| Identification |
|---|
| HMDB Protein ID
| CDBP02977 |
| Secondary Accession Numbers
| Not Available |
| Name
| Potassium channel subfamily T member 2 |
| Description
| Not Available |
| Synonyms
|
- Sequence like an intermediate conductance potassium channel subunit
- Sodium and chloride-activated ATP-sensitive potassium channel Slo2.1
|
| Gene Name
| KCNT2 |
| Protein Type
| Transporter |
| Biological Properties |
|---|
| General Function
| Involved in calcium-activated potassium channel activity |
| Specific Function
| Outward rectifying potassium channel. Produces rapidly activating outward rectifier K(+) currents. Activated by high intracellular sodium and chloride levels. Channel activity is inhibited by ATP and by inhalation anesthetics, such as isoflurane. Inhibited upon stimulation of G-protein coupled receptors, such as CHRM1 and GRIA1 |
| GO Classification
|
| Component |
| membrane |
| cell part |
| Function |
| transporter activity |
| ion channel activity |
| cation channel activity |
| calcium activated cation channel activity |
| calcium-activated potassium channel activity |
| transmembrane transporter activity |
| substrate-specific transmembrane transporter activity |
| ion transmembrane transporter activity |
| Process |
| establishment of localization |
| transport |
| monovalent inorganic cation transport |
| potassium ion transport |
| ion transport |
| cation transport |
|
| Cellular Location
|
- Cell membrane
- Multi-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1q31.3 |
| SNPs
| KCNT2 |
| Gene Sequence
|
>3408 bp
ATGGTTGATTTGGAGAGCGAAGTGCCCCCTCTGCCTCCCAGGTACAGGTTTCGAGATTTG
CTGCTAGGGGACCAAGGATGGCAAAACGACGACAGGGTACAAGTTGAATTCTATATGAAT
GAAAATACATTTAAAGAAAGACTAAAATTATTTTTCATAAAAAACCAGAGATCAAGTCTA
AGGATACGCCTGTTCAATTTTTCTCTCAAATTACTAAGCTGCTTATTATACATAATCCGA
GTACTACTAGAAAACCCTTCACAAGGAAATGAATGGTCTCATATCTTTTGGGTGAACAGA
AGTCTACCTTTGTGGGGCTTACAGGTTTCAGTGGCATTGATAAGTCTGTTTGAAACAATA
TTACTTGGTTATCTTAGTTATAAGGGAAACATCTGGGAACAGATTTTACGAATACCCTTC
ATCTTGGAAATAATTAATGCAGTTCCCTTCATTATCTCAATATTCTGGCCTTCCTTAAGG
AATCTATTTGTCCCAGTCTTTCTGAACTGTTGGCTTGCCAAACATGCCTTGGAAAATATG
ATTAATGATCTACACAGAGCCATTCAGCGTACACAGTCTGCAATGTTTAATCAAGTTTTG
ATTTTAATATCTACATTACTATGCCTTATCTTCACCTGCATTTGTGGGATCCAACATCTG
