| Identification |
|---|
| HMDB Protein ID
| CDBP03055 |
| Secondary Accession Numbers
| Not Available |
| Name
| Nuclear factor of activated T-cells, cytoplasmic 4 |
| Description
| Not Available |
| Synonyms
|
- NF-AT3
- NF-ATc4
- NFATc4
- T-cell transcription factor NFAT3
|
| Gene Name
| NFATC4 |
| Protein Type
| Transcription Factor |
| Biological Properties |
|---|
| General Function
| Involved in sequence-specific DNA binding transcription factor activity |
| Specific Function
| Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 and IL- 4. Transcriptionally repressed by estrogen receptors; this inhibition is further enhanced by estrogen. Increases the transcriptional activity of PPARG and has a direct role in adipocyte differentiation. May play an important role in myotube differentiation. May play a critical role in cardiac development and hypertrophy. May play a role in deafferentation-induced apoptosis of sensory neurons |
| GO Classification
|
| Component |
| organelle |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| nucleus |
| Function |
| sequence-specific dna binding transcription factor activity |
| Process |
| biological regulation |
| regulation of biological process |
| regulation of metabolic process |
| regulation of macromolecule metabolic process |
| regulation of gene expression |
| regulation of transcription |
| regulation of transcription, dna-dependent |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 14q11.2 |
| SNPs
| NFATC4 |
| Gene Sequence
|
>2709 bp
ATGGGGGCGGCCAGCTGCGAGGATGAGGAGCTGGAATTTAAGCTGGTGTTCGGGGAGGAA
AAGGAGGCCCCCCCGCTGGGCGCGGGGGGATTGGGGGAAGAACTGGACTCAGAGGATGCC
CCGCCATGCTGCCGTCTGGCCTTGGGAGAGCCCCCTCCCTATGGCGCTGCACCTATCGGT
ATTCCCCGACCTCCACCCCCTCGGCCTGGCATGCATTCGCCACCGCCGCGACCAGCCCCC
TCACCTGGCACCTGGGAGAGCCAGCCCGCCAGGTCGGTGAGGCTGGGAGGACCAGGAGGG
GGTGCTGGGGGTGCTGGGGGTGGCCGTGTTCTCGAGTGTCCCAGCATCCGCATCACCTCC
ATCTCTCCCACGCCGGAGCCGCCAGCAGCGCTGGAGGACAACCCTGATGCCTGGGGGGAC
GGCTCTCCTAGAGATTACCCCCCACCAGAAGGCTTTGGGGGCTACAGAGAAGCAGGGGGC
CAGGGTGGGGGGGCCTTCTTCAGCCCAAGCCCTGGCAGCAGCAGCCTGTCCTCGTGGAGC
TTCTTCTCCGATGCCTCTGACGAGGCAGCCCTGTATGCAGCCTGCGACGAGGTGGAGTCT
GAGCTAAATGAGGCGGCCTCCCGCTTTGGCCTGGGCTCCCCGCTGCCCTCGCCCCGGGCC
TCCCCTCGGCCATGGACCCCCGAAGATCCCTGGAGCCTGTATGGTCCAAGCCCCGGAGGC
CGAGGGCCAGAGGATAGCTGGCTACTCCTCAGTGCTCCTGGGCCCACCCCAGCCTCCCCG
CGGCCTGCCTCTCCATGTGGCAAGCGGCGCTATTCCAGCTCGGGAACCCCATCTTCAGCC
TCCCCAGCTCTGTCCCGCCGTGGCAGCCTGGGGGAAGAGGGGTCTGAGCCACCTCCACCA
CCCCCATTGCCTCTGGCCCGGGACCCGGGCTCCCCTGGTCCCTTTGACTATGTGGGGGCC
CCACCAGCTGAGAGCATCCCTCAGAAGACACGGCGGACTTCCAGCGAGCAGGCAGTGGCT
CTGCCTCGGTCTGAGGAGCCTGCCTCATGCAATGGGAAGCTGCCCTTGGGAGCAGAGGAG
TCTGTGGCTCCTCCAGGAGGTTCCCGGAAGGAGGTGGCTGGCATGGACTACCTGGCAGTG
CCCTCCCCACTCGCTTGGTCCAAGGCCCGGATTGGGGGACACAGCCCTATCTTCAGGACC
TCTGCCCTACCCCCACTGGACTGGCCTCTGCCCAGCCAATATGAGCAGCTGGAGCTGAGG
ATCGAGGTACAGCCTAGAGCCCACCACCGGGCCCACTATGAGACAGAAGGCAGCCGTGGA
