| Identification |
|---|
| HMDB Protein ID
| CDBP03002 |
| Secondary Accession Numbers
| Not Available |
| Name
| Leukotriene B4 receptor 2 |
| Description
| Not Available |
| Synonyms
|
- LTB4 receptor JULF2
- LTB4-R 2
- LTB4-R2
- Leukotriene B4 receptor BLT2
- Seven transmembrane receptor BLTR2
- SubName: HCG2043009
|
| Gene Name
| LTB4R2 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in G-protein coupled receptor protein signaling pathway |
| Specific Function
| Low-affinity receptor for leukotrienes including leukotriene B4. Mediates chemotaxis of granulocytes and macrophages. The response is mediated via G-proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of affinities for the leukotrienes is LTB4 > 12-epi-LTB4 > LTB5 > LTB3 |
| GO Classification
|
| Component |
| integral to membrane |
| cell part |
| membrane part |
| intrinsic to membrane |
| Function |
| receptor activity |
| transmembrane receptor activity |
| molecular transducer activity |
| signal transducer activity |
| leukotriene receptor activity |
| g-protein coupled receptor activity |
| Process |
| signaling |
| signaling pathway |
| cell surface receptor linked signaling pathway |
| g-protein coupled receptor protein signaling pathway |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 14q11.2-q12 |
| SNPs
| LTB4R2 |
| Gene Sequence
|
>1170 bp
ATGGCACCTTCTCATCGGGCATCACAGGTGGGGTTTTGCCCCACCCCTGAACGCCCTCTG
TGGCGCCTTCCACCCACCTGTAGGCCCAGAAGGATGTCGGTCTGCTACCGTCCCCCAGGG
AACGAGACACTGCTGAGCTGGAAGACTTCGCGGGCCACAGGCACAGCCTTCCTGCTGCTG
GCGGCGCTGCTGGGGCTGCCTGGCAACGGCTTCGTGGTGTGGAGCTTGGCGGGCTGGCGG
CCTGCACGGGGGCGACCGCTGGCGGCCACGCTTGTGCTGCACCTGGCGCTGGCCGACGGC
GCGGTGCTGCTGCTCACGCCGCTCTTTGTGGCCTTCCTGACCCGGCAGGCCTGGCCGCTG
GGCCAGGCGGGCTGCAAGGCGGTGTACTACGTGTGCGCGCTCAGCATGTACGCCAGCGTG
CTGCTCACCGGCCTGCTCAGCCTGCAGCGCTGCCTCGCAGTCACCCGCCCCTTCCTGGCG
CCTCGGCTGCGCAGCCCGGCCCTGGCCCGCCGCCTGCTGCTGGCGGTCTGGCTGGCCGCC
CTGTTGCTCGCCGTCCCGGCCGCCGTCTACCGCCACCTGTGGAGGGACCGCGTATGCCAG
CTGTGCCACCCGTCGCCGGTCCACGCCGCCGCCCACCTGAGCCTGGAGACTCTGACCGCT
TTCGTGCTTCCTTTCGGGCTGATGCTCGGCTGCTACAGCGTGACGCTGGCACGGCTGCGG
GGCGCCCGCTGGGGCTCCGGGCGGCACGGGGCGCGGGTGGGCCGGCTGGTGAGCGCCATC
GTGCTTGCCTTCGGCTTGCTCTGGGCCCCCTACCACGCAGTCAACCTTCTGCAGGCGGTC
GCAGCGCTGGCTCCACCGGAAGGGGCCTTGGCGAAGCTGGGCGGAGCCGGCCAGGCGGCG
CGAGCGGGAACTACGGCCTTGGCCTTCTTCAGTTCTAGCGTCAACCCGGTGCTCTACGTC
TTCACCGCTGGAGATCTGCTGCCCCGGGCAGGTCCCCGTTTCCTCACGCGGCTCTTCGAA
GGCTCTGGGGAGGCCCGAGGGGGCGGCCGCTCTAGGGAAGGGACCATGGAGCTCCGAACT
ACCCCTCAGCTGAAAGTGGTGGGGCAGGGCCGCGGCAATGGAGACCCGGGGGGTGGGATG
GAGAAGGACGGTCCGGAATGGGACCTTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 389 |
| Molecular Weight
| 41524.3 |
| Theoretical pI
| 11.49 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["56-76", "92-112", "128-148", "173-193", "217-237", "257-277", "307-327"]
|
| Protein Sequence
|
>Leukotriene B4 receptor 2
MAPSHRASQVGFCPTPERPLWRLPPTCRPRRMSVCYRPPGNETLLSWKTSRATGTAFLLL
AALLGLPGNGFVVWSLAGWRPARGRPLAATLVLHLALADGAVLLLTPLFVAFLTRQAWPL
GQAGCKAVYYVCALSMYASVLLTGLLSLQRCLAVTRPFLAPRLRSPALARRLLLAVWLAA
LLLAVPAAVYRHLWRDRVCQLCHPSPVHAAAHLSLETLTAFVLPFGLMLGCYSVTLARLR
GARWGSGRHGARVGRLVSAIVLAFGLLWAPYHAVNLLQAVAALAPPEGALAKLGGAGQAA
RAGTTALAFFSSSVNPVLYVFTAGDLLPRAGPRFLTRLFEGSGEARGGGRSREGTMELRT
TPQLKVVGQGRGNGDPGGGMEKDGPEWDL
|
| External Links |
|---|
| GenBank ID Protein
| 57157113 |
| UniProtKB/Swiss-Prot ID
| Q9NPC1 |
| UniProtKB/Swiss-Prot Entry Name
| LT4R2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF277230 |
| GeneCard ID
| LTB4R2 |
| GenAtlas ID
| LTB4R2 |
| HGNC ID
| HGNC:19260 |
| References |
|---|
| General References
| Not Available |