| Identification |
|---|
| HMDB Protein ID
| CDBP02908 |
| Secondary Accession Numbers
| Not Available |
| Name
| FRAS1-related extracellular matrix protein 3 |
| Description
| Not Available |
| Synonyms
|
Not Available
|
| Gene Name
| FREM3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in cell communication |
| Specific Function
| Extracellular matrix protein which may play a role in cell adhesion |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Process |
| cellular process |
| cell communication |
|
| Cellular Location
|
- Secreted
- extracellular space
- extracellular matrix
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:4 |
| Locus
| 4q31.21 |
| SNPs
| FREM3 |
| Gene Sequence
|
>6420 bp
ATGGCGGGGGCTTCTCGGCACCCGACTGGGACGCCCCGGCAGCTCCTTGTGGCGCTCGCC
TGCCTGCTCTTGAGTCGCCCCGCGCTGCAGGGACGGGCATCCTCACTTGGGACCGAGCCC
GACCCGGCGCTTTACCTGCCCGCCCGGGGTGCGCTTGACGGCACTCGCCCCGACGGCCCC
AGCGTGCTGATTGCCAACCCTGGACTCCGGGTGCCCCTGGGTCGTTCCCTTTGGCTCGAC
CCGCTCCGGGATCTGGTGATTGGAGTGCAGCCGGGGGACCGGTGCGAAGTCACGGTACTG
GACGCCCTGCCGCGGCTCAAGGGCGCGCTCTCCCCGCGCCGCTTCCCCTGCACCTTCGGG
CCCCGCCAAGTCCAGTACACTCACTTCGGCTCCCACAGCCCCGGACGCGCCCGGGTGCTG
CTGCAGCTGCGCTACGACGCCCCGACTCACACTCTGGTGCTGCCCTTCACGCTGGCGGTG
GACTTGGTCTTCTCCCAGCTGGAGCTGGTGACGCGTAACAGGCCTTTGGTAGTGGAGAAG
CTGCGAAGCTGGAGCCGCGCCATAGACAGGAGAGTGCTGGACTTCGCCTCCCTGAAGTCT
GGAGCCACGGCCACCCGCAGGTGCCGGCTTACCCCACTTCCTCACGAGGACGGCCCCCTG
CCCAAGTACGGGCGCTTGGTGGACGCGGTGGGGGCCCCTCTCCCCAGGGGCAAGGGCGTA
GACTGTGAGGCTTTCCTCCGTGCTGGGGTGCGCTATCAGCACACAGCCACCTCCTCGCCC
AACCGTGACTACGTGCCCATGATGGTGGAGCTGCTGGGGCCTGAGGGCCAAGACGCTGGG
TCCGCGGGTGTGCTGGTCCGCGAGCACTTCCAGCTGCTCGTGAGGATCCGCGGCGGAGCC
GAGAACACACCGCCCAGGCCCAGCTTCATGGCCACGATGATGATGGAGGTGGATCCACTG
GTGCTGACAGCCCTGACGCCTGACGCACTGGCCGCGGAGGACGTCGAGTCAGACCCTGGT
GACCTGGTGTTCAACATTCTGAACGCCCCCACTCACCCACCAGGGCACCCGGGGCAACAG
GGCTACGTGGTCAGCACCGACGACCCTCTAGGGCTTCCAGTCTCCTTCTTCACCCAGCAG
GAGCTGAGGGAGCTGAAGATTGCCTATCAGCCCCCTGCAGAGAACTCCCATGGGGAGCGC
CTCTTTCAGCTGGAGCTGGAGGTGGTGGACGGAGACGGCGCCGCCTCAGACCCCTTTGCC