GAACGAATAGGAAAGAAGCTGAATCTCTTTGACTCCCTTTATTTCTGCATTGTGACGTTT
TCTACTGTGGGCTTCGGGGATGTCACTCCTGAAACATGGTCCTCCAAGCTTTTTGTAGTT
GCTATGATTTGTGTTGCTCTTGTGGTTCTACCCATACAGTTTGAACAGCTGGCTTATTTG
TGGATGGAGAGACAAAAGTCAGGAGGAAACTATAGTCGACATAGAGCTCAAACTGAAAAG
CATGTCGTCCTGTGTGTCAGCTCACTGAAGATTGATTTACTTATGGATTTTTTAAATGAA
TTCTATGCTCATCCTAGGCTCCAGGATTATTATGTGGTGATTTTGTGTCCTACTGAAATG
GATGTACAGGTTCGAAGGGTACTGCAGATTCCAATGTGGTCCCAACGAGTTATCTACCTT
CAAGGTTCAGCCCTTAAAGATCAAGACCTATTGAGAGCAAAGATGGATGACGCTGAGGCC
TGTTTTATTCTCAGTAGCCGTTGTGAAGTGGATAGGACATCATCTGATCACCAAACAATT
TTGAGAGCATGGGCTGTGAAAGATTTTGCTCCAAATTGTCCTTTGTATGTCCAGATATTA
AAGCCTGAAAATAAATTTCACATCAAATTTGCTGATCATGTTGTTTGTGAAGAAGAGTTT
AAATACGCCATGTTAGCTTTAAACTGTATATGCCCAGCAACATCTACACTTATTACACTA
CTGGTTCATACCTCTAGAGGGCAAGAAGGCCAGCAATCGCCAGAACAATGGCAGAAGATG
TACGGTAGATGCTCCGGGAATGAAGTCTACCACATTGTTTTGGAAGAAAGTACATTTTTT
GCTGAATATGAAGGAAAGAGTTTTACATATGCCTCTTTCCATGCACACAAAAAGTTTGGC
GTCTGCTTGATTGGTGTTAGGAGGGAGGATAATAAAAACATTTTGCTGAATCCAGGTCCT
CGATACATTATGAATTCTACAGACATATGCTTTTATATTAATATTACCAAAGAAGAGAAT
TCAGCATTTAAAAACCAAGACCAGCAGAGAAAAAGCAATGTGTCCAGGTCGTTTTATCAT
GGACCTTCCAGATTACCTGTACATAGCATAATTGCCAGCATGGGTACTGTGGCTATAGAC
TTGCAAGATACAAGCTGTAGATCAGCAAGTGGCCCTACCCTGTCTCTTCCTACAGAGGGA
AGCAAAGAAATAAGAAGACCTAGCATTGCTCCTGTTTTAGAGGTTGCAGATACATCATCG
ATTCAAACATGTGATCTTCTAAGTGACCAATCAGAAGATGAAACTACACCAGATGAAGAA
ATGTCTTCAAACTTAGAGTATGCTAAAGGTTACCCACCTTATTCTCCATATATAGGAAGT
TCACCCACTTTTTGTCATCTCCTTCATGAAAAAGTACCATTTTGCTGCTTAAGATTAGAC
AAGAGTTGCCAACATAACTACTATGAGGATGCAAAAGCCTATGGATTCAAAAATAAACTA
ATTATAGTTGCAGCTGAAACAGCTGGAAATGGATTATATAACTTTATTGTTCCTCTCAGG
GCATATTATAGACCAAAGAAAGAACTTAATCCCATAGTACTGCTATTGGATAACCCGCCA
GATATGCATTTTCTGGATGCAATCTGTTGGTTTCCAATGGTTTACTACATGGTGGGCTCT
ATTGACAACCTAGATGACTTACTCAGGTGTGGAGTGACTTTTGCTGCTAATATGGTGGTT
GTGGATAAAGAGAGCACCATGAGTGCCGAGGAAGACTACATGGCAGATGCCAAAACCATT
GTGAACGTGCAGACACTCTTCAGGTTGTTTTCCAGTCTCAGTATTATCACAGAGCTAACT
CACCCCGCCAACATGAGATTCATGCAATTCAGAGCCAAAGACTGTTACTCTCTTGCTCTT
TCAAAACTGGAAAAGAAAGAACGGGAGAGAGGCTCTAACTTGGCCTTTATGTTTCGACTG
CCTTTTGCTGCTGGGAGGGTGTTTAGCATCAGTATGTTGGACACTCTGCTGTATCAGTCA
TTTGTGAAGGATTATATGATTTCTATCACGAGACTTCTGTTGGGACTGGACACTACACCA
GGATCTGGGTTTCTTTGTTCTATGAAAATCACTGCAGATGACTTATGGATCAGAACTTAT
GCCAGACTTTATCAGAAGTTGTGTTCTTCTACTGGAGATGTTCCCATTGGAATCTACAGG
