| Identification |
|---|
| HMDB Protein ID
| CDBP02966 |
| Secondary Accession Numbers
| Not Available |
| Name
| Kv channel-interacting protein 2 |
| Description
| Not Available |
| Synonyms
|
- A-type potassium channel modulatory protein 2
- Cardiac voltage-gated potassium channel modulatory subunit
- KChIP2
- Potassium channel-interacting protein 2
|
| Gene Name
| KCNIP2 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Regulatory subunit of Kv4/D (Shal)-type voltage-gated rapidly inactivating A-type potassium channels. Probably modulates channels density, inactivation kinetics and rate of recovery from inactivation in a calcium-dependent and isoform-specific manner. In vitro, modulates KCND2/Kv4.2 and KCND3/Kv4.3 currents. Involved in KCND2 and KCND3 trafficking to the cell surface |
| GO Classification
|
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| calcium ion binding |
|
| Cellular Location
|
- Lipid-anchor
- Isoform 6:Cell membrane
|
| Pathways
|
| Name | SMPDB/Pathwhiz | KEGG | | Muscle/Heart Contraction |    | Not Available | | Acebutolol Action Pathway |    | Not Available | | Alprenolol Action Pathway |    | Not Available | | Atenolol Action Pathway |    | Not Available | | Betaxolol Action Pathway |    | Not Available |
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 10q24 |
| SNPs
| KCNIP2 |
| Gene Sequence
|
>813 bp
ATGCGGGGCCAGGGCCGCAAGGAGAGTTTGTCCGATTCCCGAGACCTGGACGGCTCCTAC
GACCAGCTCACGGGCCACCCTCCGGGGCCCACTAAAAAAGCGCTGAAGCAGCGGTTCCTC
AAGCTGCTGCCGTGCTGCGGGCCCCAAGTCCTGCCCTCAGTCAGTGAAACATTAGCCGCC
CCAGCCTCCCTCCGCCCCCACAGACCCCGCCCGCTGGACCCAGACAGCGTGGAGGATGAA
TTTGAACTGTCCACTGTGTGTCACCGGCCCGAGGGTCTGGAACAACTGCAGGAGCAAACC
AAGTTCACACGCAAGGAGTTGCAGGTCCTGTACCGAGGCTTCAAGAACGAGTGTCCCAGC
GGAATCGTCAATGAGGAGAACTTCAAGCAGATTTACTCCCAGTTCTTTCCTCAAGGAGAC
TCCAGCACCTACGCTACTTTTCTCTTCAATGCCTTTGACACCAACCACGACGGCTCCGTC
AGCTTCGAGGACTTTGTGGCTGGCTTGTCGGTGATTCTTCGGGGAACGGTAGATGACAGA
CTGAATTGGGCCTTCAACTTGTATGACCTCAACAAGGACGGCTGCATCACTAAGGAGGAA
ATGCTCGACATCATGAAGTCCATCTATGACATGATGGGCAAGTACACGTACCCTGCACTC
CGGGAGGAGCCCCCAAGGGAACATGTGGAGAGCTTCTTCCAGAAGATGGACAGAAACAAG
GATGGAGTGGTGACCATTGAGGAATTCATTGAGTCTTGTCAAAAGGACGAGAACATCATG
AGGTCCATGCAGCTCTTTGACAATGTCATCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 270 |
| Molecular Weight
| 30918.6 |
| Theoretical pI
| 4.73 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Kv channel-interacting protein 2
MRGQGRKESLSDSRDLDGSYDQLTGHPPGPTKKALKQRFLKLLPCCGPQVLPSVSETLAA
PASLRPHRPRPLDPDSVDDEFELSTVCHRPEGLEQLQEQTKFTRKELQVLYRGFKNECPS
GIVNEENFKQIYSQFFPQGDSSTYATFLFNAFDTNHDGSVSFEDFVAGLSVILRGTVDDR
LNWAFNLYDLNKDGCITKEEMLDIMKSIYDMMGKYTYPALREEAPREHVESFFQKMDRNK
DGVVTIEEFIESCQKDENIMRSMQLFDNVI
|
| External Links |
|---|
| GenBank ID Protein
| 9309285 |
| UniProtKB/Swiss-Prot ID
| Q9NS61 |
| UniProtKB/Swiss-Prot Entry Name
| KCIP2_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB044584 |
| GeneCard ID
| KCNIP2 |
| GenAtlas ID
| KCNIP2 |
| HGNC ID
| HGNC:15522 |
| References |
|---|
| General References
| Not Available |