TTCATGGTGACAGTGAAATCCATGAATACTCTGGTCCCAGTGGCTAGCCATAACAGGGGA
CTTGTGCTTTTTGAAGGTCAGTCAAGGCCCTTGTCCAGCACCCACAGCATTCCTATCAGT
GATAAAGATAACCTGGAAGAGGTGAAAATGGCTGCAGTCAGGGGCTTGAGACATGGGCAG
CTGGTGGTGTTTGGGGCACCTGCTGGGTGCAAGTATTTCACACCAGCGGACCTGGCAGCA
GGGCGAGTGGTGTATCAGCATGATGGCAGCAACACCTACAGTGACAATATCATCTTCCGG
ATGGAGGACGGGCACCACCAAGTGGACTTCCTCTTTCCCCTCACCATCCTACCTGTGGAT
GATGAACCACCAATGGTCAATACTAACACAGGACTCTCACTCACTGAAGGGCAGGTGGTC
CAGATCTCTCCCTTTGTACTGAGTGCTACTGATATTGACTCTGAGGACTCAACCATCCAC
TTTGTGCTGGAGAACCAGCCCCTAAAAGGAAATGAGGAAGAGCCTCAGTGGGAGTTGGCC
CCTGGTTCCTCCCACTCAGGCCACTACCTGGGGGACCTGTTGCTGCAGCAGGCTGAACTA
CCTCTCTCAACTGAAGATGAAGACTGGCACTACATGGAAAAGGAAGGGCTTTATGAGAAA
GTGGTGACTGAGTGGCTACAGAGAGACATAATGGAAGGGAGACTCTTCTACCGCCATCTT
GGACCACACAGCCCTCAATCTGTAATGGTCCAGCTGGCTTTCCATGTGCAGGATGACCAT
GACCCACCCAATCTCTCCAAACAGCACATTTTCACCATCAAGGTCCAACCAGTGGATATA
CTGAGTCCACAGCTGTATCCAGGAACTACACTAGAAATGACTGTACAAGAATACCAACTC
ACTCACTTCCAGAAGAATTTCCTCCGATACATTGACCAGGACTCTGATGACCAGAACCTA
TGGTACACCCTACTGACACTCCCGACTGACACAGATGGCAACCACCAAGTCCGGGCTGGA
GAAATTGTGCTCACTGATTCACCAGACACACTCATCATGCACTTTACCCAAGCCCAGGTA
AATCAGCATAAAGTTGCCTACCAGCCTCCACAGAAATTGGGTATTGCACCACGGGTTGTG
CAGTTTACTTACCAGGTGGAAGATGCTGCAGGCAATAGCGTGCCAGGCACATTCACATTA
TTCCTGCAACCTGTGGACAACCAGCCCCCAGAAGTCACCAACAGAGGCTTTGCTATCTTA
GAGGGAGGCAGCTTTAACCTCAGCAGTAATGAGCTGCATGTTACAGACCCAGACACAGAC
ATTGACCAAATTGTCTTCATATTAGTCCGGGGTCCCCAACATGGACACTTGCAGTACTTT
AAAAGATGTATGGTCCCAGGGGAATCTTTCATGCAAGCTGATGTTATTAACGGGAGTGTC
TCTTACCAGCATGGCAGAGACCAGACGACTACCAGTGACACTTTCCATCTGGAAGTAAGT
GATGGGGTGCACCATATACCCATCACCATCCCAATTTCTGTGCATCCCAATGTGGCTAAC
AGAAGTCCTAGGATCTCTCTCAGAAGTAGTTCATTATTGGATGTTTCTATAGACGTACTA
GAGAATAAAGCCACTGAAATTACCATGGGTGTCATCCATGGCAAAAGGAAGGATGTAGGT
GACTTGATGCTGTCTTTCATTGTAAAGGACAGCCCCAAACTGGGCACTATTCTGGTAAAT
GGTTTGCCCACAGAACGATTCACCCAAGAGGATCTCATCAATGGGAGAGTAGCCTATGCC
CACACTGCAGGTGAAGTTGGTTTTCAAAAGCAGCACGATGCCTTCAGCCTCATCCTCTCC
AAAGATTCTTACCAATGGGTAGTGGGGAATAGCATAATAGAGAAAGTACAGGTACAAGTA
ACTGTGCTGCCTGTGGACAATGTGGGACCCAAGGTCTTCGTCGGGGAGTCCTTCATTGTC
