| Identification |
|---|
| HMDB Protein ID
| CDBP03029 |
| Secondary Accession Numbers
| Not Available |
| Name
| C-type mannose receptor 2 |
| Description
| Not Available |
| Synonyms
|
- C-type lectin domain family 13 member E
- CD280 antigen
- Endocytic receptor 180
- Macrophage mannose receptor 2
- UPAR-associated protein
- Urokinase receptor-associated protein
- Urokinase-type plasminogen activator receptor-associated protein
|
| Gene Name
| MRC2 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in sugar binding |
| Specific Function
| May play a role as endocytotic lectin receptor displaying calcium-dependent lectin activity. Internalizes glycosylated ligands from the extracellular space for release in an endosomal compartment via clathrin-mediated endocytosis. May be involved in plasminogen activation system controlling the extracellular level of PLAUR/PLAU, and thus may regulate protease activity at the cell surface. May contribute to cellular uptake, remodeling and degradation of extracellular collagen matrices. May play a role during cancer progression as well as in other chronic tissue destructive diseases acting on collagen turnover. May participate in remodeling of extracellular matrix co-operating with the matrix metalloproteinases (MMPs) |
| GO Classification
|
| Function |
| binding |
| carbohydrate binding |
| sugar binding |
|
| Cellular Location
|
- Membrane
- Single-pass type I membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 17q23.2 |
| SNPs
| MRC2 |
| Gene Sequence
|
>4440 bp
ATGGGGCCCGGCCGGCCGGCCCCCGCGCCCTGGCCTCGTCACCTGCTGCGCTGCGTCCTG
CTCCTCGGGTGCCTGCACCTCGGCCGTCCCGGCGCCCCTGGGGACGCCGCCCTCCCGGAA
CCCAACGTCTTCCTCATCTTCAGCCATGGACTGCAGGGCTGCCTGGAGGCCCAGGGCGGG
CAGGTCAGAGTCACCCCGGCTTGCAATACCAGCCTCCCTGCCCAGCGCTGGAAGTGGGTC
TCCCGAAACCGGCTATTCAACCTGGGTACCATGCAGTGCCTGGGCACAGGCTGGCCAGGC
ACCAACACCACGGCCTCCCTGGGCATGTATGAGTGTGACCGGGAAGCACTGAATCTTCGC
TGGCATTGTCGTACACTGGGTGACCAGCTGTCCTTGCTCCTGGGGGCCCGCACCAGCAAC
ATATCCAAGCCTGGCACCCTTGAGCGTGGTGACCAGACCCGCAGTGGCCAGTGGCGCATC
