| Identification |
|---|
| HMDB Protein ID
| CDBP02942 |
| Secondary Accession Numbers
| Not Available |
| Name
| Histone H2A type 1-B/E |
| Description
| Not Available |
| Synonyms
|
- Histone H2A.2
- Histone H2A/a
- Histone H2A/m
|
| Gene Name
| HIST1H2AB |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in DNA binding |
| Specific Function
| Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling |
| GO Classification
|
| Component |
| membrane-bounded organelle |
| intracellular membrane-bounded organelle |
| nucleus |
| nucleosome |
| protein-dna complex |
| macromolecular complex |
| organelle |
| Function |
| binding |
| nucleic acid binding |
| dna binding |
| Process |
| cellular process |
| cellular component organization at cellular level |
| organelle organization |
| chromosome organization |
| chromatin organization |
| nucleosome assembly |
| nucleosome organization |
|
| Cellular Location
|
- Nucleus
- Chromosome
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:6 |
| Locus
| 6p21.3 |
| SNPs
| HIST1H2AB |
| Gene Sequence
|
>393 bp
ATGTCTGGACGTGGAAAGCAAGGCGGCAAAGCTCGGGCAAAAGCTAAAACGCGTTCTTCC
AGGGCCGGTCTTCAGTTTCCAGTTGGCCGTGTGCACCGCCTCCTCCGCAAAGGCAACTAC
TCCGAACGAGTCGGGGCCGGCGCTCCAGTGTACCTGGCAGCGGTGCTGGAATATCTGACG
GCCGAGATCTTAGAGCTAGCTGGCAACGCGGCTCGCGACAATAAGAAGACCCGCATCATC
CCGCGCCACCTGCAGCTAGCCATCCGCAACGACGAGGAGCTAAATAAGCTTCTAGGTCGC
GTGACCATCGCGCAGGGCGGTGTCCTGCCCAACATCCAGGCCGTATTGCTGCCTAAGAAG
ACGGAGAGCCACCATAAGGCCAAGGGCAAGTGA
|
| Protein Properties |
|---|
| Number of Residues
| 130 |
| Molecular Weight
| 14135.4 |
| Theoretical pI
| 11.66 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Histone H2A type 1-B/E
MSGRGKQGGKARAKAKTRSSRAGLQFPVGRVHRLLRKGNYSERVGAGAPVYLAAVLEYLT
AEILELAGNAARDNKKTRIIPRHLQLAIRNDEELNKLLGRVTIAQGGVLPNIQAVLLPKK
TESHHKAKGK
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P04908 |
| UniProtKB/Swiss-Prot Entry Name
| H2A1B_HUMAN |
| PDB IDs
|
|
| GenBank Gene ID
| BC093836 |
| GeneCard ID
| HIST1H2AB |
| GenAtlas ID
| HIST1H2AB |
| HGNC ID
| HGNC:4734 |
| References |
|---|
| General References
| Not Available |