TATGAAGGTGAGAAGAACTCCTTGACCTTACAACATCTCCATGTTGAAGATGTGGACACT
CATCAAGATGAACTCCTCTGCACAGTGACTAGTCAGCCAGCCTCTGGCTACCTGGAAAAG
ATTGCATCAGCTCCTGGTTCAAAAATGTCCCAGTCTGGTAGCCCTATCAGTGCTTTCTCC
CTCAGAGATATCCAAGTGAGGCATATCAATTATGTACAGAGTATTCACAAGGGAGTAGAG
CCACAAGAGGACCAATTCACCTTTTATTGCTCTGATGGCATCAACTTCTCCCCAAATGTC
TTCTTCCCTATAATCATCCTACCCACCAATGATGAGCAGCCTAAACTTTTTGCCCATGAG
TTTAAGGTACTAGAGGGGATGAGCCTGGTCATAGACACCCAGCTGCTTAATGGAGCAGAT
GCTGACCTGCCACCAAATGAGCTCCACTTTCAACTCACAGCCCTCCCTCGGCATGGACGA
ATCATACAGCAGCTGGCTACAGGCAGCCAGCCCATCCACAGCTTCACCCTCAAGGAGATC
CAGGAGGCCTCCACCATTGTGTATGAGCATGATGACTCAGAGACAAAAGAGGACAGTTTT
GAGGTCTGGCTGAGTGACGGCAAGCACACAACCCACAGGAAGGTACCCATTGTAGTGACC
CTAGTGGATGATGAAACTCCTCACCTGACTGTCAACAATGGGCTGAAGGTAGAGAAAGGA
CACTCTGAGATCATCACAAATCGGATCCTCAAGGCCACAGATCTTGACTCAGATGATAAA
AGCCTCAGTTTTGTCCTCCATTCTGGGCCTCAACAAGGGCTTCTACAGAGGCTGAGAAAA
CCCAGAGGAGAAGTGAGGAACAATCTTACTCTGGGAATGAACTTTACCCAGGATGAGATT
AACAGAGGCCTCATCTGCTATATCCACACAGGCCAAGAAGGGATTGTTGACATTATCAAG
TTTGATGTTACTGATGGGGTTAACACTTTGACAGACCACTACTTCTATGTCACCATTGGC
AACTTAGACAGCGTCTTCCCTGAGGTAATCAGCAAAAGGATCACCTTGATAGAAGGTGCC
AGAGTGACCCTTACCAACAATCTGCTTACCAACAGTGACATCAACAGCTCTGATGAACAT
CACTTTAGCATTACACGGGCTCCAAGCCTGGGTCACTTAGAAAGTTCTGACTATGCTGGG
GAACCCATTGCCTCTTTCACTCAACTTCAATTGGCTAGCAACAAAATATCCTATGTCCAT
ACTTCAAATGATGAGAAAAAGATGGACAGCTTCGAATTTCAAGTGATCGGCGAACTCTAC
CCTGTGTTCAGAACCTTCAGGATCTTCATCACTGATGTGGATAATAAGAAACCTATCTTG
ACCATCCATAGACTAACACTACAGAAAGAGGATAGCCAACTGATCACTCTCCTTGAGTTG
ACAGTGGAAGACAGTGATACCCCAGATGACCTTATTCTCTTTACCATCACCCAGGTCCCC
ATGCATGGCAAGATTTTGTACAATGGTAGCCGTCCCGTGACCACTTTCACCAAGCAAGAC
CTGAACAAGAACCTGATTAGCTACAAGCATGACGGCAGTGAGACCACTGAAGATAGTTTC
TCCTTGACTGTGACAGACGGCACTCACACTGATTTCTATGTCCTACCAGACACTGCCCTG
GCGACACACAAACCTCAAGTAATGAGGGTCCAGATAAGATCATTAGACAATAGGCTTCCC
CAGATTACTACCAACAGGGGTGCCCCAGCCTTGAAGCGCCTTCACACTGGACACATGGGC
TTCCTGATTACCAGCAAGTCTCTGAAGGCAGAAGATCAGGACAGTCCCCACAGGCTTCTG
AAGTATAAAGTGACCAGAGGACCAGAGCATGGCTTCATTATCAAAACTGGCCTTGGAAAC
CAGAGCACTCGAGTGTTTACACAAGCTGACATTGATGAGATGAAGATATCCTATGTCTTG
AATGAGGGCAGCAACGCATCAAAGGACATCTTCTATTTCTCTGTTGAAGACAATGGAGGA
