Cannabis Compound Database: Showing Protein Immunoglobulin superfamily member 2 (CDBP02954)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP02954

Secondary Accession Numbers

Not Available

Name

Immunoglobulin superfamily member 2

Description

Not Available

Synonyms

CD101 antigen
Cell surface glycoprotein V7
EWI-101
Glu-Trp-Ile EWI motif-containing protein 101
IgSF2

Gene Name

CD101

Protein Type

Enzyme

Biological Properties

General Function

Involved in hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

Specific Function

Plays a role as inhibitor of T-cells proliferation induced by CD3. Inhibits expression of IL2RA on activated T-cells and secretion of IL2. Inhibits tyrosine kinases that are required for IL2 production and cellular proliferation. Inhibits phospholipase C-gamma-1/PLCG1 phosphorylation and subsequent CD3- induced changes in intracellular free calcium. Prevents nuclear translocation of nuclear factor of activated T-cell to the nucleus. Plays a role in the inhibition of T-cell proliferation via IL10 secretion by cutaneous dendritic cells. May be a marker of CD4(+) CD56(+) leukemic tumor cells

GO Classification

Function
catalytic activity
hydrolase activity
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds
hydrolase activity, acting on carbon-nitrogen (but not peptide) bonds, in cyclic amides

Cellular Location

Membrane
Single-pass type I membrane protein (Potential)

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:1

Locus

1p13

SNPs

CD101

Gene Sequence

>3066 bp
ATGGCAGGCATCTCATATGTGGCATCTTTCTTTCTCCTTCTGACTAAGCTCAGCATTGGC
CAGAGAGAAGTAACAGTTCAGAAAGGACCACTGTTTAGAGCTGAAGGTTACCCAGTCAGC
ATTGGCTGCAATGTAACTGGCCACCAGGGACCTTCTGAGCAGCATTTCCAGTGGTCTGTT
TACCTGCCGACAAACCCGACCCAGGAAGTCCAGATCATTAGCACCAAGGATGCTGCCTTC
TCTTACGCAGTATATACGCAGCGGGTGCGAAGCGGAGACGTCTACGTGGAGAGGGTCCAG
GGCAACTCAGTCTTGTTGCACATCTCAAAACTCCAGATGAAGGATGCTGGCGAGTATGAG
TGTCACACACCAAACACTGATGAGAAATACTATGGAAGTTACAGTGCAAAGACTAATCTA
ATTGTTATTCCAGATACCCTCTCTGCCACCATGAGTTCTCAGACTCTCGGTAAGGAGGAA
GGTGAGCCATTAGCCCTCACCTGTGAGGCATCCAAAGCCACAGCCCAACATACTCACCTC
TCTGTCACCTGGTACCTAACACAGGATGGAGGAGGAAGCCAAGCCACTGAGATTATTTCT
CTCTCCAAAGATTTTATATTGGTCCCTGGGCCCTTGTATACAGAGCGGTTTGCAGCCAGT
GACGTACAGCTCAACAAACTGGGACCCACTACATTCAGGCTGTCCATAGAGAGGCTCCAG
TCCTCAGATCAGGGTCAGCTGTTCTGTGAGGCAACGGAATGGATTCAGGATCCAGATGAA
ACTTGGATGTTCATCACCAAAAAGCAGACCGATCAAACCACTCTGAGGATCCAGCCAGCA
GTGAAAGATTTTCAAGTCAACATTACAGCTGACAGCTTGTTTGCTGAAGGGAAACCCTTA
GAACTGGTTTGCCTGGTTGTAAGCAGTGGCCGTGACCCACAGCTTCAAGGCATTTGGTTC
TTCAATGGGACTGAAATTGCTCACATTGATGCTGGTGGAGTCCTGGGCCTGAAGAATGAC
TACAAAGAGAGAGCAAGTCAAGGAGAGCTCCAGGTTTCAAAGTTAGGCCCCAAGGCTTTC
TCTCTCAAGATCTTCTCTCTGGGCCCAGAGGATGAAGGCGCCTACAGATGTGTGGTAGCA
GAGGTCATGAAAACACGCACAGGTTCCTGGCAGGTGCTTCAGAGAAAGCAGTCACCAGAC
AGCCACGTGCACCTGAGGAAGCCAGCAGCAAGAAGTGTGGTCATGTCTACCAAGAACAAG
CAGCAAGTTGTGTGGGAAGGAGAGACACTCGCCTTTCTCTGTAAGGCTGGTGGAGCTGAA
AGTCCCCTGTCTGTGAGCTGGTGGCACATCCCACGGGACCAGACACAGCCCGAGTTTGTG
GCTGGCATGGGGCAGGATGGCATTGTGCAGCTGGGTGCCTCCTATGGGGTACCCAGTTAC
CATGGCAACACAAGGCTGGAGAAAATGGACTGGGCCACCTTCCAGCTGGAGATCACCTTC
ACTGCCATCACAGACAGTGGCACATATGAGTGCAGAGTATCTGAGAAGTCTCGGAACCAG
GCCAGAGATCTGAGCTGGACTCAGAAGATTTCAGTTACTGTAAAGTCTCTGGAGTCAAGT
TTACAAGTTAGTCTGATGAGCCGTCAGCCGCAAGTGATGTTAACCAACACCTTTGACCTG
TCCTGTGTCGTGAGGGCCGGTTACTCTGACCTCAAGGTGCCACTCACTGTGACGTGGCAG
TTCCAGCCAGCTAGCTCTCACATCTTCCACCAGCTTATTCGAATCACCCACAATGGCACT
ATTGAATGGGGGAATTTCCTATCCCGGTTCCAAAAGAAGACGAAAGTGTCGCAGTCTTTA
TTTCGTTCACAACTCCTAGTCCATGATGCCACTGAGGAAGAGACAGGAGTGTATCAGTGT
GAAGTAGAAGTTTATGACAGAAATTCCCTATACAACAACCGCCCCCCGAGGGCTTCTGCC
ATCTCTCACCCACTGAGGATAGCCGTCACTTTACCAGAGAGCAAGCTAAAAGTGAATTCA
AGGAGTCAAGTCCAAGAGCTCTCCATCAACTCCAACACTGATATAGAATGTAGCATCTTG
TCCCGGTCCAATGGAAACCTTCAGTTAGCCATTATTTGGTATTTTTCTCCTGTTTCCACT
AATGCCTCTTGGCTAAAGATCCTGGAGATGGACCAAACCAATGTTATAAAAACTGGGGAT
GAGTTTCACACCCCACAGAGAAAACAAAAATTTCATACTGAGAAGGTTTCCCAAGACTTA
TTTCAGCTGCACATTCTGAATGTGGAAGACAGCGATCGGGGCAAATATCACTGTGCTGTG
GAGGAATGGCTCCTGTCTACAAATGGCACTTGGCACAAGCTTGGAGAAAAGAAGTCAGGA
CTAACAGAATTGAAACTCAAGCCCACAGGAAGTAAGGTACGTGTCTCCAAAGTGTACTGG
ACCGAAAATGTGACTGAGCACAGAGAAGTGGCCATCCGCTGCAGCCTGGAGAGTGTAGGC
AGCTCAGCCACTCTGTACTCTGTGATGTGGTACTGGAACAGAGAAAACTCTGGAAGTAAA
TTGCTGGTGCACTTGCAACATGATGGCTTGCTGGAGTATGGGGAAGAGGGGCTCAGGAGG
CACCTGCACTGTTACCGTTCATCCTCTACAGACTTTGTCCTGAAGCTTCATCAGGTGGAG
ATGGAGGATGCAGGAATGTACTGGTGTAGGGTGGCAGAGTGGCAGCTCCATGGACACCCA
AGCAAGTGGATTAATCAAGCATCCGATGAGTCACAGCGGATGGTGCTCACGGTGCTGCCT
TCAGAGCCCACGCTTCCTTCCAGGATCTGCTCCTCGGCCCCTTTACTCTATTTCCTGTTC
ATCTGTCCCTTCGTCCTGCTCCTCCTTCTGCTCATCTCCCTCCTCTGCTTATACTGGAAG
GCCAGGAAGTTGTCAACACTGCGTTCCAACACACGGAAAGAAAAAGCTCTCTGGGTGGAC
TTGAAAGAGGCTGGAGGTGTGACCACAAATAGGAGGGAAGACGAGGAGGAAGATGAAGGC
AACTGA

