| Identification |
|---|
| HMDB Protein ID
| CDBP02995 |
| Secondary Accession Numbers
| Not Available |
| Name
| Leukocyte immunoglobulin-like receptor subfamily B member 2 |
| Description
| Not Available |
| Synonyms
|
- CD85 antigen-like family member D
- CD85d antigen
- ILT-4
- Immunoglobulin-like transcript 4
- LIR-2
- Leukocyte immunoglobulin-like receptor 2
- MIR-10
- Monocyte/macrophage immunoglobulin-like receptor 10
|
| Gene Name
| LILRB2 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in receptor activity |
| Specific Function
| Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Involved in the down-regulation of the immune response and the development of tolerance. Competes with CD8A for binding to class I MHC antigens. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Membrane
- Single-pass type I membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19q13.4 |
| SNPs
| LILRB2 |
| Gene Sequence
|
>1797 bp
ATGACCCCCATCGTCACAGTCCTGATCTGTCTCGGGCTGAGTCTGGGCCCCAGGACCCAC
GTGCAGACAGGGACCATTCCCAAGCCCACCCTGTGGGCTGAGCCAGACTCTGTGATCACC
CAGGGGAGTCCCGTCACCCTCAGTTGTCAGGGGAGCCTTGAAGCCCAGGAGTACCGTCTA
TATAGGGAGAAAAAATCAGCATCTTGGATTACACGGATACGACCAGAGCTTGTGAAGAAC
GGCCAGTTCCACATCCCATCCATCACCTGGGAACACACAGGGCGATATGGCTGTCAGTAT
TACAGCCGCGCTCGGTGGTCTGAGCTCAGTGACCCCCTGGTGCTGGTGATGACAGGAGCC
TACCCAAAACCCACCCTCTCAGCCCAGCCCAGCCCTGTGGTGACCTCAGGAGGAAGGGTG
ACCCTCCAGTGTGAGTCACAGGTGGCATTTGGCGGCTTCATTCTGTGTAAGGAAGGAGAA
GAAGAACACCCACAATGCCTGAACTCCCAGCCCCATGCCCGTGGGTCGTCCCGCGCCATC
TTCTCCGTGGGCCCCGTGAGCCCGAATCGCAGGTGGTCGCACAGGTGCTATGGTTATGAC
TTGAACTCTCCCTATGTGTGGTCTTCACCCAGTGATCTCCTGGAGCTCCTGGTCCCAGGT
GTTTCTAAGAAGCCATCACTCTCAGTGCAGCCGGGTCCTGTCGTGGCCCCTGGGGAAAGC
CTGACCCTCCAGTGTGTCTCTGATGTCGGCTATGACAGATTTGTTCTGTACAAGGAGGGG
GAACGTGACCTTCGCCAGCTCCCTGGCCGGCAGCCCCAGGCTGGGCTCTCCCAGGCCAAC
TTCACCCTGGGCCCTGTGAGCCGCTCCTACGGGGGCCAGTACAGATGCTACGGTGCACAC
AACCTCTCCTCTGAGTGCTCGGCCCCCAGCGACCCCCTGGACATCCTGATCACAGGACAG
ATCCGTGGCACACCCTTCATCTCAGTGCAGCCAGGCCCCACAGTGGCCTCAGGAGAGAAC
GTGACCCTGCTGTGTCAGTCATGGCGGCAGTTCCACACTTTCCTTCTGACCAAGGCGGGA
GCAGCTGATGCCCCACTCCGTCTAAGATCAATACACGAATATCCTAAGTACCAGGCTGAA
TTCCCCATGAGTCCTGTGACCTCAGCCCACGCGGGGACCTACAGGTGCTACGGCTCACTC
AACTCCGACCCCTACCTGCTGTCTCACCCCAGTGAGCCCCTGGAGCTCGTGGTCTCAGGA
CCCTCCATGGGTTCCAGCCCCCCACCCACCGGTCCCATCTCCACACCTGCAGGCCCTGAG
GACCAGCCCCTCACCCCCACTGGGTCGGATCCCCAAAGTGGTCTGGGAAGGCACCTGGGG
GTTGTGATCGGCATCTTGGTGGCCGTCGTCCTACTGCTCCTCCTCCTCCTCCTCCTCTTC
CTCATCCTCCGACATCGACGTCAGGGCAAACACTGGACATCGACCCAGAGAAAGGCTGAT
TTCCAACATCCTGCAGGGGCTGTGGGGCCAGAGCCCACAGACAGAGGCCTGCAGTGGAGG
TCCAGCCCAGCTGCCGACGCCCAGGAAGAAAACCTCTATGCTGCCGTGAAGGACACACAG
CCTGAAGATGGGGTGGAGATGGACACTCGGGCTGCTGCATCTGAAGCCCCCCAGGATGTG
ACCTACGCCCAGCTGCACAGCTTGACCCTCAGACGGAAGGCAACTGAGCCTCCTCCATCC
CAGGAAAGGGAACCTCCAGCTGAGCCCAGCATCTACGCCACCCTGGCCATCCACTAG
|
| Protein Properties |
|---|
| Number of Residues
| 598 |
| Molecular Weight
| 65133.1 |
| Theoretical pI
| 7.22 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Leukocyte immunoglobulin-like receptor subfamily B member 2
MTPIVTVLICLGLSLGPRTHVQTGTIPKPTLWAEPDSVITQGSPVTLSCQGSLEAQEYRL
YREKKSASWITRIRPELVKNGQFHIPSITWEHTGRYGCQYYSRARWSELSDPLVLVMTGA
YPKPTLSAQPSPVVTSGGRVTLQCESQVAFGGFILCKEGEDEHPQCLNSQPHARGSSRAI
FSVGPVSPNRRWSHRCYGYDLNSPYVWSSPSDLLELLVPGVSKKPSLSVQPGPVVAPGES
LTLQCVSDVGYDRFVLYKEGERDLRQLPGRQPQAGLSQANFTLGPVSRSYGGQYRCYGAY
NLSSEWSAPSDPLDILITGQIRGTPFISVQPGPTVASGENVTLLCQSWRQFHTFLLTKAG
AADAPLRLRSIHEYPKYQAEFPMSPVTSAHAGTYRCYGSLNSDPYLLSHPSEPLELVVSG
PSMGSSPPPTGPISTPAGPEDQPLTPTGSDPQSGLGRHLGVVIGILVAVVLLLLLLLLLF
LILRHRRQGKHWTSTQRKADFQHPAGAVGPEPTDRGLQWRSSPAADAQEENLYAAVKDTQ
PEDGVEMDTRAAASEAPQDVTYAQLHSLTLRRKATEPPPSQEREPPAEPSIYATLAIH
|
| External Links |
|---|
| GenBank ID Protein
| 125988400 |
| UniProtKB/Swiss-Prot ID
| Q8N423 |
| UniProtKB/Swiss-Prot Entry Name
| LIRB2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_005874.3 |
| GeneCard ID
| LILRB2 |
| GenAtlas ID
| LILRB2 |
| HGNC ID
| HGNC:6606 |
| References |
|---|
| General References
| Not Available |