TACGGCAGCGAGGAGGACCTATGTGCTCTGCCCTACCACGAGGTCTACACCATCCAGGGA
AACTCCCACGGAAAGCCGTGCACCATCCCCTTCAAATATGACAACCAGTGGTTCCACGGC
TGCACCAGCACGGGCCGCGAGGATGGTCACCTGTGGTGTGCCACCACCCAGGACTACGGC
AAAGACGAGCGCTGGGGCTTCTGCCCCATCAAGAGTAACGACTGCGAGACCTTCTGGGAC
AAGGACCAGCTGACTGACAGCTGCTACCAGTTTAACTTCCAGTCCACGCTGTCGTGGAGG
GAGGCCTGGGCCAGCTGCGAGCAGCAGGGTGCGGATCTGCTGAGCATCACGGAGATCCAC
GAGCAGACCTACATCAACGGCCTCCTCACTGGGTACAGCTCCACCCTGTGGATCGGCTTG
AATGACTTGGACACGAGCGGAGGCTGGCAGTGGTCGGACAACTCGCCCCTCAAGTACCTC
AACTGGGAGAGTGACCAGCCGGACAACCCCAGTGAGGAGAACTGTGGAGTGATCCGCACT
GAGTCCTCGGGCGGCTGGCAGAACCGTGACTGCAGCATCGCGCTGCCCTATGTGTGCAAG
AAGAAGCCCAACGCCACGGCCGAGCCCACCCCTCCAGACAGGTGGGCCAATGTGAAGGTG
GAGTGCGAGCCGAGCTGGCAGCCCTTCCAGGGCCACTGCTACCGCCTGCAGGCCGAGAAG
CGCAGCTGGCAGGAGTCCAAGAAGGCATGTCTACGGGGCGGTGGCGACCTGGTCAGCATC
CACAGCATGGCGGAGCTGGAATTCATCACCAAGCAGATCAAGCAAGAGGTGGAGGAGCTG
TGGATCGGCCTCAACGATTTGAAACTGCAGATGAATTTTGAGTGGTCTGACGGGAGCCTT
GTGAGCTTCACCCACTGGCACCCCTTTGAGCCCAACAACTTCCGGGACAGTCTGGAGGAC
TGTGTCACCATCTGGGGCCCGGAAGGCCGCTGGAACGACAGTCCCTGTAACCAGTCCTTG
CCATCCATCTGCAAGAAGGCAGGCCAGCTGAGCCAGGGGGCCGCCGAGGAGGACCATGGC
TGCCGGAAGGGTTGGACGTGGCACAGCCCATCCTGCTACTGGCTGGGAGAAGACCAAGTG
ACCTACAGTGAGGCCCGGCGCCTGTGCACTGACCATGGCTCTCAGCTGGTCACCATCACC
AACAGGTTCGAGCAGGCCTTCGTCAGCAGCCTCATCTACAACTGGGAGGGCGAGTACTTC
TGGACGGCCCTGCAGGACCTCAACAGCACCGGCTCCTTCTTCTGGCTCAGTGGGGATGAA
GTCATGTACACCCACTGGAACCGGGACCAGCCCGGGTACAGCCGTGGGGGCTGCGTGGCG
CTGGCCACTGGCAGCGCCATGGGGCTGTGGGAGGTGAAGAACTGTACCTCGTTCCGGGCC
CGCTACATCTGCCGGCAGAGCCTGGGCACTCCAGTGACGCCGGAGCTGCCGGGGCCAGAT
CCCACGCCCAGCCTCACTGGCTCCTGTCCCCAGGGCTGGGCCTCGGACACCAAACTCCGG
TATTGCTATAAGGTGTTCAGCTCAGAGCGGCTGCAGGACAAGAAGAGCTGGGTCCAGGCC
CAGGGGGCCTGCCAGGAGCTGGGGGCCCAGCTGCTGAGCCTGGCCAGCTACGAGGAGGAG
CACTTTGTGGCCAACATGCTCAACAAGATCTTCGGTGAATCAGAACCCGAGATCCACGAG
CAGCACTGGTTCTGGATCGGCCTGAACCGTCGGGATCCCAGAGGGGGTCAGAGTTGGCGC
TGGAGCGACGGCGTAGGGTTCTCTTACCACAATTTCGACCGGAGCCGGCACGACGACGAC
GACATCCGAGGCTGTGCGGTGCTGGACCTGGCCTCCCTGCAGTGGGTGGCCATGCAGTGC
GACACACAGCTGGACTGGATCTGCAAGATCCCCAGAGGTACGGACGTGCGGGAGCCCGAC
