| Identification |
|---|
| HMDB Protein ID
| CDBP02978 |
| Secondary Accession Numbers
| Not Available |
| Name
| Potassium channel subfamily U member 1 |
| Description
| Not Available |
| Synonyms
|
- Calcium-activated potassium channel subunit alpha-3
- Calcium-activated potassium channel, subfamily M subunit alpha-3
- KCa5
- Slowpoke homolog 3
|
| Gene Name
| KCNU1 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in ion channel activity |
| Specific Function
| Testis-specific potassium channel activated by both intracellular pH and membrane voltage that mediates export of K(+). May be involved in sperm capacitation and/or the acrosome reaction, essential steps in fertilization where changes in both intracellular pH and membrane potential are known to occur. In contrast to KCNMA1/SLO1, it is not activated by Ca(2+) or Mg(2+) |
| GO Classification
|
| Component |
| membrane |
| cell part |
| Function |
| calcium activated cation channel activity |
| calcium-activated potassium channel activity |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| ion transmembrane transporter activity |
| transporter activity |
| ion channel activity |
| cation channel activity |
| Process |
| establishment of localization |
| transport |
| transmembrane transport |
| monovalent inorganic cation transport |
| potassium ion transport |
| ion transport |
| cation transport |
|
| Cellular Location
|
- Membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:8 |
| Locus
| 8p11.23 |
| SNPs
| KCNU1 |
| Gene Sequence
|
>3450 bp
ATGTTTCAGACTAAGCTACGAAATGAAACTTGGGAAGACTTGCCAAAAATGTCCTGCACA
ACTGAGATCCAAGCAGCATTCATTCTCTCTTCCTTTGTGACCTTCTTCAGTGGACTCATC
ATCCTGTTGATCTTCAGGCTGATCTGGAGATCTGTTAAAAAATGGCAAATCATCAAGGGA
ACAGGAATTATCTTGGAACTGTTCACATCAGGTACCATCGCTAGGAGCCATGTAAGAAGC
CTCCACTTCCAGGGACAATTTCGTGATCATATAGAAATGTTGCTTTCAGCCCAGACCTTT
GTGGGGCAAGTGTTGGTGATCCTTGTCTTTGTACTAAGCATTGGGTCTCTTATAATCTAT
TTCATCAATTCTGCTGACCCTGTTGGAAGCTGTTCATCATATGAAGACAAAACCATTCCT
ATTGATTTGGTTTTCAATGCTTTCTTTAGTTTCTATTTTGGATTGAGGTTTATGGCAGCT
GATGACAAGATCAAGTTCTGGCTGGAGATGAATTCAATCGTAGACATCTTTACCATCCCA
CCAACCTTTATTTCTTATTATTTGAAGAGCAATTGGCTAGGTTTAAGGTTCCTAAGAGCC
TTGCGCCTGCTAGAACTCCCTCAAATCTTGCAAATTCTACGAGCCATCAAGACCAGTAAC
TCAGTGAAGTTTTCCAAACTGCTGTCAATAATTCTCAGTACCTGGTTCACAGCTGCGGGA