ACTGAGTCTCAGAAACTTACTACATCTGAGTCTCAAATATCTATCAGTGTAGAAGAGTGG
GAAGACACCAAAGACTCCAAAGAACAAGGGCACCACCGCAGCAACCACCGCAACTCAACA
TCCAGTGACCAGTCGGACCATCCCTTGCTGCGGAGAAAAAGCATGCAGTGGGCCCGAAGA
CTGAGCAGAAAAGGCCCAAAACACTCTGGTAAAACAGCTGAAAAAATAACCCAGCAGCGA
CTGAACCTCTACAGGAGGTCAGAAAGACAAGAGCTTGCTGAACTTGTGAAAAATAGAATG
AAACACTTGGGTCTTTCTACAGTGGGATATGATGAAATGAATGATCATCAAAGTACCCTC
TCCTACATCCTGATTAACCCATCTCCAGATACCAGAATAGAGCTGAATGATGTTGTATAC
TTAATTCGACCAGATCCACTGGCCTACCTTCCAAACAGTGAGCCCAGTCGAAGAAACAGC
ATCTGCAATGTCACTGGTCAAGATTCTCGGGAGGAAACTCAACTTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1135 |
| Molecular Weight
| 130499.8 |
| Theoretical pI
| 7.3 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
- ["64-84", "102-122", "138-158", "165-185", "199-219", "257-277"]
|
| Protein Sequence
|
>Potassium channel subfamily T member 2
MVDLESEVPPLPPRYRFRDLLLGDQGWQNDDRVQVEFYMNENTFKERLKLFFIKNQRSSL
RIRLFNFSLKLLSCLLYIIRVLLENPSQGNEWSHIFWVNRSLPLWGLQVSVALISLFETI
LLGYLSYKGNIWEQILRIPFILEIINAVPFIISIFWPSLRNLFVPVFLNCWLAKHALENM
INDLHRAIQRTQSAMFNQVLILISTLLCLIFTCICGIQHLERIGKKLNLFDSLYFCIVTF
STVGFGDVTPETWSSKLFVVAMICVALVVLPIQFEQLAYLWMERQKSGGNYSRHRAQTEK
HVVLCVSSLKIDLLMDFLNEFYAHPRLQDYYVVILCPTEMDVQVRRVLQIPMWSQRVIYL
QGSALKDQDLLRAKMDDAEACFILSSRCEVDRTSSDHQTILRAWAVKDFAPNCPLYVQIL
KPENKFHIKFADHVVCEEEFKYAMLALNCICPATSTLITLLVHTSRGQEGQQSPEQWQKM
YGRCSGNEVYHIVLEESTFFAEYEGKSFTYASFHAHKKFGVCLIGVRREDNKNILLNPGP
RYIMNSTDICFYINITKEENSAFKNQDQQRKSNVSRSFYHGPSRLPVHSIIASMGTVAID
LQDTSCRSASGPTLSLPTEGSKEIRRPSIAPVLEVADTSSIQTCDLLSDQSEDETTPDEE
MSSNLEYAKGYPPYSPYIGSSPTFCHLLHEKVPFCCLRLDKSCQHNYYEDAKAYGFKNKL
IIVAAETAGNGLYNFIVPLRAYYRPKKELNPIVLLLDNPPDMHFLDAICWFPMVYYMVGS
IDNLDDLLRCGVTFAANMVVVDKESTMSAEEDYMADAKTIVNVQTLFRLFSSLSIITELT
HPANMRFMQFRAKDCYSLALSKLEKKERERGSNLAFMFRLPFAAGRVFSISMLDTLLYQS
FVKDYMISITRLLLGLDTTPGSGFLCSMKITADDLWIRTYARLYQKLCSSTGDVPIGIYR
TESQKLTTSESQISISVEEWEDTKDSKEQGHHRSNHRNSTSSDQSDHPLLRRKSMQWARR
LSRKGPKHSGKTAEKITQQRLNLYRRSERQELAELVKNRMKHLGLSTVGYDEMNDHQSTL
SYILINPSPDTRIELNDVVYLIRPDPLAYLPNSEPSRRNSICNVTGQDSREETQL
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q6UVM3 |
| UniProtKB/Swiss-Prot Entry Name
| KCNT2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY359444 |
| GeneCard ID
| KCNT2 |
| GenAtlas ID
| KCNT2 |
| HGNC ID
| HGNC:18866 |
| References |
|---|
| General References
| Not Available |