GCTGTCAAAGCTGCCCCTGGCGGTCACCCCGTAGTCAAGCTCCTAGGCTACAGTGAGAAG
CCACTGACCCTACAGATGTTCATCGGCACTGCAGATGAAAGGAACCTGCGGCCTCATGCC
TTCTATCAGGTGCACCGTATCACAGGCAAGATGGTGGCCACGGCCAGCTATGAAGCCGTA
GTCAGTGGCACCAAGGTGTTGGAGATGACTCTGCTGCCTGAGAACAACATGGCGGCCAAC
ATTGACTGCGCGGGAATCCTGAAGCTTCGGAATTCAGACATTGAGCTTCGGAAGGGTGAG
ACGGACATCGGGCGCAAAAACACACGTGTACGGCTGGTGTTCCGGGTACACGTGCCCCAG
GGCGGCGGGAAGGTCGTCTCAGTACAGGCAGCATCGGTGCCCATCGAGTGCTCCCAGCGC
TCAGCCCAGGAGCTGCCCCAGGTGGAGGCCTACAGCCCCAGTGCCTGCTCTGTGAGAGGA
GGCGAGGAACTGGTACTGACTGGCTCCAACTTCCTGCCAGACTCCAAGGTGGTGTTCATT
GAGAGGGGTCCTGATGGGAAGCTGCAATGGGAGGAGGAGGCCACAGTGAACCGACTGCAG
AGCAACGAGGTGACGCTGACCCTGACTGTCCCCGAGTACAGCAACAAGAGGGTTTCCCGG
CCAGTCCAGGTCTACTTTTATGTCTCCAATGGGCGGAGGAAACGCAGTCCTACCCAGAGT
TTCAGGTTTCTGCCTGTGATCTGCAAAGAGGAGCCCCTACCGGACTCATCTCTGCGGGGT
TTCCCTTCAGCATCGGCAACCCCCTTTGGCACTGACATGGACTTCTCACCACCCAGGCCC
CCCTACCCCTCCTATCCCCATGAAGACCCTGCTTGCGAAACTCCTTACCTATCAGAAGGC
TTCGGCTATGGCATGCCCCCTCTGTACCCCCAGACGGGGCCCCCACCATCCTACAGACCG
GGCCTGCGGATGTTCCCTGAGACTAGGGGTACCACAGGTTGTGCCCAACCACCTGCAGTT
TCCTTCCTTCCCCGCCCCTTCCCTAGTGACCCGTATGGAGGGCGGGGCTCCTCTTTCTCC
CTGGGGCTGCCATTCTCTCCGCCAGCCCCCTTTCGGCCGCCTCCTCTTCCTGCATCCCCA
CCGCTTGAAGGCCCCTTCCCTTCCCAGAGTGATGTGCATCCCCTACCTGCTGAGGGATAC
AATAAGGTAGGGCCAGGCTATGGCCCTGGGGAGGGGGCTCCGGAGCAGGAGAAATCCAGG
GGTGGCTACAGCAGCGGCTTCCGAGACAGTGTCCCTATCCAGGGTATCACGCTGGAGGAA
GTGAGTGAGATCATTGGCCGAGACCTGAGTGGCTTCCCTGCACCTCCTGGAGAAGAGCCT
CCTGCCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 902 |
| Molecular Weight
| 95447.8 |
| Theoretical pI
| 5.05 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Nuclear factor of activated T-cells, cytoplasmic 4
MGAASCEDEELEFKLVFGEEKEAPPLGAGGLGEELDSEDAPPCCRLALGEPPPYGAAPIG
IPRPPPPRPGMHSPPPRPAPSPGTWESQPARSVRLGGPGGGAGGAGGGRVLECPSIRITS
ISPTPEPPAALEDNPDAWGDGSPRDYPPPEGFGGYREAGGQGGGAFFSPSPGSSSLSSWS
FFSDASDEAALYAACDEVESELNEAASRFGLGSPLPSPRASPRPWTPEDPWSLYGPSPGG
RGPEDSWLLLSAPGPTPASPRPASPCGKRRYSSSGTPSSASPALSRRGSLGEEGSEPPPP
PPLPLARDPGSPGPFDYVGAPPAESIPQKTRRTSSEQAVALPRSEEPASCNGKLPLGAEE
SVAPPGGSRKEVAGMDYLAVPSPLAWSKARIGGHSPIFRTSALPPLDWPLPSQYEQLELR
IEVQPRAHHRAHYETEGSRGAVKAAPGGHPVVKLLGYSEKPLTLQMFIGTADERNLRPHA
FYQVHRITGKMVATASYEAVVSGTKVLEMTLLPENNMAANIDCAGILKLRNSDIELRKGE
TDIGRKNTRVRLVFRVHVPQGGGKVVSVQAASVPIECSQRSAQELPQVEAYSPSACSVRG
GEELVLTGSNFLPDSKVVFIERGPDGKLQWEEEATVNRLQSNEVTLTLTVPEYSNKRVSR
PVQVYFYVSNGRRKRSPTQSFRFLPVICKEEPLPDSSLRGFPSASATPFGTDMDFSPPRP
PYPSYPHEDPACETPYLSEGFGYGMPPLYPQTGPPPSYRPGLRMFPETRGTTGCAQPPAV
SFLPRPFPSDPYGGRGSSFSLGLPFSPPAPFRPPPLPASPPLEGPFPSQSDVHPLPAEGY
NKVGPGYGPGEGAPEQEKSRGGYSSGFRDSVPIQGITLEEVSEIIGRDLSGFPAPPGEEP
PA
|
| External Links |
|---|
| GenBank ID Protein
| 27886563 |
| UniProtKB/Swiss-Prot ID
| Q14934 |
| UniProtKB/Swiss-Prot Entry Name
| NFAC4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_004554.4 |
| GeneCard ID
| NFATC4 |
| GenAtlas ID
| NFATC4 |
| HGNC ID
| HGNC:7778 |
| References |
|---|
| General References
| Not Available |