| Identification |
|---|
| HMDB Protein ID
| CDBP02952 |
| Secondary Accession Numbers
| Not Available |
| Name
| Inhibitor of Bruton tyrosine kinase |
| Description
| Not Available |
| Synonyms
|
- IBtk
|
| Gene Name
| IBTK |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein binding |
| Specific Function
| Acts as an inhibitor of BTK tyrosine kinase activity, thereby playing a role in B-cell development. Down-regulates BTK kinase activity, leading to interference with BTK-mediated calcium mobilization and NF-kappa-B-driven transcription |
| GO Classification
|
| Function |
| binding |
| protein binding |
|
| Cellular Location
|
- Isoform 2:Nucleus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:6 |
| Locus
| 6q14.1 |
| SNPs
| IBTK |
| Gene Sequence
|
>4062 bp
ATGAGTTCACCCATGCCTGACTGCACATCAAAGTGTCGATCCCTGAAGCATGCTTTGGAT
GTCCTTTCTGTGGTAACAAAGGGGAGCGAAAACCAGATTAAGGCCTTTCTCTCCAGTCAT
TGTTACAATGCTGCAACTATCAAGGATGTTTTTGGCAGGAATGCCCTCCACCTTGTTTCC
TCCTGTGGAAAGAAAGGAGTGTTAGATTGGCTTATTCAGAAAGGAGTGGATCTGTTGGTG
AAAGACAAAGAGTCTGGATGGACAGCATTGCACAGAAGCATTTTTTATGGACATATTGAT
TGTGTTTGGTCTCTATTGAAGCATGGTGTTAGTCTGTATATTCAAGATAAAGAAGGCTTG
TCAGCTTTGGATCTTGTAATGAAGGATAGACCAACTCATGTAGTATTCAAGAATACTGAT
CCTACAGATGTTTATACTTGGGGCGATAATACAAATTTTACCCTGGGTCATGGAAGCCAG
AATAGCAAACATCATCCAGAGTTGGTGGATCTGTTCTCCAGGAGTGGGATTTATATCAAG
CAGGTGGTGCTTTGTAAATTTCACTCCGTGTTTCTGTCTCAGAAAGGGCAGGTTTATACC
TGTGGTCATGGTCCTGGAGGGCGATTAGGACATGGAGATGAACAGACATGCTTGGTCCCT
CGGCTTGTGGAAGGACTGAATGGTCATAATTGTTCCCAAGTGGCAGCTGCTAAGGATCAT
ACTGTTGTATTAACTGAAGATGGATGTGTTTATACATTTGGTCTAAACATTTTTCATCAA
TTAGGAATTATTCCACCGCCTTCCAGTTGTAATGTACCCAGACAGATACAGGCAAAATAT
CTGAAAGGAAGGACAATCATTGGCGTTGCAGCAGGCAGGTTTCATACAGTCCTATGGACT
AGAGAAGCTGTTTACACTATGGGACTAAATGGTGGACAACTGGGTTGTTTGCTAGATCCC
AATGGAGAAAAGTGTGTAACTGCTCCTCGTCAGGTCTCTGCCCTTCACCATAAAGACATT
GCTCTGTCTTTGGTTGCTGCAAGTGATGGAGCTACAGTCTGTGTTACCACAAGGGGAGAT
ATTTACTTACTTGCAGACTATCAGTGCAAGAAGATGGCTTCTAAACAGTTGAACTTGAAA
AAAGTTCTTGTGTCTGGGGGTCATATGGAATACAAGGTTGATCCTGAACATTTGAAAGAA
AATGGGGGTCAAAAAATTTGCATTCTTGCAATGGATGGAGCTGGAAGGGTGTTTTGCTGG
AGATCAGTCAACAGTTCTCTGAAGCAGTGTCGATGGGCCTATCCACGTCAGGTCTTCATT
TCTGATATTGCTTTAAATAGAAATGAAATTCTATTTGTTACGCAAGATGGAGAAGGATTT
AGAGGGAGATGGTTTGAAGAGAAAAGAAAGAGTTCTGAAAAGAAAGAGATTTTATCAAAC
