| Identification |
|---|
| HMDB Protein ID
| CDBP02947 |
| Secondary Accession Numbers
| Not Available |
| Name
| Homer protein homolog 1 |
| Description
| Not Available |
| Synonyms
|
- Homer-1
|
| Gene Name
| HOMER1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Cell cycle control, cell division, chromosome partitioning |
| Specific Function
| Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoform 1 regulates the trafficking and surface expression of GRM5. Isoform 3 acts as a natural dominant negative, in dynamic competition with constitutively expressed isoform 1 to regulate synaptic metabotropic glutamate function. Isoform 3, may be involved in the structural changes that occur at synapses during long-lasting neuronal plasticity and development |
| GO Classification
|
Not Available
|
| Cellular Location
|
- Cytoplasm
- Cell junction
- Cell junction
- synapse
- synapse
- postsynaptic cell membrane
- postsynaptic density
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:5 |
| Locus
| 5q14.2 |
| SNPs
| HOMER1 |
| Gene Sequence
|
>1065 bp
ATGGGGGAGCAGCCGATTTTCAGCACTCGAGCTCATGTCTTCCAAATTGACCCAAACACA
AAGAAGAACTGGGTACCCACCAGCAAGCATGCAGTTACTGTGTCTTATTTCTATGACAGC
ACAAGAAATGTGTATAGGATAATCAGTTTAGATGGCTCAAAGGCAATAATAAATAGTACC
ATCACCCCAAACATGACATTTACTAAAACATCTCAGAAGTTTGGCCAGTGGGCTGATAGC
CGGGCAAACACCGTTTATGGATTGGGATTCTCCTCTGAGCATCATCTTTCGAAATTTGCA
GAAAAGTTTCAGGAATTTAAAGAAGCTGCTCGACTAGCAAAGGAAAAATCACAAGAGAAG
ATGGAACTTACCAGTACACCTTCACAGGAATCCGCAGGCGGGGATCTTCAGTCTCCTTTA
ACACCGGAAAGTATCAACGGGACAGATGATGAAAGAACACCTGATGTGACACAGAACTCA
GAGCCAAGGGCTGAACCAACTCAGAATGCATTGCCATTTTCACATAGTTCAGCAATCAGC
AAACATTGGGAGGCTGAACTGGCTACCCTCAAAGGAAATAATGCCAAACTCACTGCAGCC
CTGCTGGAGTCCACTGCCAATGTGAAACAATGGAAACAGCAACTTGCTGCCTATCAAGAG
GAAGCAGAACGTCTGCACAAGCGGGTGACTGAACTTGAATGTGTTAGTAGCCAAGCAAAT
GCAGTACATACTCATAAGACAGAATTAAATCAGACAATACAAGAACTGGAAGAGACACTG
AAACTGAAGGAAGAGGAAATAGAAAGGTTAAAACAAGAAATTGATAATGCCAGAGAACTA
CAAGAACAGAGGGATTCTTTGACTCAGAAACTACAGGAAGTAGAAATTCGGAACAAAGAC
CTGGAGGGACAACTGTCTGACTTAGAGCAACGTCTGGAGAAAAGTCAGAATGAACAAGAA
GCTTTTCGCAATAACCTGAAGACACTCTTAGAAATTCTGGATGGAAAGATATTTGAACTA
ACAGAATTACGAGATAACTTGGCCAAGCTACTAGAATGCAGCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 354 |
| Molecular Weight
| 40276.5 |
| Theoretical pI
| 5.14 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Homer protein homolog 1
MGEQPIFSTRAHVFQIDPNTKKNWVPTSKHAVTVSYFYDSTRNVYRIISLDGSKAIINST
ITPNMTFTKTSQKFGQWADSRANTVYGLGFSSEHHLSKFAEKFQEFKEAARLAKEKSQEK
MELTSTPSQESAGGDLQSPLTPESINGTDDERTPDVTQNSEPRAEPTQNALPFSHSSAIS
KHWEAELATLKGNNAKLTAALLESTANVKQWKQQLAAYQEEAERLHKRVTELECVSSQAN
AVHTHKTELNQTIQELEETLKLKEEEIERLKQEIDNARELQEQRDSLTQKLQEVEIRNKD
LEGQLSDLEQRLEKSQNEQEAFRNNLKTLLEILDGKIFELTELRDNLAKLLECS
|
| External Links |
|---|
| GenBank ID Protein
| 3834615 |
| UniProtKB/Swiss-Prot ID
| Q86YM7 |
| UniProtKB/Swiss-Prot Entry Name
| HOME1_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| AF093262 |
| GeneCard ID
| HOMER1 |
| GenAtlas ID
| HOMER1 |
| HGNC ID
| HGNC:17512 |
| References |
|---|
| General References
| Not Available |