AATAAACTAACAAATCAGCCTTTCCATCTAAACTGGGCTTGGATTTGTTTGGAGAAAGAG
TACTACATTGTGGATGAAGATTCCACATTCTTAGAAGTGACCCTTACACGCAGAGGATAC
CTTGGAGAAACATCATTTATCAGCATTGGTACCAAAGATGAAACTGCAAAAAAAGACAAA
GATTTCAAATGGAAGACCAATAAACAGATCCAGTTCAATCCTGGACAGACTACAGCCACA
TGGAGGGTGAGAATTATACCTGACAATGAATATGAGACTTCAGAGACCTTCCAGATCATT
CTGTCTGAACCTCTCATGGCTGTACTGGAGTTTCCAGAAATGGCAACGGTTGAAATTGTA
GACCCTGGAGATGAATCAACAGTTTATATTCCAGAGGCGGAATACAAAATAGAAGAGGAC
ATTGGGGAACTTTTGATTCCAGTAAGACGATCTGGAGATGCAAGCCAGGAACTAATCGTC
ATTTGCTCCACACGTCAAGGTTCTGCCACAGGCACGATTTCTTCCACAGTGTTATTCTCT
GATTACATCTCACGTCCAGAAGACCACACCAGCATCCTCCACTTTGACAAGAATGAGACA
CAGAAGACCTGCCAGGTCCTGATCATTGATGACTCCCTTTATGAAGAGGAGGAATCCTTC
AGCGTTTCACTTAGGCTGCCAGTGGGAGGACAGCTGGGAGCCAGATTCCCCACCACTAAG
GTGACTATTCTGGCTGATCGTTATGATGAACCTGTCCTGCACTTTGGGGATGCTGAATAT
CACGTCAATGAAAGTGCTCGCTACGTGGAGGTTTGTGTTTGGAGAAGAGGCACTGATCTT
TCCCAACCATCATCCATCGCCGTGCGCTCCAGAAAGTCAGAGCAGGAGTCAGCAGAAGCT
GGAACAGATTATGTTGGTATCAGCCGAAACCTGGACTTTGCTCCAGGCGTGCGCATGCAG
ACATTCCAAGTGACCATCCTTGATGACCTGGGACAGCCTACCTTGGAAGGCCCAGAGAAG
TTTGAATTACTTCTTCAGATGCCTATGGGTGCAGTGCTTGGAGAACCAAATAAAACTACC
ATTTTCATCGAGGACACCATCACGGACTGTAAGCAGAGTGCTTGTAGTTCCTTTGATTGA
|
| Protein Properties |
|---|
| Number of Residues
| 2135 |
| Molecular Weight
| 237762.4 |
| Theoretical pI
| 4.98 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>FRAS1-related extracellular matrix protein 3
MAGASRHPTGTPRQLLVALACLLLSRPALQGRASSLGTEPDPALYLPARGALDGTRPDGP
SVLIANPGLRVPLGRSLWLDPLRDLVIGVQPGDRCEVTVLDALPRLKGALSPRRFPCTFG
PRQVQYTHFGSHSPGRARVLLQLRYDAPTHTLVLPFTLAVDLVFSQLELVTRNRPLVVEK
LRSWSRAIDRRVLDFASLKSGATATRRCRLTPLPHEDGPLPKYGRLVDAVGAPLPRGKGV
DCEAFLRAGVRYQHTATSSPNRDYVPMMVELLGPEGQDAGSAGVLVREHFQLLVRIRGGA
ENTPPRPSFMATMMMEVDPLVLTALTPDALAAEDVESDPGDLVFNILNAPTHPPGHPGQQ
GYVVSTDDPLGLPVSFFTQQELRELKIAYQPPAENSHGERLFQLELEVVDGDGAASDPFA
FMVTVKSMNTLVPVASHNRGLVLFEGQSRPLSSTHSIPISDKDNLEEVKMAAVRGLRHGQ
LVVFGAPAGCKYFTPADLAAGRVVYQHDGSNTYSDNIIFRMEDGHHQVDFLFPLTILPVD
DEPPMVNTNTGLSLTEGQVVQISPFVLSATDIDSEDSTIHFVLENQPLKGNEEEPQWELA