CTTCACAATTCCTCATCAGATGTGTCTTATGTCTCTGATATAAATAGTGTGTATGAAAGA
ATTCGACTTGAGAAACTTACCTTTGCACATAGAGCTGTTAGTGTCAGCACAGATCCAAGT
GGATGCAACTTTGCAATCCTGCAGTCAGATCCTAAAACAAGCCTTTATGAAATTCCAGCT
GTGTCCTCATCATCCTTTTTTGAAGAGTTTGGCAAACTGTTGAGGGAAGCAGATGAAATG
GACAGCATTCATGATGTGACATTTCAAGTTGGCAATAGACTCTTCCCTGCACATAAATAT
ATTTTGGCAGTGCATTCTGATTTTTTTCAGAAATTGTTTCTTTCAGATGGTAATACTTCA
GAATTTACAGATATTTACCAGAAAGATGAAGATTCTGCAGGGTGCCATCTCTTTGTGGTA
GAGAAGGTTCATCCTGACATGTTTGAATACCTTTTACAATTTATATACACAGATACTTGT
GACTTTTTAACTCATGGCTTCAAACCAAGAATACACTTAAACAAAAACCCAGAAGAATAT
CAGGGAACTCTGAATTCTCATTTGAATAAAGTGAATTTCCATGAAGATGATAACCAGAAG
TCTGCATTTGAAGTTTACAAAAGTAATCAAGCTCAAACAGTTAGTGAGAGGCAGAAGAGC
AAACCTAAATCTTGTAAAAAAGGAAAAAATATTAGGGAAGATGATCCTGTAAGAATGTTG
CAAACTGTTGCAAAGAAATTCGACTTCAGTAATTTGAGTAGTAGGTTAGATGGAGTCAGA
TTTGAAAATGAAAAAATTAATGTTATTGCCAAGAACACTGGTAATAAACTGAAGCTAAGT
CAGAAAAAATGTTCATTTCTGTGTGACGTGACCATGAAATCAGTGGATGGAAAGGAATTT
CCTTGTCATAAATGTGTTCTTTGTGCTAGACTTGAATATTTTCATAGTATGCTGAGTAGC
TCATGGATTGAGGCTTCCAGTTGTGCAGCTCTGGAAATGCCAATACATTCTGATATATTA
AAAGTTATTTTGGACTACCTCTATACTGATGAAGCTGTGGTGATAAAAGAATCTCAAAAT
GTAGATTTTATTTGTAGTGTTCTTGTGGTGGCTGATCAACTTCTCATAACCCGGTTGAAA
GAGATTTGTGAAGTAGCATTAACTGAAAAACTTACCCTGAAGAATGCTGCTATGCTACTG
GAATTTGCAGCAATGTATAGTGCAAAACAGTTGAAACTGTCTTGTTTACAGTTTATAGGA
TTGAATATGGCAGCTTTACTTGAAGCAAGGTCTCTTGATGTTTTAAGCGATGGTGTTTTG
AAGGATCTTTCTGAGTTTTACCGGAAAATGATTCCAGCAATGGATAGAAGAGTCATTACA
CCATATCAAGATGGACCAGATATTAGCTATTTGGAAGTAGAAGATGGAGATATCTTCTTG
AAAGAAGAAATAAATATGGAACAAAATCATTCGGAAACTATGTTCAAGAAAGCAAAAACA
AAAGCTAAAAAGAAGCCACGTAAACGTTCAGATAGTTCTGGAGGTTATAACCTTTCAGAT
ATTATTCAGAGTCCATCATCTACAGGATTATTAAAGTCTGGTAAGACCAATTCTGTGGAA
TCTCTTCCAGAACTGTTGACATCAGACTCTGAAGGAAGCTATGCAGGAGTGGGTAGTCCT
AGAGATTTACAGTCCCCTGATTTCACAACAGGATTTCATTCAGATAAGATTGAGGCGAAA
GTCAAACCGTATGTTAATGGTACATCTCCTGTGTATTCTAGGGAAGATTTAAAACCATGG
GAAAAGTCACCAATACTTAAAATATCTGCTCCACAGCCTATTCCCAGTAACAGAATTGAT
ACTACCAGCTCTGCCAGTTGGGTTGCTGGTTCTTTCAGTCCTGTCAGCCCTCCTGTTGTG
GATCTCAGAACTATCATGGAAATAGAAGAAAGTAGACAAAAATGTGGAGCTACACCAAAG
TCACATTTAGGCAAAACAGTTTCTCATGGAGTTAAACTTTCTCAGAAGCAACGAAAAATG
ATTGCATTGACTACCAAGGAAAACAATTCAGGAATGAATAGCATGGAAACAGTTTTATTC
ACTCCTTCAAAAGCCCCCAAACCAGTGAATGCATGGGCATCTTCTCTGCATTCAGTTTCA
TCCAAGTCATTCCGGGATTTCTTACTAGAAGAAAAAAAGTCTGTTACTAGCCATAGTTCA
GGCGATCATGTCAAAAAAGTTTCTTTTAAAGGAATTGAAAATTCTCAGGCACCAAAAATT
