Cannabis Compound Database: Showing Protein Neuropeptide FF receptor 2 (CDBP03062)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP03062

Secondary Accession Numbers

Not Available

Name

Neuropeptide FF receptor 2

Description

Not Available

Synonyms

G-protein coupled receptor 74
G-protein coupled receptor HLWAR77
Neuropeptide G-protein coupled receptor

Gene Name

NPFFR2

Protein Type

Receptor

Biological Properties

General Function

Involved in G-protein coupled receptor protein signaling pathway

Specific Function

Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol- calcium second messenger system

GO Classification

Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
peptide receptor activity
peptide receptor activity, g-protein coupled
neuropeptide receptor activity
receptor activity
molecular transducer activity
signal transducer activity
Process
signaling
signaling pathway
cell surface receptor linked signaling pathway
g-protein coupled receptor protein signaling pathway

Cellular Location

Cell membrane
Multi-pass membrane protein

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:4

Locus

4q21

SNPs

NPFFR2

Gene Sequence

>1569 bp
ATGAATAGCTTCTTCGGAACCCCAGCGGCCAGCTGGTGCCTCCTGGAAAGTGACGTCTCA
TCTGCACCGGACAAGGAGGCGGGGAGGGAGCGCAGAGCACTCAGCGTCCAGCAGCGCGGC
GGGCCAGCCTGGAGCGGAAGCCTGGAGTGGAGCAGGCAGTCCGCGGGGGACAGACGTCGG
CTGGGATTGAGCCGGCAGACTGCGAAAAGTAGCTGGAGCCGGAGCAGGGACAGAACCTGT
TGCTGCAGACGGGCTTGGTGGATTCTGGTTCCTGCCGCCGACAGGGCTCGCCGGGAGAGG
TTCATCATGAATGAGAAATGGGACACAAACTCTTCAGAAAACTGGCATCCCATCTGGAAT
GTCAATGACACAAAGCATCATCTGTACTCAGATATTAATATTACCTATGTGAACTACTAT
CTTCACCAGCCTCAAGTGGCAGCAATCTTCATTATTTCCTACTTTCTGATCTTCTTTTTG
TGCATGATGGGAAATACTGTGGTTTGCTTTATTGTAATGAGGAACAAACATATGCACACA
GTCACTAATCTCTTCATCTTAAACCTGGCCATAAGTGATTTACTAGTTGGCATATTCTGC
ATGCCTATAACACTGCTGGACAATATTATAGCAGGATGGCCATTTGGAAACACGATGTGC
AAGATCAGTGGATTGGTCCAGGGAATATCTGTCGCAGCTTCAGTCTTTACGTTAGTTGCA
ATTGCTGTAGATAGGTTCCAGTGTGTGGTCTACCCTTTTAAACCAAAGCTCACTATCAAG
ACAGCGTTTGTCATTATTATGATCATCTGGGTCCTAGCCATCACCATTATGTCTCCATCT
GCAGTAATGTTACATGTGCAAGAAGAAAAATATTACCGAGTGAGACTCAACTCCCAGAAT
AAAACCAGTCCAGTCTACTGGTGCCGGGAAGACTGGCCAAATCAGGAAATGAGGAAGATC
TACACCACTGTGCTGTTTGCCAACATCTACCTGGCTCCCCTCTCCCTCATTGTCATCATG
TATGGAAGGATTGGAATTTCACTCTTCAGGGCTGCAGTTCCTCACACAGGCAGGAAGAAC
CAGGAGCAGTGGCACGTGGTGTCCAGGAAAAAGCAGAAGATCATTAAGATGCTCCTGATT
GTGGCCCTGCTTTTTATTCTCTCATGGCTGCCCCTGTGGACTCTAATGATGCTCTCAGAC
TACGCTGACCTTTCTCCAAATGAACTGCAGATCATCAACATCTACATCTACCCTTTTGCA
CACTGGCTGGCATTCGGCAACAGCAGTGTCAATCCCATCATTTATGGTTTCTTCAACGAG
AATTTCCGCCGTGGTTTCCAAGAAGCTTTCCAGCTCCAGCTCTGCCAAAAAAGAGCAAAG
CCTATGGAAGCTTATACCCTAAAAGCTAAAAGCCATGTGCTCATAAACACATCTAATCAG
CTTGTCCAGGAATCTACATTTCAAAACCCTCATGGGGAAACCTTGCTTTATAGGAAAAGT
GCTGAAAAACCCCAACAGGAATTAGTGATGGAAGAATTAAAAGAAACTACTAACAGCAGT
GAGATTTAA

Protein Properties

Number of Residues

522

Molecular Weight

60269.7

Theoretical pI

9.69

Pfam Domain Function

7tm_1 (PF00001 )

Signals

["None"]

Transmembrane Regions

["148-168", "185-205", "222-242", "263-283", "320-340", "378-398", "414-434"]

Protein Sequence

>Neuropeptide FF receptor 2
MNSFFGTPAASWCLLESDVSSAPDKEAGRERRALSVQQRGGPAWSGSLEWSRQSAGDRRR
LGLSRQTAKSSWSRSRDRTCCCRRAWWILVPAADRARRERFIMNEKWDTNSSENWHPIWN
VNDTKHHLYSDINITYVNYYLHQPQVAAIFIISYFLIFFLCMMGNTVVCFIVMRNKHMHT
VTNLFILNLAISDLLVGIFCMPITLLDNIIAGWPFGNTMCKISGLVQGISVAASVFTLVA
IAVDRFQCVVYPFKPKLTIKTAFVIIMIIWVLAITIMSPSAVMLHVQEEKYYRVRLNSQN
KTSPVYWCREDWPNQEMRKIYTTVLFANIYLAPLSLIVIMYGRIGISLFRAAVPHTGRKN
QEQWHVVSRKKQKIIKMLLIVALLFILSWLPLWTLMMLSDYADLSPNELQIINIYIYPFA
HWLAFGNSSVNPIIYGFFNENFRRGFQEAFQLQLCQKRAKPMEAYALKAKSHVLINTSNQ
LVQESTFQNPHGETLLYRKSAEKPQQELVMEELKETTNSSEI

External Links

GenBank ID Protein

4530469

UniProtKB/Swiss-Prot ID

Q9Y5X5

UniProtKB/Swiss-Prot Entry Name

NPFF2_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF119815

GeneCard ID