PGSSHSGHYLGDLLLQQAELPLSTEDEDWHYMEKEGLYEKVVTEWLQRDIMEGRLFYRHL
GPHSPQSVMVQLAFHVQDDHDPPNLSKQHIFTIKVQPVDILSPQLYPGTTLEMTVQEYQL
THFQKNFLRYIDQDSDDQNLWYTLLTLPTDTDGNHQVRAGEIVLTDSPDTLIMHFTQAQV
NQHKVAYQPPQKLGIAPRVVQFTYQVEDAAGNSVPGTFTLFLQPVDNQPPEVTNRGFAIL
EGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQHGHLQYFKRCMVPGESFMQADVINGSV
SYQHGRDQTTTSDTFHLEVSDGVHHIPITIPISVHPNVANRSPRISLRSSSLLDVSIDVL
ENKATEITMGVIHGKRKDVGDLMLSFIVKDSPKLGTILVNGLPTERFTQEDLINGRVAYA
HTAGEVGFQKQHDAFSLLSKDSYQWVVGNSIIEKVQVQVTVLPVDNVGPKVFVGESFIVY
EGEKNSLTLQHLHVEDVDTHQDELLCTVTSQPASGYLEKIASAPGSKMSQSGSPISAFSL
RDIQVRHINYVQSIHKGVEPQEDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAHEF
KVLEGMSLVIDTQLLNGADADLPPNEHFQLTALPRHGRIIQQLATGSQPIHSFTLKEIQE
ASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPHLTVNNGLKVEKGHS
EIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNLTLGMNFTQDEINR
GLICYIHTGQEGIVDIIKFDVTDGVNTLTDHYFYVIGNLDSVFPEVISKRITLIEGARVT
LTNNLLTNSDINSSDEHHFSITRAPSLGHLESSDYAGEPIASFTQLQLASNKISYVHTSN
DEKKMDSFEFQVIGELYPVFRTFRIFITDVDNKKPILTIHRLTLQKEDSQLITLLELTVE
DSDTPDDLILFTITQVPMHGKILYNGSRPVTTFTKQDLNKNLIYKHDGSETTEDSFSLTV
TDGTHTDFYVLPDTALATHKPQVMRVQIRSLDNRLPQITTNRGAPALKRLHTGHMGFLIT
SKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGLGNQSTRVFTQADIDEMKISYVLNEGS
NASKDIFYFSVEDNGGNKLTNQPFHLNWAWICLEKEYYIVDEDSTFLEVTLTRRGYLGET
SFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTATWRVRIIPDNEYETSETFQIILSEP
LMAVLEFPEMATVEIVDPGDESTVYIPEAEYKIEEDIGELLIPVRRSGDASQELIVICST
RQGSATGTISSTVLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSL
RLPVGGQLGARFPTTKVTILADRYDEPVLHFGDAEYHVNESARYVEVCVWRRGTDLSQPS
SIAVRSRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDDLGQPTLEGPEKFELL
LQMPMGAVLGEPNKTTIFIEDTITDCKQSACSSFD
|
| External Links |
|---|
| GenBank ID Protein
| 270265871 |
| UniProtKB/Swiss-Prot ID
| P0C091 |
| UniProtKB/Swiss-Prot Entry Name
| FREM3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001168235 |
| GeneCard ID
| FREM3 |
| GenAtlas ID
| FREM3 |
| HGNC ID
| HGNC:25172 |
| References |
|---|
| General References
| Not Available |