TTCATTCACCTGGTGGAAAATTCTGGTGATCCCTGGCTCAAAGGTAGAAATTCACAGAAT
ATATCATATTTTGAGTCAATTTACCTGGTCATGGCAACAACGTCAACCGTTGGATTTGGA
GATGTGGTAGCCAAGACATCCTTAGGACGGACCTTCATCATGTTCTTCACACTGGGGAGT
TTGATATTATTTGCGAACTATATACCTGAAATGGTGGAACTGTTTGCTAACAAGAGGAAA
TACACCAGTTCCTATGAAGCACTCAAAGGAAAGAAGTTTATTGTGGTCTGTGGAAACATC
ACTGTGGACAGTGTGACCGCTTTCCTGAGGAATTTCCTCCGCGACAAGTCAGGAGAGATC
AACACTGAAATTGTTTTCCTGGGAGAAACCCCTCCTTCTTTGGAACTTGAAACCATATTT
AAATGCTACTTGGCCTACACAACGTTCATTTCTGGATCTGCAATGAAGTGGGAGGATCTG
AGGCGAGTTGCGGTGGAATCTGCAGAGGCATGCCTGATTATAGCCAATCCTTTGTGCAGT
GATTCCCATGCTGAAGATATTTCCAACATTATGAGGGTGCTCTCTATCAAGAACTATGAT
TCTACCACCAGAATCATCATACAGATACTGCAATCCCATAACAAGGTTTATCTGCCAAAG
ATTCCCAGCTGGAACTGGGACACCGGAGACAACATCATCTGCTTTGCTGAATTAAAACTT
GGATTTATCGCCCAAGGCTGTTTGGTGCCAGGCTTGTGTACCTTCCTAACATCTCTATTT
GTGGAGCAAAACAAAAAGGTTATGCCTAAACAGACCTGGAAGAAACACTTCTTGAATAGC
ATGAAAAACAAAATTCTGACCCAACGTCTCTCTGATGACTTTGCTGGAATGAGCTTTCCT
GAAGTTGCCCGGCTCTGCTTTCTGAAGATGCACCTCCTGTTGATAGCCATCGAATACAAG
TCCCTCTTTACGGATGGTTTCTGTGGTCTGATACTAAATCCACCTCCACAAGTGAGGATA
CGTAAGAACACATTAGGGTTCTTTATTGCTGAAACTCCAAAGGACGTCAGAAGAGCCTTG
TTTTACTGTTCAGTCTGTCATGATGATGTGTTCATTCCTGAGCTAATTACAAACTGTGGC
TGCAAAAGCAGAAGCCGGCAGCACATCACAGTGCCATCGGTAAAGAGAATGAAAAAATGT
CTGAAGGGAATCTCCTCTCGTATATCAGGGCAGGATTCTCCGCCAAGGGTATCTGCAAGC
ACTTCGAGCATATCAAACTTCACCACCAGGACTCTTCAACATGATGTAGAACAAGATTCT
GACCAGCTTGATAGCAGTGGGATGTTTCACTGGTGCAAACCAACCTCTTTGGACAAGGTG
ACTCTGAAACGAACTGGCAAGTCAAAGTATAAGTTTCGGAACCATATTGTAGCATGTGTA
TTTGGAGATGCCCACTCAGCCCCGATGGGGCTTCGGAACTTTGTAATGCCCTTGAGAGCC
AGCAACTATACCAGGAAGGAGCTGAAGGACATAGTGTTCATTGGGTCTCTGGACTATCTA
CAGAGAGAATGGCGATTTCTCTGGAATTTTCCCCAGATATACATTCTGCCTGGATGTGCA
CTTTATTCTGGAGACCTCCATGCGGCCAACATAGAGCAATGCTCCATGTGTGCTGTCTTG
TCCCCCCCACCCCAGCCATCAAGCAACCAGACTTTGGTAGACACAGAAGCCATCATGGCA
ACCCTCACCATCGGATCCTTGCAAATTGACTCCTCCTCTGACCCGTCACCCTCAGTGTCA
GAGGAGACTCCAGGTTACACAAATGGACATAATGAGAAATCAAACTGCCGAAAAGTCCCT
ATCCTTACTGAACTGAAAAATCCTTCCAACATTCACTTTATTGAACAGCTTGGTGGACTG
GAAGGGTCCCTCCAAGAAACAAATCTGCATCTCAGCACTGCCTTTTCTACGGGCACTGTT
TTTTCCGGCAGCTTCTTGGATTCTCTGCTGGCCACGGCCTTCTACAATTATCATGTCCTG
GAATTGCTTCAGATGCTGGTGACAGGAGGAGTAAGTTCTCAGCTGGAACAACATTTAGAT
AAGGATAAAGTCTATGGTGTGGCAGATAGCTGCACGTCGCTCTTGTCTGGAAGAAACCGG
TGTAAGCTGGGGCTTCTGTCCTTACACGAAACCATTTTATCAGACGTTAATCCAAGAAAC
ACCTTTGGACAACTGTTCTGTGGCTCATTAGATCTTTTTGGAATCCTGTGTGTTGGCTTA
