| Identification |
|---|
| HMDB Protein ID
| CDBP03047 |
| Secondary Accession Numbers
| Not Available |
| Name
| Sodium leak channel non-selective protein |
| Description
| Not Available |
| Synonyms
|
- CanIon
- Voltage gated channel-like protein 1
|
| Gene Name
| NALCN |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in ion channel activity |
| Specific Function
| Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Responsible for the background sodium ion leak current in neurons and controls neuronal excitability. Activated either by neuropeptides substance P or neurotensin. Required for normal respiratory rhythm and neonatal survival |
| GO Classification
|
| Component |
| membrane |
| cell part |
| Function |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| ion transmembrane transporter activity |
| transporter activity |
| ion channel activity |
| Process |
| establishment of localization |
| transport |
| transmembrane transport |
| ion transport |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein (Potential)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 13q32.3 |
| SNPs
| NALCN |
| Gene Sequence
|
>5217 bp
ATGCTCAAAAGGAAGCAGAGTTCCAGGGTGGAAGCCCAGCCAGTCACTGACTTTGGTCCT
GATGAGTCTCTGTCGGATAATGCTGACATCCTCTGGATTAACAAACCATGGGTTCACTCT
TTGCTGCGCATCTGTGCCATCATCAGCGTCATTTCTGTTTGTATGAATACGCCAATGACC
TTCGAGCACTATCCTCCACTTCAGTATGTGACCTTCACTTTGGATACATTATTGATGTTT
CTCTACACGGCAGAGATGATAGCAAAAATGCACATCCGGGGCATTGTCAAGGGGGATAGT
TCCTATGTGAAAGATCGCTGGTGTGTTTTTGATGGATTTATGGTCTTTTGCCTTTGGGTT
TCTTTGGTGCTACAGGTGTTTGAAATTGCTGATATAGTTGATCAGATGTCACCTTGGGGC
ATGTTGCGGATTCCACGGCCACTGATTATGATCCGAGCATTCCGGATTTATTTCCGATTT
GAACTGCCAAGGACCAGAATTACAAATATTTTAAAGCGATCGGGAGAACAAATATGGAGT
GTTTCCATTTTTCTACTTTTCTTTCTACTTCTTTATGGAATTTTAGGAGTTCAGATGTTT
GGAACATTTACTTATCACTGTGTTGTAAATGACACAAAGCCAGGGAATGTAACCTGGAAT
AGTTTAGCTATTCCAGACACACACTGCTCACCAGAGCTAGAAGAAGGCTACCAGTGCCCA
CCTGGATTTAAATGCATGGACCTTGAAGATCTGGGACTTAGCAGGCAAGAGCTGGGCTAC
AGTGGCTTTAATGAGATAGGAACTAGTATATTCACCGTCTATGAGGCCGCCTCACAGGAA
GGCTGGGTGTTCCTCATGTACAGAGCAATTGACAGCTTTCCCCGTTGGCGTTCCTACTTC
TATTTCATCACTCTCATTTTCTTCCTCGCCTGGCTTGTGAAGAACGTGTTTATTGCTGTT
ATCATTGAAACATTTGCAGAAATCAGAGTACAGTTTCAACAAATGTGGGGATCGAGAAGC
AGCACTACCTCAACAGCCACCACCCAGATGTTTCATGAAGATGCTGCTGGAGGTTGGCAG
