| Identification |
|---|
| HMDB Protein ID
| CDBP03027 |
| Secondary Accession Numbers
| Not Available |
| Name
| Matrix metalloproteinase-28 |
| Description
| Not Available |
| Synonyms
|
- Epilysin
- MMP-28
|
| Gene Name
| MMP28 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in metalloendopeptidase activity |
| Specific Function
| Can degrade casein. Could play a role in tissues homeostasis and repair |
| GO Classification
|
| Component |
| extracellular region part |
| extracellular matrix |
| Function |
| transition metal ion binding |
| zinc ion binding |
| metalloendopeptidase activity |
| peptidase activity |
| peptidase activity, acting on l-amino acid peptides |
| metallopeptidase activity |
| calcium ion binding |
| endopeptidase activity |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| catalytic activity |
| hydrolase activity |
| Process |
| metabolic process |
| macromolecule metabolic process |
| protein metabolic process |
| proteolysis |
|
| Cellular Location
|
- Secreted
- extracellular space
- extracellular matrix
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 17q21.1 |
| SNPs
| MMP28 |
| Gene Sequence
|
>1563 bp
ATGGTCGCGCGCGTCGGCCTCCTGCTGCGCGCCCTGCAGCTGCTACTGTGGGGCCACCTG
GACGCCCAGCCCGCGGAGCGCGGAGGCCAGGAGCTGCGCAAGGAGGCGGAGGCATTCCTA
GAGAAGTACGGATACCTCAATGAACAGGTCCCCAAAGCTCCCACCTCCACTCGATTCAGC
GATGCCATCAGAGCGTTTCAGTGGGTGTCCCAGCTACCTGTCAGCGGCGTGTTGGACCGC
GCCACCCTGCGCCAGATGACTCGTCCCCGCTGCGGGGTTACAGATACCAACAGTTATGCG
GCCTGGGCTGAGAGGATCAGTGACTTGTTTGCTAGACACCGGACCAAAATGAGGCGTAAG
AAACGCTTTGCAAAGCAAGGTAACAAATGGTACAAGCAGCACCTCTCCTACCGCCTGGTG
AACTGGCCTGAGCATCTGCCGGAGCCGGCAGTTCGGGGCGCCGTGCGCGCCGCCTTCCAG
TTGTGGAGCAACGTCTCAGCGCTGGAGTTCTGGGAGGCCCCAGCCACAGGCCCCGCTGAC
ATCCGGCTCACCTTCTTCCAAGGGGACCACAACGATGGGCTGGGCAATGCCTTTGATGGC
CCAGGGGGCGCCCTGGCGCACGCCTTCCTGCCCCGCCGCGGCGAAGCGCACTTCGACCAA
GATGAGCGCTGGTCCCTGAGCCGCCGCCGCGGGCGCAACCTGTTCGTGGTGCTGGCGCAC
GAGATCGGTCACACGCTTGGCCTCACCCACTCGCCCGCGCCGCGCGCGCTCATGGCGCCC
TACTACAAGAGGCTGGGCCGCGACGCGCTGCTCAGCTGGGACGACGTGCTGGCCGTGCAG
AGCCTGTATGGGAAGCCCCTAGGGGGCTCAGTGGCCGTCCAGCTCCCAGGAAAGCTGTTC
ACTGACTTTGAGACCTGGGACTCCTACAGCCCCCAAGGAAGGCGCCCTGAAACGCAGGGC
CCTAAATACTGCCACTCTTCCTTCGATGCCATCACTGTAGACAGGCAACAGCAACTGTAC
ATTTTTAAAGGGAGCCATTTCTGGGAGGTGGCAGCTGATGGCAACGTCTCAGAGCCCCGT
CCACTGCAGGAAAGATGGGTCGGGCTGCCCCCCAACATTGAGGCTGCGGCAGTGTCATTG
AATGATGGAGATTTCTACTTCTTCAAAGGGGGTCGATGCTGGAGGTTCCGGGGCCCCAAG
CCAGTGTGGGGTCTCCCACAGCTGTGCCGGGCAGGGGGCCTGCCCCGCCATCCTGACGCC
GCCCTCTTCTTCCCTCCTCTGCGCCGCCTCATCCTCTTCAAGGGTGCCCGCTACTACGTG
CTGGCCCGAGGGGGACTGCAAGTGGAGCCCTACTACCCCCGAAGTCTGCAGGACTGGGGA
GGCATCCCTGAGGAGGTCAGCGGCGCCCTGCCGAGGCCCGATGGCTCCATCATCTTCTTC
CGAGATGACCGCTACTGGTGCCTCGACCAGGCCAAACTGCAGGCAACCACCTCGGGCCGC
TGGGCCACCGAGCTGCCCTGGATGGGCTGCTGGCATGCCAACTCGGGGAGCGCCCTGTTC
TGA
|
| Protein Properties |
|---|
| Number of Residues
| 520 |
| Molecular Weight
| 58938.5 |
| Theoretical pI
| 10.07 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Matrix metalloproteinase-28
MVARVGLLLRALQLLLWGHLDAQPAERGGQELRKEAEAFLEKYGYLNEQVPKAPTSTRFS
DAIRAFQWVSQLPVSGVLDRATLRQMTRPRCGVTDTNSYAAWAERISDLFARHRTKMRRK
KRFAKQGNKWYKQHLSYRLVNWPEHLPEPAVRGAVRAAFQLWSNVSALEFWEAPATGPAD
IRLTFFQGDHNDGLGNAFDGPGGALAHAFLPRRGEAHFDQDERWSLSRRRGRNLFVVLAH
EIGHTLGLTHSPAPRALMAPYYKRLGRDALLSWDDVLAVQSLYGKPLGGSVAVQLPGKLF
TDFETWDSYSPQGRRPETQGPKYCHSSFDAITVDRQQQLYIFKGSHFWEVAADGNVSEPR
PLQERWVGLPPNIEAAAVSLNDGDFYFFKGGRCWRFRGPKPVWGLPQLCRAGGLPRHPDA
ALFFPPLRRLILFKGARYYVLARGGLQVEPYYPRSLQDWGGIPEEVSGALPRPDGSIIFF
RDDRYWRLDQAKLQATTSGRWATELPWMGCWHANSGSALF
|
| External Links |
|---|
| GenBank ID Protein
| 11935132 |
| UniProtKB/Swiss-Prot ID
| Q9H239 |
| UniProtKB/Swiss-Prot Entry Name
| MMP28_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF315683 |
| GeneCard ID
| MMP28 |
| GenAtlas ID
| MMP28 |
| HGNC ID
| HGNC:14366 |
| References |
|---|
| General References
| Not Available |