL
ETADGEPEPASRVCTVLVSRTALQVFIQVNVLVSFVLPLALTAFLNGVTVSHLLALCSQV
PSTSTPGSSTPSRLELLSEEGLLSFIVWKKTFIQGGQVSLVRHKDVRRIRSLQRSVQVLR
AIVVMYVICWLPYHARRLMYCYVPDDAWTDPLYNFYHYFYMVTNTLFYVSSAVTPLLYNA
VSSSFRKLFLEAVSSLCGEHHPMKRLPPKPQSPTLMDTASGFGDPPETRT
|
| External Links |
|---|
| GenBank ID Protein
| 3901028 |
| UniProtKB/Swiss-Prot ID
| O95665 |
| UniProtKB/Swiss-Prot Entry Name
| NTR2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Y10148 |
| GeneCard ID
| NTSR2 |
| GenAtlas ID
| NTSR2 |
| HGNC ID
| HGNC:8040 |
| References |
|---|
| General References
| Not Available |