| Identification |
|---|
| HMDB Protein ID
| CDBP02994 |
| Secondary Accession Numbers
| Not Available |
| Name
| Leukocyte immunoglobulin-like receptor subfamily B member 1 |
| Description
| Not Available |
| Synonyms
|
- CD85 antigen-like family member J
- CD85j antigen
- ILT-2
- Immunoglobulin-like transcript 2
- LIR-1
- Leukocyte immunoglobulin-like receptor 1
- MIR-7
- Monocyte/macrophage immunoglobulin-like receptor 7
|
| Gene Name
| LILRB1 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in protein phosphatase 1 binding |
| Specific Function
| Receptor for class I MHC antigens. Recognizes a broad spectrum of HLA-A, HLA-B, HLA-C and HLA-G alleles. Receptor for H301/UL18, a human cytomegalovirus class I MHC homolog. Ligand binding results in inhibitory signals and down-regulation of the immune response. Engagement of LILRB1 present on natural killer cells or T-cells by class I MHC molecules protects the target cells from lysis. Interaction with HLA-B or HLA-E leads to inhibition of the signal triggered by FCER1A and inhibits serotonin release. Inhibits FCGR1A-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Membrane
- Single-pass type I membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19q13.4 |
| SNPs
| LILRB1 |
| Gene Sequence
|
>1953 bp
ATGACCCCCATCCTCACGGTCCTGATCTGTCTCGGGCTGAGTCTGGGCCCCAGGACCCAC
GTGCAGGCAGGGCACCTCCCCAAGCCCACCCTCTGGGCTGAACCAGGCTCTGTGATCACC
CAGGGGAGTCCTGTGACCCTCAGGTGTCAGGGGGGCCAGGAGACCCAGGAGTACCGTCTA
TATAGAGAAAAGAAAACAGCACTCTGGATTACACGGATCCCACAGGAGCTTGTGAAGAAG
GGCCAGTTCCCCATCCCATCCATCACCTGGGAACATGCAGGGCGGTATCGCTGTTACTAT
GGTAGCGACACTGCAGGCCGCTCAGAGAGCAGTGACCCCCTGGAGCTGGTGGTGACAGGA
GCCTACATCAAACCCACCCTCTCAGCCCAGCCCAGCCCCGTGGTGAACTCAGGAGGGAAT
GTAATCCTCCAGTGTGACTCACAGGTGGCATTTGATGGCTTCAGTCTGTGTAAGGAAGGA
GAAGATGAACACCCACAATGCCTGAACTCCCAGCCCCATGCCCGTGGGTCGTCCCGCGCC
ATCTTCTCCGTGGGCCCCGTGAGCCCGAGTCGCAGGTGGTGGTACAGGTGCTATGCTTAT
GACTCGAACTCTCCCTATGAGTGGTCTCTACCCAGTGATCTCCTGGAGCTCCTGGTCCTA
GGTGTTTCTAAGAAGCCATCACTCTCAGTGCAGCCAGGTCCTATCGTGGCCCCTGAGGAG
ACCCTGACTCTGCAGTGTGGCTCTGATGCTGGCTACAACAGATTTGTTCTGTATAAGGAC
GGGGAACGTGACTTCCTTCAGCTCGCTGGCGCACAGCCCCAGGCTGGGCTCTCCCAGGCC
AACTTCACCCTGGGCCCTGTGAGCCGCTCCTACGGGGGCCAGTACAGATGCTACGGTGCA
CACAACCTCTCCTCCGAGTGGTCGGCCCCCAGCGACCCCCTGGACATCCTGATCGCAGGA
