| Identification |
|---|
| HMDB Protein ID
| CDBP02959 |
| Secondary Accession Numbers
| Not Available |
| Name
| Intelectin-1 |
| Description
| Not Available |
| Synonyms
|
- Endothelial lectin HL-1
- Galactofuranose-binding lectin
- ITLN-1
- Intestinal lactoferrin receptor
- Omentin
|
| Gene Name
| ITLN1 |
| Protein Type
| Receptor |
| Biological Properties |
|---|
| General Function
| Involved in receptor binding |
| Specific Function
| Has no effect on basal glucose uptake but enhances insulin-stimulated glucose uptake in adipocytes. Increases AKT phosphorylation in the absence and presence of insulin. May play a role in the defense system against microorganisms. May specifically recognize carbohydrate chains of pathogens and bacterial components containing galactofuranosyl residues, in a calcium-dependent manner. May be involved in iron metabolism |
| GO Classification
|
| Function |
| binding |
| protein binding |
| receptor binding |
| Process |
| biological regulation |
| regulation of biological process |
| regulation of cellular process |
| signal transduction |
|
| Cellular Location
|
- Cell membrane
- Lipid-anchor
- GPI-anchor
- Secreted
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1q21.3 |
| SNPs
| ITLN1 |
| Gene Sequence
|
>942 bp
ATGAACCAACTCAGCTTCCTGCTGTTTCTCATAGCGACCACCAGAGGATGGAGTACAGAT
GAGGCTAATACTTACTTCAAGGAATGGACCTGTTCTTCGTCTCCATCTCTGCCCAGAAGC
TGCAAGGAAATCAAAGACGAATGTCCTAGTGCATTTGATGGCCTGTATTTTCTCCGCACT
GAGAATGGTGTTATCTACCAGACCTTCTGTGACATGACCTCTGGGGGTGGCGGCTGGACC
CTGGTGGCCAGCGTGCATGAGAATGACATGCGTGGGAAGTGCACGGTGGGCGATCGCTGG
TCCAGTCAGCAGGGCAGCAAAGCAGACTACCCAGAGGGGGACGGCAACTGGGCCAACTAC
AACACCTTTGGATCTGCAGAGGCGGCCACGAGCGATGACTACAAGAACCCTGGCTACTAC
GACATCCAGGCCAAGGACCTGGGCATCTGGCACGTGCCCAATAAGTCCCCCATGCAGCAC
TGGAGAAACAGCTCCCTGCTGAGGTACCGCACGGACACTGGCTTCCTCCAGACACTGGGA
CATAATCTGTTTGGCATCTACCAGAAATATCCAGTGAAATATGGAGAAGGAAAGTGTTGG
ACTGACAACGGCCCGGTGATCCCTGTGGTCTATGATTTTGGCGACGCCCAGAAAACAGCA
TCTTATTACTCACCCTATGGCCAGCGGGAATTCACTGCGGGATTTGTTCAGTTCAGGGTA
TTTAATAACGAGAGAGCAGCCAACGCCTTGTGTGCTGGAATGAGGGTCACCGGATGTAAC
ACTGAGCACCACTGCATTGGTGGAGGAGGATACTTTCCAGAGGCCAGTCCCCAGCAGTGT
GGAGATTTTTCTGGTTTTGATTGGAGTGGATATGGAACTCATGTTGGTTACAGCAGCAGC
CGTGAGATAACTGAGGCAGCTGTGCTTCTATTCTATCGTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 313 |
| Molecular Weight
| 34961.5 |
| Theoretical pI
| 5.89 |
| Pfam Domain Function
|
Not Available |
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Intelectin-1
MNQLSFLLFLIATTRGWSTDEANTYFKEWTCSSSPSLPRSCKEIKDECPSAFDGLYFLRT
ENGVIYQTFCDMTSGGGGWTLVASVHENDMRGKCTVGDRWSSQQGSKAVYPEGDGNWANY
NTFGSAEAATSDDYKNPGYYDIQAKDLGIWHVPNKSPMQHWRNSSLLRYRTDTGFLQTLG
HNLFGIYQKYPVKYGEGKCWTDNGPVIPVVYDFGDAQKTASYYSPYGQREFTAGFVQFRV
FNNERAANALCAGMRVTGCNTEHHCIGGGGYFPEASPQQCGDFSGFDWSGYGTHVGYSSS
REITEAAVLLFYR
|
| External Links |
|---|
| GenBank ID Protein
| 8096221 |
| UniProtKB/Swiss-Prot ID
| Q8WWA0 |
| UniProtKB/Swiss-Prot Entry Name
| ITLN1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB036706 |
| GeneCard ID
| ITLN1 |
| GenAtlas ID
| ITLN1 |
| HGNC ID
| HGNC:18259 |
| References |
|---|
| General References
| Not Available |