| Identification |
|---|
| HMDB Protein ID
| CDBP02956 |
| Secondary Accession Numbers
| Not Available |
| Name
| Inversin |
| Description
| Not Available |
| Synonyms
|
- Inversion of embryo turning homolog
- Nephrocystin-2
|
| Gene Name
| INVS |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in calmodulin binding |
| Specific Function
| Required for normal renal development and establishment of left-right axis. Probably acts as a molecular switch between different Wnt signaling pathways. Inhibits the canonical Wnt pathway by targeting cytoplasmic disheveled (DVL1) for degradation by the ubiquitin-proteasome. This suggests that it is required in renal development to oppose the repression of terminal differentiation of tubular epithelial cells by Wnt signaling |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Nucleus
- Cytoplasm
- Cytoplasm
- Cytoplasm
- Peripheral membrane protein
- Membrane
- cytoskeleton
- cytoskeleton
- spindle
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:9 |
| Locus
| 9q31 |
| SNPs
| INVS |
| Gene Sequence
|
>3198 bp
ATGAACAAGTCAGAGAACCTGCTGTTTGCTGGTTCATCATTAGCATCACAAGTCCATGCT
GCTGCCGTTAATGGAGATAAGGGTGCTCTACAGAGGCTCATCGTAGGAAACTCTGCTCTT
AAAGACAAAGAAGATCAGTTTGGGAGAACACCACTTATGTATTGCGTGTTGGCTGACAGA
TTGGATTGTGCAGATGCTCTTCTGAAGGCAGGAGCAGATGTGAATAAAACTGACCATAGC
CAGAGAACAGCCCTCCATCTTGCAGCCCAGAAGGGAAATTATCGTTTCATGAAACTCTTA
CTTACACGCAGAGCAAACTGGATGCAAAAGGATCTGGAAGAGATGACTCCTTTGCACTTG
ACCACCCGGCACAGGAGCCCTAAGTGTTTGGCACTTCTGCTGAAGTTTATGGCACCAGGA
GAAGTGGATACACAGGATAAAAACAAGCAAACAGCTCTGCATTGGAGTGCCTACTACAAT
AACCCTGAGCATGTGAAGCTGCTCATCAAGCATGATTCTAACATTGGGATTCCTGATGTT
GAAGGCAAGATCCCACTTCACTGGGCAGCCAACCATAAAGATCCAAGTGCTGTTCACACA
GTGAGATGCATTCTGGATGCTGCTCCAACAGAGTCTTTACTGAACTGGCAAGACTACGAG
GGTCGAACTCCTCTTCACTTTGCAGTTGCTGATGGGAATGTGACCGTGGTTGATGTCTTG
ACCTCATATGAAAGCTGCAATATAACGTCTTATGATAACTTATTTCGAACCCCACTGCAC
TGGGCAGCTTTATTAGGCCATGCACAGATTGTCCATCTCCTTTTAGAAAGAAATAAGTCT
GGAACTATCCCATCTGACAGCCAAGGAGCCACACCTTTGCACTATGCTGCTCAGAGTAAC
TTTGCTGAAACGGTTAAAGTGTTTTTAAAACATCCTTCAGTGAAAGATGATTCAGACCTG
GAAGGAAGAACATCCTTTATGTGGGCAGCTGGCAAAGGCAGTGATGATGTCCTTAGAACT
ATGCTGAGCTTAAAATCGGACATAGATATTAACATGGCTGACAAATATGGAGGTACAGCT
TTGCATGCTGCTGCTCTTTCTGGCCATGTCAGCACCGTGAAGTTATTACTGGAAAATAAT
GCTCAAGTAGATGCTACTGATGTTATGAAACATACTCCACTTTTCCGAGCCTGTGAGATG
GGACACAAAGATGTGATTCAGACACTCATTAAAGGTGGAGCAAGGGTAGATCTAGTTGAC
CAAGATGGACATTCTCTTCTACATTGGGCAGCACTGGGAGGAAATGCTGATGTTTGCCAG
ATATTAATAGAAAATAAGATCAATCCAAATGTCCAGGATTATGCAGGAAGAACCCCTTTG
CAGTGTGCAGCATATGGAGGCTATATCAACTGCATGGCAGTTCTCATGGAAAACAATGCA
GACCCTAACATTCAAGACAAAGAGGGAAGAACAGCTTTGCATTGGTCCTGCAACAATGGA
TACCTTGATGCCATTAAATTACTGCTAGACTTTGCTGCTTTCCCTAATCAGATGGAAAAC
AATGAAGAGAGATACACACCCCTTGATTATGCTTTGCTTGGTGAGCGCCATGAAGTGATC
CAGTTCATGTTGGAGCACGGTGCCCTGTCCATCGCAGCCATACAAGACATCGCCGCCTTC
AAAATCCAAGCTGTCTACAAAGGGTACAAGGTCAGAAAAGCCTTCCGAGACAGGAAAAAT
CTCCTCATGAAGCATGAACAGTTGAGAAAAGATGCTGCTGCCAAAAAGCGAGAGGAAGAA
AACAAACGAAAAGAGGCAGAACAGCAAAAAGGAAGGCGGAGCCCAGATTCCTGCAGACCC
