| Identification |
|---|
| HMDB Protein ID
| CDBP03030 |
| Secondary Accession Numbers
| Not Available |
| Name
| Mas-related G-protein coupled receptor member X1 |
| Description
| Not Available |
| Synonyms
|
- Sensory neuron-specific G-protein coupled receptor 3/4
|
| Gene Name
| MRGPRX1 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in G-protein coupled receptor protein signaling pathway |
| Specific Function
| Orphan receptor. Probably involved in the function of nociceptive neurons. May regulate nociceptor function and/or development, including the sensation or modulation of pain. Potently activated by enkephalins including BAM22 (bovine adrenal medulla peptide 22) and BAM (8-22). BAM22 is the most potent compound and evoked a large and dose-dependent release of intracellular calcium in stably transfected cells. G(alpha)q proteins are involved in the calcium-signaling pathway. Activated by the antimalarial drug, chloroquine. May mediate chloroquine- induced itch, in an histamine-independent manner |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Process |
| signaling |
| signaling pathway |
| cell surface receptor linked signaling pathway |
| g-protein coupled receptor protein signaling pathway |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 11p15.1|11 |
| SNPs
| MRGPRX1 |
| Gene Sequence
|
>969 bp
ATGGATCCAACCATCTCAACCTTGGACACAGAACTGACACCAATCAACGGAACTGAGGAG
ACTCTTTGCTACAAGCAGACCTTGAGCCTCACGGTGCTGACGTGCATCGTTTCCCTTGTC
GGGCTGACAGGAAACGCAGTTGTGCTCTGGCTCCTGGGCTGCCGCATGCGCAGGAACGCC
TTCTCCATCTACATCCTCAACTTGGCCGCAGCAGACTTCCTCTTCCTCAGCGGCCGCCTT
ATATATTCCCTGTTAAGCTTCATCAGTATCCCCCATACCATCTCTAAAATCCTCTATCCT
GTGATGATGTTTTCCTACTTTGCAGGCCTGAGCTTTCTGAGTGCCGTGAGCACCGAGCGC
TGCCTGTCCGTCCTGTGGCCCATCTGGTACCGCTGCCACCGCCCCACACACCTGTCAGCG
GTGGTGTGTGTCCTGCTCTGGGCCCTGTCCCTGCTGCGGAGCATCCTGGAGTGGATGTTA
TGTGGCTTCCTGTTCAGTGGTGCTGATTCTGCTTGGTGTCAAACATCAGATTTCATCACA
GTCGCGTGGCTGATTTTTTTATGTGTGGTTCTCTGTGGGTCCAGCCTGGTCCTGCTGATC
AGGATTCTCTGTGGATCCCGGAAGATACCGCTGACCAGGCTGTACGTGACCATCCTGCTC
ACAGTACTGGTCTTCCTCCTCTGTGGCCTGCCCTTTGGCATTCAGTTTTTCCTATTTTTA
TGGATCCACGTGGACAGGGAAGTCTTATTTTGTCATGTTCATCTAGTTTCTATTTTCCTG
TCCGCTCTTAACAGCAGTGCCAACCCCATCATTTACTTCTTCGTGGGCTCCTTTAGGCAG
CGTCAAAATAGGCAGAACCTGAAGCTGGTTCTCCAGAGGGCTCTGCAGGACGCGTCTGAG
GTGGATGAAGGTGGAGGGCAGCTTCCTGAGGAAATCCTGGAGCTGTCGGGAAGCAGATTG
GAGCAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 322 |
| Molecular Weight
| 36249.6 |
| Theoretical pI
| 7.57 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["32-52", "68-88", "97-117", "145-165", "178-198", "222-242", "255-275"]
|
| Protein Sequence
|
>Mas-related G-protein coupled receptor member X1
MDPTISTLDTELTPINGTEETLCYKQTLSLTVLTCIVSLVGLTGNAVVLWLLGCRMRRNA
FSIYILNLAAADFLFLSGRLIYSLLSFISIPHTISKILYPVMMFSYFAGLSFLSAVSTER
CLSVLWPIWYRCHRPTHLSAVVCVLLWALSLLRSILEWMLCGFLFSGADSAWCQTSDFIT
VAWLIFLCVVLCGSSLVLLIRILCGSRKIPLTRLYVTILLTVLVFLLCGLPFGIQFFLFL
WIHVDREVLFCHVHLVSIFLSALNSSANPIIYFFVGSFRQRQNRQNLKLVLQRALQDASE
VDEGGGQLPEEILELSGSRLEQ
|
| External Links |
|---|
| GenBank ID Protein
| 21928957 |
| UniProtKB/Swiss-Prot ID
| Q96LB2 |
| UniProtKB/Swiss-Prot Entry Name
| MRGX1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB065846 |
| GeneCard ID
| MRGPRX1 |
| GenAtlas ID
| MRGPRX1 |
| HGNC ID
| HGNC:17962 |
| References |
|---|
| General References
| Not Available |