GTCAGATGCTCTACCCATGGTACCCCAGGACCAGAAGGCAACCATATTTCAGATTTACCA
CTTCTAGACAGTCCCAATCCCTGGCTATCTTCTTCAGTGACTGCTCCATCCATGGTAGCC
CCAGTCACTTTTGCATCTATTGTAGAAGAAGAACTACAACAAGAAGCAGCTCTTATTAGA
AGTCGAGAAAAACCGTTGGCTCTGATTCAGATTGAGGAGCATGCCATACAAGATTTATTG
GTTTTCTATGAGGCATTTGGCAACCCTGAAGAGTTTGTCATTGTTGAAAGGACACCGCAG
GGACCACTGGCAGTACCTATGTGGAATAAGCATGGATGCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 1353 |
| Molecular Weight
| 150526.6 |
| Theoretical pI
| 7.75 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Inhibitor of Bruton tyrosine kinase
MSSPMPDCTSKCRSLKHALDVLSVVTKGSENQIKAFLSSHCYNAATIKDVFGRNALHLVS
SCGKKGVLDWLIQKGVDLLVKDKESGWTALHRSIFYGHIDCVWSLLKHGVSLYIQDKEGL
SALDLVMKDRPTHVVFKNTDPTDVYTWGDNTNFTLGHGSQNSKHHPELVDLFSRSGIYIK
QVVLCKFHSVFLSQKGQVYTCGHGPGGRLGHGDEQTCLVPRLVEGLNGHNCSQVAAAKDH
TVVLTEDGCVYTFGLNIFHQLGIIPPPSSCNVPRQIQAKYLKGRTIIGVAAGRFHTVLWT
REAVYTMGLNGGQLGCLLDPNGEKCVTAPRQVSALHHKDIALSLVAASDGATVCVTTRGD
IYLLADYQCKKMASKQLNLKKVLVSGGHMEYKVDPEHLKENGGQKICILAMDGAGRVFCW
RSVNSSLKQCRWAYPRQVFISDIALNRNEILFVTQDGEGFRGRWFEEKRKSSEKKEILSN
LHNSSSDVSYVSDINSVYERIRLEKLTFAHRAVSVSTDPSGCNFAILQSDPKTSLYEIPA
VSSSSFFEEFGKLLREADEMDSIHDVTFQVGNRLFPAHKYILAVHSDFFQKLFLSDGNTS
EFTDIYQKDEDSAGCHLFVVEKVHPDMFEYLLQFIYTDTCDFLTHGFKPRIHLNKNPEEY
QGTLNSHLNKVNFHEDDNQKSAFEVYKSNQAQTVSERQKSKPKSCKKGKNIREDDPVRML
QTVAKKFDFSNLSSRLDGVRFENEKINVIAKNTGNKLKLSQKKCSFLCDVTMKSVDGKEF
PCHKCVLCARLEYFHSMLSSSWIEASSCAALEMPIHSDILKVILDYLYTDEAVVIKESQN
VDFICSVLVVADQLLITRLKEICEVALTEKLTLKNAAMLLEFAAMYSAKQLKLSCLQFIG
LNMAALLEARSLDVLSDGVLKDLSEFYRKMIPAMDRRVITPYQDGPDISYLEVEDGDIFL
KEEINMEQNHSETMFKKAKTKAKKKPRKRSDSSGGYNLSDIIQSPSSTGLLKSGKTNSVE
SLPELLTSDSEGSYAGVGSPRDLQSPDFTTGFHSDKIEAKVKPYVNGTSPVYSREDLKPW
EKSPILKISAPQPIPSNRIDTTSSASWVAGSFSPVSPPVVDLRTIMEIEESRQKCGATPK
SHLGKTVSHGVKLSQKQRKMIALTTKENNSGMNSMETVLFTPSKAPKPVNAWASSLHSVS
SKSFRDFLLEEKKSVTSHSSGDHVKKVSFKGIENSQAPKIVRCSTHGTPGPEGNHISDLP
LLDSPNPWLSSSVTAPSMVAPVTFASIVEEELQQEAALIRSREKPLALIQIEEHAIQDLL
VFYEAFGNPEEFVIVERTPQGPLAVPMWNKHGC
|
| External Links |
|---|
| GenBank ID Protein
| 57863304 |
| UniProtKB/Swiss-Prot ID
| Q9P2D0 |
| UniProtKB/Swiss-Prot Entry Name
| IBTK_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_015525.2 |
| GeneCard ID
| IBTK |
| GenAtlas ID
| IBTK |
| HGNC ID
| HGNC:17853 |
| References |
|---|
| General References
| Not Available |