Showing Protein Sodium/potassium/calcium exchanger 6 (CDBP03050)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP03050
Secondary Accession Numbers Not Available
Name Sodium/potassium/calcium exchanger 6
Description Not Available
Synonyms
  1. Na(+)/K(+)/Ca(2+)-exchange protein 6
  2. Solute carrier family 24 member 6
Gene Name SLC24A6
Protein Type Enzyme
Biological Properties
General Function Involved in transmembrane transport
Specific Function Transports Ca(2+) in exchange for either Li(+) or Na(+), explaining how Li(+) catalyzes Ca(2+) exchange. In contrast to other members of the family its function is independent of K(+)
GO Classification
Component
membrane part
intrinsic to membrane
integral to membrane
cell part
Process
establishment of localization
transport
transmembrane transport
Cellular Location
  1. Cell membrane
  2. Multi-pass membrane protein
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 12q24.13
SNPs SLC24A6
Gene Sequence 
>1755 bp
ATGGCCGGCAGAAGGCTGAATCTGCGCTGGGCACTGAGTGTGCTTTGTGTGCTGCTAATG
GCGGAGACAGTGTCTGGGACTAGGGGCTCGTCTACAGGAGCTCACATTAGCCCCCAGTTT
CCAGCTTCAGGTGTGAACCAGACCCCCGTGGTAGACTGCCGCAAGGTGTGTGGCCTGAAT
GTCTCTGACCGCTGTGACTTCATCCGGACCAACCCTGACTGCCACAGTGATGGGGGGTAC
CTGGACTACCTGGAAGGCATCTTCTGCCACTTCCCTCCCAGCCTCCTCCCTCTGGCTGTC
ACTCTCTACGTTTCCTGGCTGCTCTACCTGTTTCTGATTCTGGGAGTCACCGCAGCCAAG
TTTTTCTGCCCCAACTTGTCGGCCATTTCTACCACACTGAAGCTCTCCCACAACGTGGCA
GGCGTCACCTTCCTGGCATTTGGGAATGGTGCACCTGACATCTTCAGTGCCCTGGTGGCC
TTCTCTGACCCGCACACAGCCGGCCTGGCCCTTGGGGCACTGTTTGGCGCTGGCGTGCTG
GTTACCACAGTGGTGGCCGGAGGCATTACCATCCTACACCCCTTCATGGCTGCCTCCAGG
CCCTTCTTCAGGGACATCGTTTTCTACATGGTGGCTGTGTTCCTGACCTTCCTCATGCTC
TTCCGTGGCAGGGTCACCCTGGCATGGGCTCTGGGTTACCTGGGCTTGTATGTGTTCTAT
GTGGTCACTGTGATTCTCTGCACCTGGATCTACCAACGGCAACGGAGAGGATCTCTGTTC
TGCCCCATGCCAGTTACTCCAGAGATCCTCTCAGACTCCGAGGAGGACCGGGTATCTTCT
AATACCAACAGCTATGACTACGGTGATGAGTACCGGCCGCTGTTCTTCTACCAGGAGACC
ACGGCTCAGATCCTGGTCCGGGCCCTCAATCCCCTGGATTACATGAAGTGGAGAAGGAAA
TCAGCATACTGGAAAGCCCTCAAGGTGTTCAAGCTGCCTGTGGAGTTCCTGCTGCTCCTC
ACAGTCCCCGTCGTGGACCCGGACAAGGATGACCAGAACTGGAAACGGCCCCTCAACTGT
CTGCATCTGGTTATCAGCCCCCTGGTTGTGGTCCTGACCCTGCAGTCGGGGACCTATGGT
GTCTATGAGATAGGCGGCCTCGTTCCCGTCTGGGTCGTGGTGGTGATCGCAGGCACAGCC
TTGGCTTCAGTGACCTTTTTTGCCACATCTGACAGCCAGCCCCCCAGGCTTCACTGGCTC
TTTGCTTTCCTGGGCTTTCTGACCAGCGCCCTGTGGATCAACGCGGCCGCCACAGAGGTG
GTGAACATCTTGCGGTCCCTGGGTGTGGTCTTCCGGCTGAGCAACACTGTGCTGGGGCTC
ACGCTGCTGGCCTGGGGGAACAGCATTGGAGATGCCTTCTCGGATTTCACACTGGCTCGC
CAGGGCTACCCACGGATGGCGTTCTCCGCCTGCTTTGGCGGCATCATCTTCAACATCCTC
GTGGGTGTGGGGCTGGGCTGCCTGCTCCAGATCTCCCGAAGCCACACAGAAGTGAAGCTG
GAGCCAGACGGACTGCTGGTGTGGGTCCTGGCAGGCGCCCTGGGGCTCAGCCTCGTCTTC
TCCCTGGTCTCAGTCCCATTGCAGTGCTTCCAGCTCAGCAGAGTCTATGGCTTCTGCCTG
CTCCTCTTCTACCTGAACTTCCTTGTCGTGGCCCTCCTCACTGAATTTGGAGTGATTCAC
CTGAAAAGCATGTGA
Protein Properties
Number of Residues 584
Molecular Weight 64230.8
Theoretical pI 8.07
Pfam Domain Function
Signals
  • ["1-26"]
Transmembrane Regions
  • ["96-116", "141-161", "169-189", "201-221", "227-247", "326-346", "361-381", "384-404", "417-437", "446-466", "488-508", "525-545", "559-579"]
Protein Sequence 
>Sodium/potassium/calcium exchanger 6
MAGRRLNLRWALSVLCVLLMAETVSGTRGSSTGAHISPQFPASGVNQTPVVDCRKVCGLN
VSDRCDFIRTNPDCHSDGGYLDYLEGIFCHFPPSLLPLAVTLYVSWLLYLFLILGVTAAK
FFCPNLSAISTTLKLSHNVAGVTFLAFGNGAPDIFSALVAFSDPHTAGLALGALFGAGVL
VTTVVAGGITILHPFMAASRPFFRDIVFYMVAVFLTFLMLFRGRVTLAWALGYLGLYVFY
VVTVILCTWIYQRQRRGSLFCPMPVTPEILSDSEEDRVSSNTNSYDYGDEYRPLFFYQET
TAQILVRALNPLDYMKWRRKSAYWKALKVFKLPVEFLLLLTVPVVDPDKDDQNWKRPLNC
LHLVISPLVVVLTLQSGTYGVYEIGGLVPVWVVVVIAGTALASVTFFATSDSQPPRLHWL
FAFLGFLTSALWINAAATEVVNILRSLGVVFRLSNTVLGLTLLAWGNSIGDAFSDFTLAR
QGYPRMAFSACFGGIIFNILVGVGLGCLLQISRSHTEVKLEPDGLLVWVLAGALGLSLVF
SLVSVPLQCFQLSRVYGFCLLLFYLNFLVVALLTEFGVIHLKSM
GenBank ID Protein 39995086
UniProtKB/Swiss-Prot ID Q6J4K2
UniProtKB/Swiss-Prot Entry Name NCKX6_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_024959.2
GeneCard ID SLC24A6
GenAtlas ID SLC24A6
HGNC ID HGNC:26175
References
General References Not Available