| Identification |
|---|
| HMDB Protein ID
| CDBP03010 |
| Secondary Accession Numbers
| Not Available |
| Name
| Cytokine-dependent hematopoietic cell linker |
| Description
| Not Available |
| Synonyms
|
- Mast cell immunoreceptor signal transducer
|
| Gene Name
| CLNK |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Plays a role in the regulation of immunoreceptor signaling, including PLC-gamma-mediated B-cell antigen receptor (BCR) signaling and FC-epsilon R1-mediated mast cell degranulation. Involved in phosphorylation of LAT |
| GO Classification
|
| Function |
| binding |
| protein binding |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:4 |
| Locus
| 4p16.1 |
| SNPs
| CLNK |
| Gene Sequence
|
>1287 bp
ATGAACAGGCAGGGCAATAGAAAGACAACTAAAGAAGGATCCAACGATTTGAAATTCCAG
AACTTCAGTCTGCCAAAAAACAGGTCATGGCCTCGCATCAATAGTGCCACAGGCCAGTAC
CAGAGGATGAACAAGCCTCTTCTAGACTGGGAAAGAAACTTTGCTGCAGTCCTGGATGGA
GCAAAAGGCCACAGTGATGATGACTATGATGACCCTGAGCTTCGGATGGAAGAGACATGG
CAGTCGATTAAAATTTTACCAGCCCGGCCTATAAAGGAATCTGAATATGCAGATACACAC
TATTTCAAGGTTGCAATGGACACTCCCCTTCCGTTAGACACCAGGACCTCTATCTCCATT
GGACAGCCGACCTGGAACACACAGACGAGGTTGGAAAGAGTGGACAAACCCATTTCCAAG
GACGTCAGAAGCCAAAACATTAAAGGAGATGCATCCGTAAGAAAGAACAAGATTCCTTTA
CCACCTCCTCGGCCTCTCATAACACTTCCGAAGAAGTACCAACCCTTGCCCCCTGAGCCG
GAGAGCAGCAGGCCACCTTTATCTCAGAGACACACCTTTCCAGAAGTCCAGAGAATGCCC
AGTCAGATAAGCTTAAGGGACTTAAGTGAGGTCCTTGAAGCAGAAAAAGTTCCTCATAAC
CAGAGGAAGCCTGAATCAACTCATCTGTTAGAAAACCAAAATACTCAAGAGATTCCACTT
GCCATTAGCAGTTCTTCATTCACGACAAGCAACCACAGTGTGCAAAACAGAGATCATAGA
GGAGGCATGCAGCCCTGTTCTCCTCAGAGATGCCAGCCTCCAGCCAGCTGCAGCCCTCAC
GAAAATATACTGCCCTATAAATACACAAGCTGGAGACCACCTTTCCCCAAAAGGTCTGAT
AGAAAGGATGTCCAGCACAATGAATGGTACATTGGAGAATACAGCCGCCAGGCAGTGGAA
GAGGCATTCATGAAGGAGAACAAGGATGGTAGTTTCTTGGTCCGAGATTGTTCCACAAAA
TCCAAGGAAGAGCCCTATGTTTTGGCTGTGTTTTATGAGAACAAAGTCTACAATGTAAAA
ATCCGCTTCCTGGAGAGGAATCAGCAGTTTGCCCTGGGGACAGGACTCAGAGGAGATGAG
AAGTTTGATTCAGTAGAAGACATCATCGAACACTACAAGAATTTTCCCATTATACTAATT
GATGGGAAAGATAAAACTGGGGTCCACAGGAAACAGTGTCACCTCACTCAGCCACTCCCT
CTCACCAGACACCTCTTGCCTCTGTAG
|
| Protein Properties |
|---|
| Number of Residues
| 428 |
| Molecular Weight
| 49553.6 |
| Theoretical pI
| 9.44 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Cytokine-dependent hematopoietic cell linker
MNRQGNRKTTKEGSNDLKFQNFSLPKNRSWPRINSATGQYQRMNKPLLDWERNFAAVLDG
AKGHSDDDYDDPELRMEETWQSIKILPARPIKESEYADTHYFKVAMDTPLPLDTRTSISI
GQPTWNTQTRLERVDKPISKDVRSQNIKGDASVRKNKIPLPPPRPLITLPKKYQPLPPEP
ESSRPPLSQRHTFPEVQRMPSQISLRDLSEVLEAEKVPHNQRKPESTHLLENQNTQEIPL
AISSSSFTTSNHSVQNRDHRGGMQPCSPQRCQPPASCSPHENILPYKYTSWRPPFPKRSD
RKDVQHNEWYIGEYSRQAVEEAFMKENKDGSFLVRDCSTKSKEEPYVLAVFYENKVYNVK
IRFLERNQQFALGTGLRGDEKFDSVEDIIEHYKNFPIILIDGKDKTGVHRKQCHLTQPLP
LTRHLLPL
|
| External Links |
|---|
| GenBank ID Protein
| 193083221 |
| UniProtKB/Swiss-Prot ID
| Q7Z7G1 |
| UniProtKB/Swiss-Prot Entry Name
| CLNK_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_052964.2 |
| GeneCard ID
| CLNK |
| GenAtlas ID
| CLNK |
| HGNC ID
| HGNC:17438 |
| References |
|---|
| General References
| Not Available |