| Identification |
|---|
| HMDB Protein ID
| CDBP02955 |
| Secondary Accession Numbers
| Not Available |
| Name
| Immunoglobulin superfamily member 5 |
| Description
| Not Available |
| Synonyms
|
- IgSF5
- JAM-4
- Junctional adhesion molecule 4
|
| Gene Name
| IGSF5 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Provides, together with MAGI1, an adhesion machinery at tight junctions, which may regulate the permeability of kidney glomerulus and small intestinal epithelial cells. Mediates calcium-independent homophilic cell adhesion. In testis, it may function as a cell adhesion molecule rather than a tight-junction protein. It may participate in the adhesion between spermatogonia- spermatogonia, spermatogonia-Sertoli cells, and Sertoli cells- Sertoli cells |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Cell membrane
- Single-pass membrane protein
- Cell junction
- tight junction
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:2 |
| Locus
| 21q22.2 |
| SNPs
| IGSF5 |
| Gene Sequence
|
>1224 bp
ATGGGTCAGAAGGAAAGGAGCACAGCAGATACTCTGCCGGATCTGGAGGAATGGAAGTCA
GCGGCGGGTCTGCGATGGTGGCAAACAGCAGTGGTGGACGGTTCTGGGTCTGGTAATGAA
GTCATAGAAGGCCCCCAGAATGCAACAGTCCTGAAGGGCTCCCAGGCTCGCTTCAACTGC
ACCGTCTCCCAGGGCTGGAAGCTCATCATGTGGGCTCTCAGTGACATGGTGGTGCTAAGC
GTCAGGCCCATGGAGCCCATCATCACCAATGACCGCTTCACCTCTCAGAGGTACGACCAG
GGCGGGAACTTCACCTCGGAGATGATCATCCACAATGTGGAGCCCAGTGATTCGGGGAAC
ATCAGATGCAGCCTCCAGAACAGTCGCCTGCATGGATCTGCTTACCTTACCGTCCAAGTT
ATGGGAGAGCTGTTCATTCCCAGTGTTAATCTTGTAGTCGCTGAGAATGAACCTTGTGAA
GTTACTTGTCTACCCTCACACTGGACCCGGCTCCCGGATATTTCCTGGGAGCTCGGTCTC
CTGGTCAGCCATTCAAGCTATTATTTTGTTCCGGAGCCCAGCGACCTTCAAAGTGCAGTG
AGCATCCTGGCTCTGACCCCACAGAGCAATGGGACTTTGACTTGCGTGGCTACCTGGAAG
AGCCTGAAGGCCCGCAAGTCTGCAACTGTAAATCTCACTGTGATTCGGTGTCCCCAAGAC
ACTGGAGGTGGTATTAATATTCCAGGTGTATTATCAAGTTTACCGAGTTTAGGTTTTTCA
TTGCCTACTTGGGGCAAAGTTGGACTTGGACTAGCAGGCACCATGCTTCTGACGCCGACG
TGTACTCTTACAATACGCTGCTGCTGCTGCCGCCGTCGTTGTTGTGGCTGCAACTGCTGC
TGCCGTTGTTGTTTCTGCTGTAGAAGAAAAAGAGGATTTCGTATTCAATTTCAAAAGAAA
TCTGAAAAAGAGAAGACAAACAAAGAAACTGAGACAGAAAGTGGAAATGAAAACTCCGGC
TACAATTCAGATGAACAAAAGACCACAGAAACCGCTTCTCTCCCTCCCAAATCCTGTGAA
TCCAGTGATCCTGAACAAAGAAACAGTAGCTGTGGCCCTCCTCACCAGCGGGCTGATCAA
CGTCCACCCAGGCCAGCAAGTCATCCACAGGCTTCTTTTAATCTGGCCAGTCCTGAGAAG
GTCAGTAATACAACTGTAGTATAG
|
| Protein Properties |
|---|
| Number of Residues
| 407 |
| Molecular Weight
| 44592.2 |
| Theoretical pI
| 7.83 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Immunoglobulin superfamily member 5
MGQKERSTADTLPDLEEWKSAAGLRWWQTAVVDGSGSGNEVIEGPQNARVLKGSQARFNC
TVSQGWKLIMWALSDMVVLSVRPMEPIITNDRFTSQRYDQGGNFTSEMIIHNVEPSDSGN
IRCSLQNSRLHGSAYLTVQVMGELFIPSVNLVVAENEPCEVTCLPSHWTRLPDISWELGL
LVSHSSYYFVPEPSDLQSAVSILALTPQSNGTLTCVATWKSLKARKSATVNLTVIRCPQD
TGGGINIPGVLSSLPSLGFSLPTWGKVGLGLAGTMLLTPTCTLTIRCCCCRRRCCGCNCC
CRCCFCCRRKRGFRIQFQKKSEKEKTNKETETESGNENSGYNSDEQKTTDTASLPPKSCE
SSDPEQRNSSCGPPHQRADQRPPRPASHPQASFNLASPEKVSNTTVV
|
| External Links |
|---|
| GenBank ID Protein
| 193787359 |
| UniProtKB/Swiss-Prot ID
| Q9NSI5 |
| UniProtKB/Swiss-Prot Entry Name
| IGSF5_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AK092516 |
| GeneCard ID
| IGSF5 |
| GenAtlas ID
| IGSF5 |
| HGNC ID
| HGNC:5952 |
| References |
|---|
| General References
| Not Available |