GACAGCCCTCAAGGCCGACGGGAATGGCTGCGCTTCCAGGAGGCCGAGTACAAGTTCTTT
GAGCACCACTCCACGTGGGCGCAGGCGCAGCGCATCTGCACGTGGTTCCAGGCCGAGCTG
ACCTCGGTGCACAGCCAGGCGGAGCTAGACTTCCTGAGCCACAACTTGCAGAAGTTCTCC
CGGGCCCAGGAGCAGCACTGGTGGATCGGCCTGCACACCTCTGAGAGCGATGGGCGCTTC
AGATGGACAGATGGTTCCATTATAAACTTCATCTCCTGGGCACCAGGCAAACCTCGGCCT
GTCGGCAAGGACAAGAAGTGCGTGTACATGACAGCCAGCCGAGAGGACTGGGGGGACCAG
AGGTGCCTGACAGCCTTGCCCTACATCTGCAAGCGCAGCAACGTCACCAAAGAAACGCAG
CCCCCAGACCTGCCAACTACAGCCCTGGGGGGCTGCCCCTCTGACTGGATCCAGTTCCTC
AACAAGTGTTTTCAGGTCCAGGGCCAGGAACCCCAGAGCCGGGTGAAGTGGTCAGAGGCA
CAGTTCTCCTGTGAACAGCAAGAGGCCCAGCTGGTCACCATCACAAACCCCTTAGAGCAA
GCATTCATCACAGCCAGCCTGCCCAATGTGACCTTTGACCTTTGGATTGGCCTCCATGCC
TCGCAGAGGGACTTCCAGTGGGTGGAGCAGGAGCCTTTGATGTATGCCAACTGGGCACCT
GGGGAGCCCTCTGGCCCTAGCCCTGCTCCCAGTGGCAACAAACCGACCAGCTGTGCAGTG
GTCCTGCACAGCCCCTCAGCCCACTTCACTGGCCGCTGGGACGATCGGAGCTGCACGGAG
GAGACCCATGGCTTCATCTGCCAGAAGGGCACGGACCCCTCCCTGAGCCCGTCCCCAGCA
GCGCTGCCCCCCGCCCCGGGCACTGAGCTCTCCTACCTCAACGGCACCTTCCGGCTGCTT
CAGAAGCCGCTGCGCTGGCACGATGCCCTCCTGCTGTGTGAGAGCCGCAATGCCAGCCTG
GCCTACGTGCCCGACCCCTACACCCAGGCCTTCCTCACGCAGGCTGCCCGAGGGCTGCGC
ACGCCGCTCTGGATTGGGCTGGCTGGCGAGGAGGGCTCTCGGCGGTACTCCTGGGTCTCA
GAGGAGCCGCTGAACTACGTGGGCTGGCAGGACGGGGAGCCGCAGCAGCCGGGGGGCTGT
ACCTACGTAGATGTGGACGGGGCCTGGCGCACCACCAGCTGTGACACCAAGCTGCAGGGG
GCTGTGTGTGGGGTTAGCAGTGGGCCCCCTCCTCCCCGAAGAATAAGCTACCATGGCAGC
TGTCCCCAGGGACTGGCAGACTCCGCGTGGATTCCCTTCCGGGAGCACTGCTATTCTTTC
CACATGGAGCTGCTGCTGGGCCACAAGGAGGCGCGACAGCGCTGCCAGAGAGCGGGTGGG
GCCGTCCTGTCTATCCTGGATGAGATGGAGAATGTGTTTGTCTGGGAGCACCTGCAGAGC
TATGAGGGCCAGAGTCGGGGCGCCTGGCTGGGCATGAACTTCAACCCCAAAGGAGGCACT
CTGGTCTGGCAGGACAACACAGCTGTGAACTACTCCAACTGGGGGCCCCCGGGCTTGGGC
CCCAGCATGCTGAGCCACAACAGCTGCTACTGGATTCAGAGCAACAGCGGGCTATGGCGC
CCCGGCGCTTGCACCAACATCACCATGGGTGTCGTCTGCAAGCTTCCTCGTGCTGAGCAG
AGCAGCTTCTCCCCATCAGCGCTTCCAGAGAACCCAGCGGCCCTGGTGGTGGTGCTGATG
GCGGTGCTGCTGCTCCTGGCCTTGCTGACCGCAGCCCTCATCCTTTACCGGAGGCGCCAG
AGCATCGAGCGCGGGGCCTTTGAGGGTGCCCGCTACAGCCGCAGCAGCTCCAGCCCCACC
GAGGCCACTGAGAAGAACATCCTGGTGTCAGACATGGAAATGAATGAGCAACAAGAATAG
|
| Protein Properties |