CTGGTAGCTGTGGATGTCAACAAGCCCCAGGGACGCGCCCCAGCCTGCCTCCAGAAAATG
ATGCGGTCATCCGTTTTCCACATGTTCATCCTGAGCATGGTGACCGTGGACGTGATCGTG
GCGGCTAGCAACTACTACAAAGGAGAAAACTTCAGGAGGCAGTACGACGAGTTCTACCTG
GCGGAGGTGGCTTTTACAGTACTTTTTGATTTGGAAGCACTTCTGAAGATATGGTGTTTG
GGATTTACTGGATATATTAGCTCATCTCTCCACAAATTCGAACTACTACTCGTAATTGGA
ACTACTCTTCATGTATACCCAGATCTTTATCATTCACAATTCACGTACTTTCAGGTTCTC
CGAGTAGTTCGGCTGATTAAGATTTCACCTGCATTAGAAGACTTTGTGTACAAGATATTT
GGTCCTGGAAAAAAGCTTGGGAGTTTGGTTGTATTTACTGCCAGCCTCTTGATTGTTATG
TCAGCAATTAGTTTGCAGATGTTCTGCTTTGTCGAAGAACTGGACAGATTTACTACGTTT
CCGAGGGCATTTATGTCCATGTTCCAGATCCTCACCCAGGAAGGATGGGTGGACGTAATG
GACCAAACTCTAAATGCTGTGGGACATATGTGGGCACCCGTGGTTGCCATCTATTTCATT
CTCTATCATCTTTTTGCCACTCTGATCCTCCTGAGTTTGTTTGTTGCTGTTATTTTGGAC
AACTTAGAACTTGATGAAGACCTAAAGAAGCTTAAACAATTAAAGCAAAGTGAAGCAAAT
GCGGACACCAAAGAAAAGCTCCCTTTACGCCTGCGAATCTTTGAAAAATTTCCAAACAGA
CCTCAAATGGTGAAAATCTCAAAGCTTCCTTCAGATTTTACAGTTCCTAAAATCAGGGAG
AGTTTTATGAAGCAGTTTATTGACCGCCAGCAACAGGACACATGTTGCCTCCTGAGAAGC
CTCCCGACCACCTCTTCCTCCTCCTGCGACCACTCCAAACGCTCAGCAATTGAGGACAAC
AAATACATCGACCAAAAACTTCGCAAGTCTGTTTTCAGCATCAGGGCAAGGAACCTTCTG
GAAAAGGAGACCGCAGTCACTAAAATCTTAAGAGCTTGCACCCGACAGCGCATGCTGAGC
GGATCATTTGAGGGGCAGCCCGCAAAGGAGAGGTCAATCCTCAGCGTGCAGCATCATATC
CGCCAAGAGCGCAGGTCACTAAGACATGGATCAAACAGCCAGAGGATCAGCAGGGGAAAA
TCTCTTGAAACTTTGACTCAAGATCATTCCAATACAGTGAGATATAGAAATGCACAAAGA
GAAGACAGTGAAATAAAGATGATTCAGGAAAAAAAGGAGCAAGCAGAGATGAAAAGGAAA
GTGCAAGAAGAGGAACTCAGAGAGAACCACCCATACTTCGATAAGCCACTGTTCATTGTC
GGGCGAGAACACAGGTTCAGAAACTTTTGCCGGGTGGTGGTCCGAGCACGCTTCAACGCA
TCTAAAACAGACCCTGTCACAGGAGCTGTGAAAAATACAAAGTACCATCAACTTTATGAT
TTGCTGGGATTGGTCACTTACCTGGACTGGGTCATGATCATCGTAACCATCTGCTCTTGC
ATTTCCATGATGTTTGAGTCCCCGTTTCGAAGAGTCATGCATGCACCTACTTTGCAGATT
GCTGAGTATGTGTTTGTGATATTCATGAGCATTGAGCTTAATCTGAAGATTATGGCAGAT
GGCTTATTTTTCACTCCAACTGCTGTCATCAGGGACTTCGGTGGAGTAATGGACATATTT
ATATATCTTGTGAGCTTGATATTTCTTTGTTGGATGCCTCAAAATGTACCTGCTGAATCG
GGAGCTCAGCTTCTAATGGTCCTTCGGTGCCTGAGACCTCTGCGCATATTCAAACTGGTG
CCCCAGATGAGGAAAGTTGTTCGAGAACTTTTCAGCGGCTTCAAGGAAATTTTTTTGGTC
TCCATTCTTTTGCTGACATTAATGCTCGTTTTTGCAAGCTTTGGAGTTCAGCTTTTTGCT
GGAAAACTGGCCAAGTGCAATGATCCCAACATTATTAGAAGGGAAGATTGCAATGGCATA
TTCAGAATTAATGTCAGTGTGTCAAAGAACTTAAATTTAAAATTGAGGCCTGGAGAGAAA
AAACCTGGATTTTGGGTGCCCCGTGTTTGGGCGAATCCTCGGAACTTTAATTTCGACAAT
