Showing Protein Neuronal calcium sensor 1 (CDBP03051)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP03051
Secondary Accession Numbers Not Available
Name Neuronal calcium sensor 1
Description Not Available
Synonyms
  1. Frequenin homolog
  2. Frequenin-like protein
  3. Frequenin-like ubiquitous protein
  4. NCS-1
Gene Name NCS1
Protein Type Metal Binding
Biological Properties
General Function Involved in calcium ion binding
Specific Function Neuronal calcium sensor, regulator of G protein-coupled receptor phosphorylation in a calcium dependent manner. Directly regulates GRK1 (RHOK), but not GRK2 to GRK5. Can substitute for calmodulin. Stimulates PI4KB kinase activity. Involved in long-term synaptic plasticity through its interaction with PICK1. May also play a role in neuron differentiation through inhibition of the activity of N- type voltage-gated calcium channel
GO Classification
Function
ion binding
cation binding
metal ion binding
binding
calcium ion binding
Cellular Location
  1. Cell membrane
  2. Cytoplasm
  3. perinuclear region
  4. Peripheral membrane protein
  5. Peripheral membrane protein
  6. Golgi apparatus
  7. Golgi stack membrane
  8. Cell junction
  9. synapse
  10. postsynaptic cell membrane
  11. postsynaptic density
Pathways
Gene Properties
Chromosome Location Chromosome:9
Locus 9q34
SNPs NCS1
Gene Sequence 
>573 bp
ATGGGGAAATCCAACAGCAAGTTGAAGCCCGAAGTTGTGGAGGAGCTGACCAGGAAGACC
TACTTTACCGAGAAGGAGGTCCAGCAGTGGTACAAAGGCTTCATCAAGGACTGCCCCAGT
GGGCAGCTGGATGCGGCAGGCTTCCAGAAGATCTACAAGCAATTCTTCCCGTTCGGAGAC
CCCACCAAGTTTGCCACATTTGTTTTCAACGTCTTTGATGAAAACAAGGACGGGCGAATT
GAGTTCTCCGAGTTCATCCAGGCGCTGTCGGTGACCTCACGGGGAACCCTGGATGAGAAG
CTACGGTGGGCCTTCAAGCTCTACGACTTGGACAATGATGGCTACATCACCAGGAATGAG
ATGCTGGACATTGTGGATGCCATTTACCAGATGGTGGGGAATACCGTGGAGCTCCCAGAG
GAGGAGAACACTCCTGAGAAGAGGGTGGACCGGATCTTTGCCATGATGGATAAGAATGCC
GACGGGAAGCTGACCCTGCAGGAGTTCCAGGAGGGTTCCAAGGCAGACCCGTCCATTGTG
CAGGCGCTGTCCCTCTACGACGGGCTGGTATAG
Protein Properties
Number of Residues 190
Molecular Weight 21878.6
Theoretical pI 4.44
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["None"]
Protein Sequence 
>Neuronal calcium sensor 1
MGKSNSKLKPEVVEELTRKTYFTEKEVQQWYKGFIKDCPSGQLDAAGFQKIYKQFFPFGD
PTKFATFVFNVFDENKDGRIEFSEFIQALSVTSRGTLDEKLRWAFKLYDLDNDGYITRNE
MLDIVDAIYQMVGNTVELPEEENTPEKRVDRIFAMMDKNADGKLTLQEFQEGSKADPSIV
QALSLYDGLV
GenBank ID Protein 9798526
UniProtKB/Swiss-Prot ID P62166
UniProtKB/Swiss-Prot Entry Name NCS1_HUMAN
PDB IDs
GenBank Gene ID X84048
GeneCard ID NCS1
GenAtlas ID NCS1
HGNC ID HGNC:3953
References
General References Not Available