Protein Properties

Number of Residues

1021

Molecular Weight

115107.7

Theoretical pI

6.96

Pfam Domain Function

I-set (PF07679 )
V-set (PF07686 )

Signals

["1-20"]

Transmembrane Regions

["955-975"]

Protein Sequence

>Immunoglobulin superfamily member 2
MAGISYVASFFLLLTKLSIGQREVTVQKGPLFRAEGYPVSIGCNVTGHQGPSEQHFQWSV
YLPTNPTQEVQIISTKDAAFSYAVYTQRVRSGDVYVERVQGNSVLLHISKLQMKDAGEYE
CHTPNTDEKYYGSYSAKTNLIVIPDTLSATMSSQTLGKEEGEPLALTCEASKATAQHTHL
SVTWYLTQDGGGSQATEIISLSKDFILVPGPLYTERFAASDVQLNKLGPTTFRLSIERLQ
SSDQGQLFCEATEWIQDPDETWMFITKKQTDQTTLRIQPAVKDFQVNITADSLFAEGKPL
ELVCLVVSSGRDPQLQGIWFFNGTEIAHIDAGGVLGLKNDYKERASQGELQVSKLGPKAF
SLKIFSLGPEDEGAYRCVVAEVMKTRTGSWQVLQRKQSPDSHVHLRKPAARSVVMSTKNK
QQVVWEGETLAFLCKAGGAESPLSVSWWHIPRDQTQPEFVAGMGQDGIVQLGASYGVPSY
HGNTRLEKMDWATFQLEITFTAITDSGTYECRVSEKSRNQARDLSWTQKISVTVKSLESS
LQVSLMSRQPQVMLTNTFDLSCVVRAGYSDLKVPLTVTWQFQPASSHIFHQLIRITHNGT
IEWGNFLSRFQKKTKVSQSLFRSQLLVHDATEEETGVYQCEVEVYDRNSLYNNRPPRASA
ISHPLRIAVTLPESKLKVNSRSQVQELSINSNTDIECSILSRSNGNLQLAIIWYFSPVST
NASWLKILEMDQTNVIKTGDEFHTPQRKQKFHTEKVSQDLFQLHILNVEDSDRGKYHCAV
EEWLLSTNGTWHKLGEKKSGLTELKLKPTGSKVRVSKVYWTENVTEHREVAIRCSLESVG
SSATLYSVMWYWNRENSGSKLLVHLQHDGLLEYGEEGLRRHLHCYRSSSTDFVLKLHQVE
MEDAGMYWCRVAEWQLHGHPSKWINQASDESQRMVLTVLPSEPTLPSRICSSAPLLYFLF
ICPFVLLLLLLISLLCLYWKARKLSTLRSNTRKEKALWVDLKEAGGVTTNRREDEEEDEG
N

External Links

GenBank ID Protein

55665019

UniProtKB/Swiss-Prot ID

Q93033

UniProtKB/Swiss-Prot Entry Name

IGSF2_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AL445231

GeneCard ID