GTGGGAAACGCTATGCTGGCGTTGTTTGAAGTTCTCTCCTTGAAAGGCTGGGTGGAAGTG
AGAGATGTTATTATTCATCGTGTGGGGCCGATCCATGGAATCTATATTCATGTTTTTGTA
TTCCTGGGTTGCATGATTGGACTGACCCTTTTTGTTGGAGTAGTTATTGCTAATTTCAAT
GAAAACAAGGGGACGGCTTTGCTGACCGTCGATCAGAGAAGATGGGAAGACCTGAAGAGC
CGACTGAAGATCGCACAGCCTCTTCATCTTCCGCCTCGCCCGGATAATGATGGTTTTAGA
GCTAAAATGTATGACATAACCCAGCATCCATTTTTTAAGAGGACAATCGCATTACTCGTC
CTGGCCCAGTCGGTGTTGCTCTCTGTCAAGTGGGACGTCGAGGACCCGGTGACCGTACCT
TTGGCAACAATGTCAGTTGTTTTCACCTTCATCTTTGTTCTGGAGGTTACCATGAAGATC
ATAGCAATGTCGCCTGCTGGCTTCTGGCAAAGCAGAAGAAACCGATACGATCTCCTGGTG
ACGTCGCTTGGCGTTGTATGGGTGGTGCTTCACTTTGCCCTCCTGAATGCATATACTTAC
ATGATGGGCGCTTGTGTGATTGTATTTAGGTTTTTCTCCATCTGTGGAAAACATGTAACG
CTAAAGATGCTCCTCTTGACAGTGGTCGTCAGCATGTACAAGAGCTTCTTTATCATAGTA
GGCATGTTTCTCTTGCTGCTGTGTTACGCTTTTGCTGGAGTTGTTTTATTTGGTACTGTG
AAATATGGGGAGAATATTAACAGGCATGCAAATTTTTCTTCGGCTGGAAAAGCTATTACC
GTACTGTTCCGAATTGTCACAGGTGAAGACTGGAACAAGATTATGCATGACTGTATGGTT
CAGCCTCCGTTTTGTACTCCAGATGAATTTACATACTGGGCAACAGACTGTGGAAATTAT
GCTGGGGCACTTATGTATTTCTGTTCATTTTATGTCATCATTGCCTACATCATGCTAAAT
CTGCTTGTAGCCATAATTGTGGAGAATTTCTCCTTGTTTTATTCCACTGAGGAGGACCAG
CTTTTAAGTTACAATGATCTTCGCCACTTTCAAATAATATGGAACATGGTGGATGATAAA
AGAGAGGGGGTGATCCCCACGTTCCGCGTCAAGTTCCTGCTGCGGCTACTGCGTGGGAGG
CTGGAGGTGGACCTGGACAAGGACAAGCTCCTGTTTAAGCACATGTGCTACGAAATGGAG
AGGCTCCACAATGGCGGCGACGTCACCTTCCATGATGTCCTGAGCATGCTTTCATACCGG
TCCGTGGACATCCGGAAGAGCTTGCAGCTGGAGGAACTCCTGGCGAGGGAGCAGCTGGAG
TACACCATAGAGGAGGAGGTGGCCAAGCAGACCATCCGCATGTGGCTCAAGAAGTGCCTG
AAGCGCATCAGAGCTAAACAGCAGCAGTCGTGCAGTATCATCCACAGCCTGAGAGAGAGT
CAGCAGCAAGAGCTGAGCCGGTTTCTGAACCCGCCCAGCATCGAGACCACCCAGCCCAGT
GAGGACACGAATGCCAACAGTCAGGACAACAGCATGCAACCTGAGACAAGCAGCCAGCAG
CAGCTCCTGAGCCCCACGCTGTCGGATCGAGGAGGAAGTCGGCAAGATGCAGCCGACGCA
GGGAAACCCCAGAGGAAATTTGGGCAGTGGCGTCTGCCCTCAGCCCCAAAACCAATAAGC
CATTCAGTGTCCTCAGTCAACTTACGGTTTGGAGGAAGGACAACCATGAAATCTGTCGTG
TGCAAAATGAACCCCATGACTGACGCGGCTTCCTGCGGTTCTGAAGTTAAGAAGTGGTGG
ACCCGGCAGCTGACTGTGGAGAGCGACGAAAGTGGGGATGACCTTCTGGATATTTAG
|
| Protein Properties |
|---|
| Number of Residues
| 1738 |
| Molecular Weight
| 200329.6 |
| Theoretical pI
| 8.84 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["41-61", "67-87", "107-127", "139-158", "183-203", "302-322", "383-403", "423-443", "449-468", "477-500", "510-530", "579-599", "881-901", "924-944", "953-973", "980-997", "1016-1036", "1136-1156", "1210-1227", "1236-1256", "1278-1298", "1300-1316", "1336-1356", "1427-1447"]
