Showing Protein Sodium/potassium/calcium exchanger 5 (CDBP03049)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP03049
Secondary Accession Numbers Not Available
Name Sodium/potassium/calcium exchanger 5
Description Not Available
Synonyms
  1. Na(+)/K(+)/Ca(2+)-exchange protein 5
  2. Solute carrier family 24 member 5
Gene Name SLC24A5
Protein Type Enzyme
Biological Properties
General Function Involved in transmembrane transport
Specific Function Cation exchanger involved in pigmentation, possibly by participating in ion transport in melanosomes. Probably transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+)
GO Classification
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Process
transport
transmembrane transport
establishment of localization
Cellular Location
  1. Melanosome
  2. Membrane
  3. Multi-pass membrane protein
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 15q21.1
SNPs SLC24A5
Gene Sequence 
>1503 bp
ATGCAGACAAAAGGGGGCCAAACATGGGCGAGAAGGGCTCTGTTGCTCGGCATCCTGTGG
GCCACTGCACATCTGCCTCTCTCAGGGACCTCCCTGCCCCAACGTCTCCCAAGGGCCACA
GGAAATAGCACCCAATGTGTTATTTCTCCATCATCGGAGTTTCCCGAAGGGTTTTTCACG
AGACAGGAGCGCAGAGATGGAGGCATCATAATCTATTTCCTAATTATCGTTTACATGTTC
ATGGCCATATCTATTGTCTGTGATGAATACTTCCTACCCTCCCTGGAAATCATCAGTGAA
TCCCTTGGATTGTCTCAGGATGTTGCAGGCACAACTTTCATGGCAGCGGGCAGTTCAGCT
CCTGAATTAGTTACTGCTTTCCTAGGTGTATTTATCACAAAGGGAGATATTGGCATTAGC
ACCATCCTTGGATCTGCAATTTATAATCTCCTTGGCATCTGTGCTGCCTGTGGTTTGCTA
TCTAATACGGTCTCAACACTATCATGTTGGCCCCTATTCAGAGACTGTGCAGCGTACACA
ATTAGTGCAGCAGCAGTTCTTGGTATAATATATGACAACCAAGTTTACTGGTATGAAGGG
GCTTTACTGCTTTTGATATATGGATTGTATGTTTTGGTGCTGTGTTTTGACATTAAAATT
AACCAATATATTATAAAGAAATGCAGTCCTTGCTGCGCCTGTCTTGCCAAAGCTATGGAG
AGAAGTGAACAACAGCCACTGATGGGCTGGGAAGATGAAGGTCAACCATTCATTCGTCGG
CAATCAAGAACTGATAGTGGAATATTTTATGAAGATTCTGGCTACTCTCAGCTCTCTATA
AGTTTACATGGCCTTAGTCAGGTTTCTGAAGATCCACCAAGTGTTTTCAACATGCCTGAA
GCAGACTTAAAAAGAATTTTTTGGGTATTATCCCTTCCTATTATTACATTACTTTTTCTA
ACCACACCAGATTGTAGAAAAAAGTTTTGGAAAAACTACTTTGTGATAACCTTTTTCATG
TCTGCAATATGGATATCCGCATTTACATATATCCTGGTTTGGATGGTCACAATTACAGGG
GAAACACTAGAAATTCCCGATACAGTAATGGGCCTTACTTTATTAGCAGCAGGAACAAGC
ATACCAGACACAATTGCAAGTGTGTTGGTTGCAAGAAAAGGGAAAGGAGATATGGCTATG
TCTAACATCGTGGGATCCAATGTGTTTGATATGTTGTGCCTTGGTATTCCATGGTTTATT
AAAACTGCATTTATAAATGGATCAGCTCCTGCAGAAGTAAACAGCAGAGGACTAACTTAC
ATAACCATCTCTCTCAACATTTCAATTATTTTTCTTTTTTTAGCAGTTCACTTCAATGGC
TGGAAACTAGACAGAAAGTTGGGAATAGTCTGCCTATTATCATACTTGGGGCTTGCTACA
TTATCAGTTCTATATGAACTTGGAATTATTGGAAATAATAAAATAAGGGGCTGTGGAGGT
TGA
Protein Properties
Number of Residues 500
Molecular Weight 54887.6
Theoretical pI 5.83
Pfam Domain Function
Signals
  • ["1-29"]
Transmembrane Regions
  • ["67-87", "112-132", "137-157", "170-190", "196-216", "303-323", "334-354", "369-389", "400-420", "438-458", "469-489"]
Protein Sequence 
>Sodium/potassium/calcium exchanger 5
MQTKGGQTWARRALLLGILWATAHLPLSGTSLPQRLPRATGNSTQCVISPSSEFPEGFFT
RQERRDGGIIIYFLIIVYMFMAISIVCDEYFLPSLEIISESLGLSQDVAGTTFMAAGSSA
PELVTAFLGVFITKGDIGISTILGSAIYNLLGICAACGLLSNTVSTLSCWPLFRDCAAYT
ISAAAVLGIIYDNQVYWYEGALLLLIYGLYVLVLCFDIKINQYIIKKCSPCCACLAKAME
RSEQQPLMGWEDEGQPFIRRQSRTDSGIFYEDSGYSQLSISLHGLSQVSEDPPSVFNMPE
ADLKRIFWVLSLPIITLLFLTTPDCRKKFWKNYFVITFFMSAIWISAFTYILVWMVTITG
ETLEIPDTVMGLTLLAAGTSIPDTIASVLVARKGKGDMAMSNIVGSNVFDMLCLGIPWFI
KTAFINGSAPAEVNSRGLTYITISLNISIIFLFLAVHFNGWKLDRKLGIVCLLSYLGLAT
LSVLYELGIIGNNKIRGCGG
GenBank ID Protein 33341100
UniProtKB/Swiss-Prot ID Q71RS6
UniProtKB/Swiss-Prot Entry Name NCKX5_HUMAN
PDB IDs Not Available
GenBank Gene ID AF348468
GeneCard ID SLC24A5
GenAtlas ID SLC24A5
HGNC ID HGNC:20611
References
General References Not Available