Showing Protein Calcium-activated potassium channel subunit beta-2 (CDBP02969)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP02969
Secondary Accession Numbers Not Available
Name Calcium-activated potassium channel subunit beta-2
Description Not Available
Synonyms
  1. BK channel subunit beta-2
  2. BKbeta2
  3. Calcium-activated potassium channel, subfamily M subunit beta-2
  4. Charybdotoxin receptor subunit beta-2
  5. Hbeta2
  6. Hbeta3
  7. K(VCA)beta-2
  8. Maxi K channel subunit beta-2
  9. Slo-beta-2
Gene Name KCNMB2
Protein Type Transporter
Biological Properties
General Function Involved in calcium-activated potassium channel activity
Specific Function Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. Acts as a negative regulator that confers rapid and complete inactivation of KCNMA1 channel complex. May participate in KCNMA1 inactivation in chromaffin cells of the adrenal gland or in hippocampal CA1 neurons
GO Classification
Component
membrane
cell part
Function
calcium activated cation channel activity
calcium-activated potassium channel activity
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
transporter activity
ion channel activity
cation channel activity
Process
transport
monovalent inorganic cation transport
potassium ion transport
ion transport
cation transport
establishment of localization
Cellular Location
  1. Membrane
  2. Multi-pass membrane protein
Pathways
Gene Properties
Chromosome Location Chromosome:3
Locus 3q26.32
SNPs KCNMB2
Gene Sequence 
>708 bp
ATGTTTATATGGACCAGTGGCCGGACCTCTTCATCTTATAGACATGATGAAAAAAGAAAT
ATTTACCAGAAAATCAGGGACCATGACCTCCTGGACAAAAGGAAAACAGTCACAGCACTG
AAGGCAGGAGAGGACCGAGCTATTCTCCTGGGACTGGCTATGATGGTGTGCTCCATCATG
ATGTATTTTCTGCTGGGAATCACACTCCTGCGCTCATACATGCAGAGCGTGTGGACCGAA
GAGTCTCAATGCACCTTGCTGAATGCGTCCATCACGGAAACATTTAACTGCTCCTTCAGC
TGTGGTCCAGACTGCTGGAAACTTTCTCAGTACCCCTGCCTCCAGGTGTACGTTAACCTG
ACTTCTTCCGGGGAAAAGCTCCTCCTCTACCACACAGAAGAGACAATAAAAATCAATCAG
AAGTGCTCCTATATACCTAAATGTGGAAAAAATTTTGAAGAATCCATGTCCCTGGTGAAT
GTTGTCATGGAAAACTTCAGGAAGTATCAACACTTCTCCTGCTATTCTGACCCAGAAGGA
AACCAGAAGAGTGTTATCCTAACCAAACTCTACAGTTCCAACGTGCTGTTCCATTCACTC
TTCTGGCCAACCTGTATGATGGCTGGGGGTGTGGCAATTGTTGCCATGGTGAAACTTACA
CAGTACCTCTCCCTACTATGTGAGAGGATCCAACGGATCAATAGATAA
Protein Properties
Number of Residues 235
Molecular Weight 27129.4
Theoretical pI 8.47
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["47-67", "195-215"]
Protein Sequence 
>Calcium-activated potassium channel subunit beta-2
MFIWTSGRTSSSYRHDEKRNIYQKIRDHDLLDKRKTVTALKAGEDRAILLGLAMMVCSIM
MYFLLGITLLRSYMQSVWTEESQCTLLNASITETFNCSFSCGPDCWKLSQYPCLQVYVNL
TSSGEKLLLYHTEETIKINQKCSYIPKCGKNFEESMSLVNVVMENFRKYQHFSCYSDPEG
NQKSVILTKLYSSNVLFHSLFWPTCMMAGGVAIVAMVKLTQYLSLLCERIQRINR
GenBank ID Protein 4566497
UniProtKB/Swiss-Prot ID Q9Y691
UniProtKB/Swiss-Prot Entry Name KCMB2_HUMAN
PDB IDs
GenBank Gene ID AF099137
GeneCard ID KCNMB2
GenAtlas ID KCNMB2
HGNC ID HGNC:6286
References
General References Not Available