|
| Protein Sequence
|
>Sodium leak channel non-selective protein
MLKRKQSSRVEAQPVTDFGPDESLSDNADILWINKPWVHSLLRICAIISVISVCMNTPMT
FEHYPPLQYVTFTLDTLLMFLYTAEMIAKMHIRGIVKGDSSYVKDRWCVFDGFMVFCLWV
SLVLQVFEIADIVDQMSPWGMLRIPRPLIMIRAFRIYFRFELPRTRITNILKRSGEQIWS
VSIFLLFFLLLYGILGVQMFGTFTYHCVVNDTKPGNVTWNSLAIPDTHCSPELEEGYQCP
PGFKCMDLEDLGLSRQELGYSGFNEIGTSIFTVYEAASQEGWVFLMYRAIDSFPRWRSYF
YFITLIFFLAWLVKNVFIAVIIETFAEIRVQFQQMWGSRSSTTSTATTQMFHEDAAGGWQ
LVAVDVNKPQGRAPACLQKMMRSSVFHMFILSMVTVDVIVAASNYYKGENFRRQYDEFYL
AEVAFTVLFDLEALLKIWCLGFTGYISSSLHKFELLLVIGTTLHVYPDLYHSQFTYFQVL
RVVRLIKISPALEDFVYKIFGPGKKLGSLVVFTASLLIVMSAISLQMFCFVEELDRFTTF
PRAFMSMFQILTQEGWVDVMDQTLNAVGHMWAPVVAIYFILYHLFATLILLSLFVAVILD
NLELDEDLKKLKQLKQSEANADTKEKLPLRLRIFEKFPNRPQMVKISKLPSDFTVPKIRE
SFMKQFIDRQQQDTCCLLRSLPTTSSSSCDHSKRSAIEDNKYIDQKLRKSVFSIRARNLL
EKETAVTKILRACTRQRMLSGSFEGQPAKERSILSVQHHIRQERRSLRHGSNSQRISRGK
SLETLTQDHSNTVRYRNAQREDSEIKMIQEKKEQAEMKRKVQEEELRENHPYFDKPLFIV
GREHRFRNFCRVVVRARFNASKTDPVTGAVKNTKYHQLYDLLGLVTYLDWVMIIVTICSC
ISMMFESPFRRVMHAPTLQIAEYVFVIFMSIELNLKIMADGLFFTPTAVIRDFGGVMDIF
IYLVSLIFLCWMPQNVPAESGAQLLMVLRCLRPLRIFKLVPQMRKVVRELFSGFKEIFLV
SILLLTLMLVFASFGVQLFAGKLAKCNDPNIIRREDCNGIFRINVSVSKNLNLKLRPGEK
KPGFWVPRVWANPRNFNFDNVGNAMLALFEVLSLKGWVEVRDVIIHRVGPIHGIYIHVFV
FLGCMIGLTLFVGVVIANFNENKGTALLTVDQRRWEDLKSRLKIAQPLHLPPRPDNDGFR
AKMYDITQHPFFKRTIALLVLAQSVLLSVKWDVEDPVTVPLATMSVVFTFIFVLEVTMKI
IAMSPAGFWQSRRNRYDLLVTSLGVVWVVLHFALLNAYTYMMGACVIVFRFFSICGKHVT
LKMLLLTVVVSMYKSFFIIVGMFLLLLCYAFAGVVLFGTVKYGENINRHANFSSAGKAIT
VLFRIVTGEDWNKIMHDCMVQPPFCTPDEFTYWATDCGNYAGALMYFCSFYVIIAYIMLN
LLVAIIVENFSLFYSTEEDQLLSYNDLRHFQIIWNMVDDKREGVIPTFRVKFLLRLLRGR
LEVDLDKDKLLFKHMCYEMERLHNGGDVTFHDVLSMLSYRSVDIRKSLQLEELLAREQLE
YTIEEEVAKQTIRMWLKKCLKRIRAKQQQSCSIIHSLRESQQQELSRFLNPPSIETTQPS
EDTNANSQDNSMQPETSSQQQLLSPTLSDRGGSRQDAADAGKPQRKFGQWRLPSAPKPIS
HSVSSVNLRFGGRTTMKSVVCKMNPMTDAASCGSEVKKWWTRQLTVESDESGDDLLDI
|
| External Links |
|---|
| GenBank ID Protein
| 24119274 |
| UniProtKB/Swiss-Prot ID
| Q8IZF0 |
| UniProtKB/Swiss-Prot Entry Name
| NALCN_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_052867.2 |
| GeneCard ID
| NALCN |
| GenAtlas ID
| NALCN |
| HGNC ID
| HGNC:19082 |
| References |
|---|
| General References
| Not Available |