TACCGAATAATTGATGAAGAGGAGCTCAACCCAGAAAACAAAAGGTTTGTGATCACCCGG
CCAGCCAATGAGTTCAAGCTGCTGCCTTCAGATCTTGTGTTTTGTGCCATACCCTTCAGC
ACTGCTTGTTATAAAAGGAATGAAGAGTTCTCATTGCAAAAGTCATATGAAATTGTAAAT
AAAGCATCACAGACAACAGAGACACATTCAGACACAAATTGTCCTCCCACCATTGATTCA
GTTACTGAGACATTGTATTCACCAGTCTATTCTTACCAGCCGAGAACTAACTCCCTCTCT
TTTCCTAAGCAAATAGCATGGAATCAGAGTAGAACAAACAGTATTATATCATCTCAGATA
CCTTTAGGTGACAATGCAAAAGAAAATGAAAGGAAAACTTCAGATGAGGTTTATGATGAG
GATCCCTTTGCATATTCAGAGCCACTATAG
|
| Protein Properties |
|---|
| Number of Residues
| 1149 |
| Molecular Weight
| 129542.0 |
| Theoretical pI
| 7.87 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["25-45", "102-122", "139-159", "164-184", "189-209", "227-247", "292-312"]
|
| Protein Sequence
|
>Potassium channel subfamily U member 1
MFQTKLRNETWEDLPKMSCTTEIQAAFILSSFVTFFSGLIILLIFRLIWRSVKKWQIIKG
TGIILELFTSGTIARSHVRSLHFQGQFRDHIEMLLSAQTFVGQVLVILVFVLSIGSLIIY
FINSADPVGSCSSYEDKTIPIDLVFNAFFSFYFGLRFMAADDKIKFWLEMNSIVDIFTIP
PTFISYYLKSNWLGLRFLRALRLLELPQILQILRAIKTSNSVKFSKLLSIILSTWFTAAG
FIHLVENSGDPWLKGRNSQNISYFESIYLVMATTSTVGFGDVVAKTSLGRTFIMFFTLGS
LILFANYIPEMVELFANKRKYTSSYEALKGKKFIVVCGNITVDSVTAFLRNFLRDKSGEI
NTEIVFLGETPPSLELETIFKCYLAYTTFISGSAMKWEDLRRVAVESAEACLIIANPLCS
DSHAEDISNIMRVLSIKNYDSTTRIIIQILQSHNKVYLPKIPSWNWDTGDNIICFAELKL
GFIAQGCLVPGLCTFLTSLFVEQNKKVMPKQTWKKHFLNSMKNKILTQRLSDDFAGMSFP
EVARLCFLKMHLLLIAIEYKSLFTDGFCGLILNPPPQVRIRKNTLGFFIAETPKDVRRAL
FYCSVCHDDVFIPELITNCGCKSRSRQHITVPSVKRMKKCLKGISSRISGQDSPPRVSAS
TSSISNFTTRTLQHDVEQDSDQLDSSGMFHWCKPTSLDKVTLKRTGKSKYKFRNHIVACV
FGDAHSAPMGLRNFVMPLRASNYTRKELKDIVFIGSLDYLQREWRFLWNFPQIYILPGCA
LYSGDLHAANIEQCSMCAVLSPPPQPSSNQTLVDTEAIMATLTIGSLQIDSSSDPSPSVS
EETPGYTNGHNEKSNCRKVPILTELKNPSNIHFIEQLGGLEGSLQETNLHLSTAFSTGTV
FSGSFLDSLLATAFYNYHVLELLQMLVTGGVSSQLEQHLDKDKVYGVADSCTSLLSGRNR
CKLGLLSLHETILSDVNPRNTFGQLFCGSLDLFGILCVGLYRIIDEEELNPENKRFVITR
PANEFKLLPSDLVFCAIPFSTACYKRNEEFSLQKSYEIVNKASQTTETHSDTNCPPTIDS
VTETLYSPVYSYQPRTNSLSFPKQIAWNQSRTNSIISSQIPLGDNAKENERKTSDEVYDE
DPFAYSEPL
|
| External Links |
|---|
| GenBank ID Protein
| 157074214 |
| UniProtKB/Swiss-Prot ID
| A8MYU2 |
| UniProtKB/Swiss-Prot Entry Name
| KCNU1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001031836.2 |
| GeneCard ID
| KCNU1 |
| GenAtlas ID
| KCNU1 |
| HGNC ID
| HGNC:18867 |
| References |
|---|
| General References
| Not Available |