CAGGCCCTTCCCTGTCTGCCTAGCACCCAGGATGTGCCCAGCAGGCAGAGCCGGGCCCCC
AGCAAGCAGCCTCCTGCTGGCAACGTGGCCCAAGGCCCTGAGCCAAGAGACAGCAGAGGA
TCTCCAGGAGGGTCTCTAGGCGGAGCCCTCCAGAAGGAGCAGCATGTTTCCTCAGATTTG
CAGGGAACAAACTCCAGAAGGCCAAATGAAACAGCCAGAGAACATTCTAAAGGCCAATCT
GCTTGTGTCCACTTCAGACCCAATGAAGGCAGTGATGGAAGCAGGCATCCAGGAGTTCCC
TCTGTTGAGAAGTCCAGAGGTGAGACAGCTGGCGATGAGCGGTGTGCAAAGGGGAAAGGC
TTCGTGAAGCAGCCCTCCTGTATCAGGGTGGCTGGGCCTGATGAGAAAGGAGAGGACTCC
AGGCGGGCAGCTGCAAGCCTTCCACCGCACGATAGCCACTGGAAGCCCAGCAGGCGGCAT
GACACAGAACCCAAGGCCAAATGTGCCCCCCAGAAAAGGCGCACTCAAGAGCTCAGAGGA
GGAAGGTGCTCTCCGGCTGGTTCTAGCCGCCCTGGCAGTGCCCGGGGGGAGGCGGTCCAT
GCTGGGCAGAATCCTCCCCACCATCGTACACCAAGAAACAAAGTGACACAAGCCAAGCTC
ACAGGAGGGCTCTATTCACATTTGCCACAGAGCACAGAGGAGTTGAGGTCAGGAGCTAGG
AGGCTGGAGACATCTACCCTGTCCGAGGACTTTCAGGTATCTAAGGAGACTGATCCAGCA
CCTGGTCCCCTCTCTGGGCAGAGTGTGAATATTGACCTTCTCCCCGTAGAGCTCCGACTG
CAGATAATTCAGAGAGAACGAAGGAGGAAGGAGCTGTTTCGCAAAAAGAACAAGGCAGCA
GCAGTCATCCAGCGCGCCTGGCGAAGCTACCAGCTCAGGAAGCACCTGTCCCACCTTCGG
CATATGAAGCAGCTTGGAGCTGGAGATGTGGACAGATGGAGGCAAGAGTCTACAGCATTG
CTCCTCCAGGTTTGGAGGAAGGAACTGGAACTAAAATTCCCCCAAACCACTGCAGTAAGC
AAGGCCCCCAAGAGTCCATCCAAGGGCACCTCAGGCACAAAGTCCACCAAGCACTCAGTG
CTTAAGCAAATCTATGGTTGTTCTCACGAAGGGAAAATACATCATCCTACAAGATCTGTA
AAAGCCTCTTCTGTGCTGCGTCTCAACTCAGTGAGCAACCTACAGTGTATACATCTCCTT
GAGAACAGTGGAAGATCAAAGAACTTTTCTTATAACCTGCAATCAGCTACTCAGCCAAAA
AACAAAACAAAACCTTGA
|
| Protein Properties |
|---|
| Number of Residues
| 1065 |
| Molecular Weight
| 117825.4 |
| Theoretical pI
| 9.89 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Inversin
MNKSENLLFAGSSLASQVHAAAVNGDKGALQRLIVGNSALKDKEDQFGRTPLMYCVLADR
LDCADALLKAGADVNKTDHSQRTALHLAAQKGNYRFMKLLLTRRANWMQKDLEEMTPLHL
TTRHRSPKCLALLLKFMAPGEVDTQDKNKQTALHWSAYYNNPEHVKLLIKHDSNIGIPDV
EGKIPLHWAANHKDPSAVHTVRCILDAAPTESLLNWQDYEGRTPLHFAVADGNVTVVDVL
TSYESCNITSYDNLFRTPLHWAALLGHAQIVHLLLERNKSGTIPSDSQGATPLHYAAQSN
FAETVKVFLKHPSVKDDSDLEGRTSFMWAAGKGSDDVLRTMLSLKSDIDINMADKYGGTA
LHAAALSGHVSTVKLLLENNAQVDATDVMKHTPLFRACEMGHKDVIQTLIKGGARVDLVD
QDGHSLLHWAALGGNADVCQILIENKINPNVQDYAGRTPLQCAAYGGYINCMAVLMENNA
DPNIQDKEGRTALHWSCNNGYLDAIKLLLDFAAFPNQMENNEERYTPLDYALLGERHEVI
QFMLEHGALSIAAIQDIAAFKIQAVYKGYKVRKAFRDRKNLLMKHEQLRKDAAAKKREEE
NKRKEAEQQKGRRSPDSCRPQALPCLPSTQDVPSRQSRAPSKQPPAGNVAQGPEPRDSRG
SPGGSLGGALQKEQHVSSDLQGTNSRRPNETAREHSKGQSACVHFRPNEGSDGSRHPGVP
SVEKSRGETAGDERCAKGKGFVKQPSCIRVAGPDEKGEDSRRAAASLPPHDSHWKPSRRH
DTEPKAKCAPQKRRTQELRGGRCSPAGSSRPGSARGEAVHAGQNPPHHRTPRNKVTQAKL
TGGLYSHLPQSTEELRSGARRLETSTLSEDFQVSKETDPAPGPLSGQSVNIDLLPVELRL
QIIQRERRRKELFRKKNKAAAVIQRAWRSYQLRKHLSHLRHMKQLGAGDVDRWRQESTAL
LLQVWRKELELKFPQTTAVSKAPKSPSKGTSGTKSTKHSVLKQIYGCSHEGKIHHPTRSV
KASSVLRLNSVSNLQCIHLLENSGRSKNFSYNLQSATQPKNKTKP
|
| External Links |
|---|
| GenBank ID Protein
| 34304381 |
| UniProtKB/Swiss-Prot ID
| Q9Y283 |
| UniProtKB/Swiss-Prot Entry Name
| INVS_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_014425.2 |
| GeneCard ID
| INVS |
| GenAtlas ID
| INVS |
| HGNC ID
| HGNC:17870 |
| References |
|---|
| General References
| Not Available |