|---|
| Number of Residues
| 1479 |
| Molecular Weight
| 166654.2 |
| Theoretical pI
| 5.64 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>C-type mannose receptor 2
MGPGRPAPAPWPRHLLRCVLLLGCLHLGRPGAPGDAALPEPNVFLIFSHGLQGCLEAQGG
QVRVTPACNTSLPAQRWKWVSRNRLFNLGTMQCLGTGWPGTNTTASLGMYECDREALNLR
WHCRTLGDQLSLLLGARTSNISKPGTLERGDQTRSGQWRIYGSEEDLCALPYHEVYTIQG
NSHGKPCTIPFKYDNQWFHGCTSTGREDGHLWCATTQDYGKDERWGFCPIKSNDCETFWD
KDQLTDSCYQFNFQSTLSWREAWASCEQQGADLLSITEIHEQTYINGLLTGYSSTLWIGL
NDLDTSGGWQWSDNSPLKYLNWESDQPDNPSEENCGVIRTESSGGWQNRDCSIALPYVCK
KKPNATAEPTPPDRWANVKVECEPSWQPFQGHCYRLQAEKRSWQESKKACLRGGGDLVSI
HSMAELEFITKQIKQEVEELWIGLNDLKLQMNFEWSDGSLVSFTHWHPFEPNNFRDSLED
CVTIWGPEGRWNDSPCNQSLPSICKKAGQLSQGAAEEDHGCRKGWTWHSPSCYWLGEDQV
TYSEARRLCTDHGSQLVTITNRFEQAFVSSLIYNWEGEYFWTALQDLNSTGSFFWLSGDE
VMYTHWNRDQPGYSRGGCVALATGSAMGLWEVKNCTSFRARYICRQSLGTPVTPELPGPD
PTPSLTGSCPQGWASDTKLRYCYKVFSSERLQDKKSWVQAQGACQELGAQLLSLASYEEE
HFVANMLNKIFGESEPEIHEQHWFWIGLNRRDPRGGQSWRWSDGVGFSYHNFDRSRHDDD
DIRGCAVLDLASLQWVAMQCDTQLDWICKIPRGTDVREPDDSPQGRREWLRFQEAEYKFF
EHHSTWAQAQRICTWFQAELTSVHSQAELDFLSHNLQKFSRAQEQHWWIGLHTSESDGRF
RWTDGSIINFISWAPGKPRPVGKDKKCVYMTASREDWGDQRCLTALPYICKRSNVTKETQ
PPDLPTTALGGCPSDWIQFLNKCFQVQGQEPQSRVKWSEAQFSCEQQEAQLVTITNPLEQ
AFITASLPNVTFDLWIGLHASQRDFQWVEQEPLMYANWAPGEPSGPSPAPSGNKPTSCAV
VLHSPSAHFTGRWDDRSCTEETHGFICQKGTDPSLSPSPAALPPAPGTELSYLNGTFRLL
QKPLRWHDALLLCESHNASLAYVPDPYTQAFLTQAARGLRTPLWIGLAGEEGSRRYSWVS
EEPLNYVGWQDGEPQQPGGCTYVDVDGAWRTTSCDTKLQGAVCGVSSGPPPPRRISYHGS
CPQGLADSAWIPFREHCYSFHMELLLGHKEARQRCQRAGGAVLSILDEMENVFVWEHLQS
YEGQSRGAWLGMNFNPKGGTLVWQDNTAVNYSNWGPPGLGPSMLSHNSCYWIQSNSGLWR
PGACTNITMGVVCKLPRAEQSSFSPSALPENPAALVVVLMAVLLLLALLTAALILYRRRQ
SIERGAFEGARYSRSSSSPTEATEKNILVSDMEMNEQQE
|
| External Links |
|---|
| GenBank ID Protein
| 110624774 |
| UniProtKB/Swiss-Prot ID
| Q9UBG0 |
| UniProtKB/Swiss-Prot Entry Name
| MRC2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_006039.3 |
| GeneCard ID
| MRC2 |
| GenAtlas ID
| MRC2 |
| HGNC ID
| HGNC:16875 |
| References |
|---|
| General References
| Not Available |