Showing Protein G-protein coupled receptor 6 (CDBP02931)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP02931
Secondary Accession Numbers Not Available
Name G-protein coupled receptor 6
Description Not Available
Synonyms
  1. Sphingosine 1-phosphate receptor GPR6
Gene Name GPR6
Protein Type Receptor
Biological Properties
General Function Involved in G-protein coupled receptor protein signaling pathway
Specific Function Orphan receptor with constitutive G(s) signaling activity that activate cyclic AMP. Promotes neurite outgrowth and blocks myelin inhibition in neurons
GO Classification
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
receptor activity
transmembrane receptor activity
molecular transducer activity
signal transducer activity
g-protein coupled receptor activity
Process
cell surface receptor linked signaling pathway
g-protein coupled receptor protein signaling pathway
signaling
signaling pathway
Cellular Location
  1. Cell membrane
  2. Multi-pass membrane protein (Probable)
Pathways
Gene Properties
Chromosome Location Chromosome:6
Locus 6q21
SNPs GPR6
Gene Sequence 
>1089 bp
ATGAACGCGAGCGCCGCCTCGCTCAACGACTCCCAGGTGGTGGTAGTGGCGGCCGAAGGA
GCGGCGGCGGCGGCCACAGCAGCAGGGGGGCCGGACACGGGCGAATGGGGACCCCCTGCT
GCGGCGGCTCTAGGAGCCGGCGGCGGAGCTAATGGGTCTCTGGAGCTGTCCTCGCAGCTG
TCGGCTGGGCCACCGGGACTCCTGCTGCCAGCGGTGAATCCGTGGGACGTGCTCCTGTGC
GTGTCGGGGACAGTGATCGCTGGAGAAAACGCGCTGGTGGTGGCGCTCATCGCGTCCACT
CCGGCGCTGCGCACGCCCATGTTCGTGCTGGTAGGCAGCCTGGCCACCGCTGACCTGTTG
GCGGGCTGTGGCCTCATCTTGCACTTTGTGTTCCAGTACTTGGTGCCCTCGGAGACTGTG
AGTCTGCTCACGGTGGGCTTCCTCGTGGCCTCCTTCGCCGCCTCTGTCAGCAGCCTGCTG
GCCATTACGGTGGACCGCTACCTGTCCCTGTATAACGCGCTCACCTATTACTCGCGCCGG
ACCCTGTTGGGCGTGCACCTCCTGCTTGCCGCCACTTGGACCGTGTCCCTAGGCCTGGGG
CTGCTGCCCGTGCTGGGCTGGAACTGCCTGGCAGAGCGCGCCGCCTGCAGCGTGGTGCGC
CCGCTGGCGCGCAGCCACGTGGCTCTGCTCTCCGCCGCCTTCTTCATGGTCTTCGGCATC
ATGCTGCACCTGTACGTGCGCATCTGCCAGGTGGTCTGGCGCCACGCGCACCAGATCGCG
CTGCAGCAGCACTGCCTGGCGCCACCCCATCTCGCTGCCACCAGAAAGGGTGTGGGTACA
CTGGCTGTGGTGCTGGGCACTTTCGGCGCCAGCTGGCTGCCCTTCGCCATCTATTGCGTG
GTGGGCAGCCATGAGGACCCGGCGGTCTACACTTACGCCACCCTGCTGCCCGCCACCTAC
AACTCCATGATCAATCCCATCATCTATGCCTTCCGCAACCAGGAGATCCAGCGCGCCCTG
TGGCTCCTGCTCTGTGGCTGTTTCCAGTCCAAAGTGCCCTTTCGTTCCAGGTCTCCCAGC
GAGGTCTGA
Protein Properties
Number of Residues 362
Molecular Weight 37880.8
Theoretical pI 7.74
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["75-94", "107-130", "143-164", "186-205", "231-249", "278-304", "310-331"]
Protein Sequence 
>G-protein coupled receptor 6
MNASAASLNDSQVVVVAAEGAAAAATAAGGPDTGEWGPPAAAALGAGGGANGSLELSSQL
SAGPPGLLLPAVNPWDVLLCVSGTVIAGENALVVALIASTPALRTPMFVLVGSLATADLL
AGCGLILHFVFQYLVPSETVSLLTVGFLVASFAASVSSLLAITVDRYLSLYNALTYYSRR
TLLGVHLLLAATWTVSLGLGLLPVLGWNCLAERAACSVVRPLARSHVALLSAAFFMVFGI
MLHLYVRICQVVWRHAHQIALQQHCLAPPHLAATRKGVGTLAVVLGTFGASWLPFAIYCV
VGSHEDPAVYTYATLLPATYNSMINPIIYAFRNQEIQRALWLLLCGCFQSKVPFRSRSPS
EV
GenBank ID Protein 55960729
UniProtKB/Swiss-Prot ID P46095
UniProtKB/Swiss-Prot Entry Name GPR6_HUMAN
PDB IDs Not Available
GenBank Gene ID AL591076
GeneCard ID GPR6
GenAtlas ID GPR6
HGNC ID HGNC:4515
References
General References Not Available