CAGTTCTATGACAGAGTCTCCCTCTCGGTGCAGCCGGGCCCCACGGTGGCCTCAGGAGAG
AACGTGACCCTGCTGTGTCAGTCACAGGGATGGATGCAAACTTTCCTTCTGACCAAGGAG
GGGGCAGCTGATGACCCATGGCGTCTAAGATCAACGTACCAATCTCAAAAATACCAGGCT
GAATTCCCCATGGGTCCTGTGACCTCAGCCCATGCGGGGACCTACAGGTGCTACGGCTCA
CAGAGCTCCAAACCCTACCTGCTGACTCACCCCAGTGACCCCCTGGAGCTCGTGGTCTCA
GGACCGTCTGGGGGCCCCAGCTCCCCGACAACAGGCCCCACCTCCACATCTGGCCCTGAG
GACCAGCCCCTCACCCCCACCGGGTCGGATCCCCAGAGTGGTCTGGGAAGGCACCTGGGG
GTTGTGATCGGCATCTTGGTGGCCGTCATCCTACTGCTCCTCCTCCTCCTCCTCCTCTTC
CTCATCCTCCGACATCGACGTCAGGGCAAACACTGGACATCGACCCAGAGAAAGGCTGAT
TTCCAACATCCTGCAGGGGCTGTGGGGCCAGAGCCCACAGACAGAGGCCTGCAGTGGAGG
TCCAGCCCAGCTGCCGATGCCCAGGAAGAAAACCTCTATGCTGCCGTGAAGCACACACAG
CCTGAGGATGGGGTGGAGATGGACACTCGGAGCCCACACGATGAAGACCCCCAGGCAGTG
ACGTATGCCGAGGTGAAACACTCCAGACCTAGGAGAGAAATGGCCTCTCCTCCTTCCCCA
CTGTCTGGGGAATTCCTGGACACAAAGGACAGACAGGCGGAAGAGGACAGGCAGATGGAC
ACTGAGGCTGCTGCATCTGAAGCCCCCCAGGATGTGACCTACGCCCAGCTGCACAGCTTG
ACCCTCAGACGGGAGGCAACTGAGCCTCCTCCATCCCAGGAAGGGCCCTCTCCAGCTGTG
CCCAGCATCTACGCCACTCTGGCCATCCACTAG
|
| Protein Properties |
|---|
| Number of Residues
| 650 |
| Molecular Weight
| 70818.8 |
| Theoretical pI
| 5.95 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Leukocyte immunoglobulin-like receptor subfamily B member 1
MTPILTVLICLGLSLGPRTHVQAGHLPKPTLWAEPGSVITQGSPVTLRCQGGQETQEYRL
YREKKTALWITRIPQELVKKGQFPIPSITWEHAGRYRCYYGSDTAGRSESSDPLELVVTG
AYIKPTLSAQPSPVVNSGGNVILQCDSQVAFDGFSLCKEGEDEHPQCLNSQPHARGSSRA
IFSVGPVSPSRRWWYRCYAYDSNSPYEWSLPSDLLELLVLGVSKKPSLSVQPGPIVAPEE
TLTLQCGSDAGYNRFVLYKDGERDFLQLAGAQPQAGLSQANFTLGPVSRSYGGQYRCYGA
HNLSSEWSAPSDPLDILIAGQFYDRVSLSVQPGPTVASGENVTLLCQSQGWMQTFLLTKE
GAADDPWRLRSTYQSQKYQAEFPMGPVTSAHAGTYRCYGSQSSKPYLLTHPSDPLELVVS
GPSGGPSSPTTGPTSTSGPEDQPLTPTGSDPQSGLGRHLGVVIGILVAVILLLLLLLLLF
LILRHRRQGKHWTSTQRKADFQHPAGAVGPEPTDRGLQWRSSPAADAQEENLYAAVKHTQ
PEDGVEMDTRSPHDEDPQAVTYAEVKHSRPRREMASPPSPLSGEFLDTKDRQAEEDRQMD
TEAAASEAPQDVTYAQLHSLTLRREATEPPPSQEGPSPAVPSIYATLAIH
|
| External Links |
|---|
| GenBank ID Protein
| 116488411 |
| UniProtKB/Swiss-Prot ID
| Q8NHL6 |
| UniProtKB/Swiss-Prot Entry Name
| LIRB1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| NM_006669.3 |
| GeneCard ID
| LILRB1 |
| GenAtlas ID
| LILRB1 |
| HGNC ID
| HGNC:6605 |
| References |
|---|
| General References
| Not Available |