| Identification |
|---|
| HMDB Protein ID
| CDBP02906 |
| Secondary Accession Numbers
| Not Available |
| Name
| FRAS1-related extracellular matrix protein 1 |
| Description
| Not Available |
| Synonyms
|
- Protein QBRICK
|
| Gene Name
| FREM1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in binding |
| Specific Function
| Extracellular matrix protein that plays a role in epidermal differentiation and is required for epidermal adhesion during embryonic development |
| GO Classification
|
| Component |
| cell part |
| membrane part |
| intrinsic to membrane |
| integral to membrane |
| Function |
| binding |
| Process |
| cellular process |
| cell communication |
|
| Cellular Location
|
- Secreted
- extracellular space
- extracellular matrix
- basement membrane
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:9 |
| Locus
| 9p22.3 |
| SNPs
| FREM1 |
| Gene Sequence
|
>6540 bp
ATGAACTCTCTGAGTTGGGGGGCTGCGAATGCCGTGCTGCTGCTGCTCCTCCTGGCCTGG
GCCAGCCCCACCTTCATCAGCATCAACCGCGGGGTGAGGGTGATGAAGGGCCACTCTGCC
TTCCTGTCAGGAGATGACCTGAAGTTTGCCATCCCTAAAGAGAAAGATGCCTGCAAAGTG
GAAGTTGTGATGAATGAGCCAATAACCCAGAGGGTTGGGAAACTCACTCCACAGGTCTTT
GACTGCCATTTCCTTCCCAACGAAGTCAAGTATGTTCACAATGGTTGTCCAATTCTTGAT
GAAGACACAGTGAAGCTCAGACTTTACAGATTTACTGAAAGAGATACCTTCATAGAAACT
TTTATCCTGTGGGTCTATCTCCTGGAACCAGACTGTAACATCATCCATATGAGTAACAAT
GTGCTGGAGGTGCCTGAATTCAATGGCTTGTCCCAAGCGATTGATAAAAATCTGCTCAGA
TTCGATTATGATAGGATGGCTAGCCTGGAATGTACCGTCAGCCTGGACACTGCGAGAACT
CGGCTGCCAGCCCATGGCCAGATGGTTCTCGGGGAGCCTCGACCAGAAGAACCTCGTGGA
GATCAGCCACACAGTTTTTTCCCAGAGTCCCAACTGAGAGCAAAACTGAAGTGTCCAGGT
GGGAGCTGTACCCCAGGATTAAAGAAAATAGGAAGCCTCAAAGTGAGCTGTGAGGAGTTC
CTGCTGATGGGCCTTCGTTATCAGCATCTGGATCCCCCTTCACCCAACATTGATTATATC
TCCATCCAACTGGACCTCACAGATACCAGGAGCAAAATTGTGTACAAGTCAGAGAGTGCG
TGGCTGCCTGTCTATATCAGAGCTGGAATTCCGAATCAGATTCCAAAGGCTGCATTCATG
GCCGTGTTTATTCTGGAAGTGGATCAGTTCATCCTGACCTCCTTGACTACATCAGTTCTG
GACTGTGAAGAAGATGAGACCCCTAAACCCTTGCTGGTGTTCAACATTACTAAAGCCCCG
CTCCAGGGCTATGTGACTCACCTGTTGGATCACACCAGACCAATCTCCTCATTCACCTGG
AAAGATCTCAGTGACATGCAGATCGCCTATCAGCCACCAAACAGCAGCCATTCTGAGAGG
AGACATGATGAGGTAGAATTGGAGGTATACGACTTCTTCTTTGAAAGGAGTGCACCTATG
ACAGTCCACATCTCCATCAGAACAGCAGATACAAATGCCCCCCGTGTATCCTGGAATACA
GGTCTGAGTCTCCTTGAGGGGCAGTCTCGAGCCATCACTTGGGAACAGTTTCAGCTTGTC
GACAATGACGACATTGGTGCTGTCCGGCTAGTCACCGTTGGTGGCCTGCAGCATGGATGG
CTGACTTTAAGAGGGGGGAAAGGGTTTCTCTTCACCGTGGCTGACCTCCAGGCTGGAGTT
GTTCGCTATCATCATGATGACAGCGACTCCACCAAAGACTTCGTGGTCTTCCGGATATTT
GATGGCCATCACAGCATCCGTCACAAATTCCCCATCAACGTCTTGCCCAAAGATGATAGT
CCCCCGTTCCTCATAACCAATGTTGTGATTGAACTGGAGGAGGGGCAGACCATCCTGATC
CAGGGATCCATGCTGCGAGCTTCAGATGTGGACGCCAGTGATGACTACATCTTCTTCAAT
ATCACAAAGCCTCCACAGGCTGGGGAGATCATGAAGAAGCCAGGGCCAGGACTGATAGGC
TATCCTGTCCATGGCTTCCTTCAGAGGGATTTGTTTAATGGAATCATTTATTATCGTCAT
TTTGGTGGAGAAATCTTTGAAGATTCTTTTCAATTTGTCCTGTGGGACAGCCATGAACCT
CCAAATCTTTCAGTGCCACAGGTGGCAACAATCCATATAACTCCAGTGGATGACCAGCTT
CCAAAAGAGGCTCCTGGAGTTTCTCGGCATTTGGTTGTCAAGGAAACTGAGGTGGCCTAT
ATAACTAAGAAACAGCTACATTTTATAGATTCAGAATCATATGACAGGGAGCTGGTCTAC
ACAATAACTACTCCTCCATTTTTCTCCTTCAGTCACAGACACTTGGATGCTGGGAAATTA
TTTATGGTGGACAGCATACCAAAAGTAGTTAAGAATCCTACGGCCCTGGAGCTGAGGTCA
TTCACTCAGCATGCTGTGAACTATATGAAAGTGGCCTACATGCCCCCCATGCAAGACATT
GGTCCCCATTGCAGAGATGTCCAGTTCACATTTTCTGTCAGTAACCAACATGGCGGTACT
TTGCATGGGATCTGCTTTAACATTACAATCCTCCCAGTGGACAATCAAGTTCCTGAGGCG
TTCACCAACCCTCTGAAAGTGACTGAGGGAGGTCAAAGCATCATCAGCACAGAGCACATT
CTAATTTCTGATGCAGATACCAAGCTGGACAATATTGACCTCTCCCTGCGGGAATTGCCT
CTGCACGGAAGGGTGGAGCTGAATGGATTTCCTCTAAATTCAGGGGGCACATTTTCTTGG
GGCGATCTCCATACCTTAAAAGTTAGGTATCAACATGATGGAACTGAAGTTCTTCAGGAT
GACCTAGTCTTGGAGGTCACCGATGGCACAAATTCAGCAGAATTTGTACTACATGTTGAG
GTATTCCCTGTCAACGATGAGCCACCAGTCTTAAAGGCTGACCTCATGCCTGTCATGAAT
TGCTCAGAGGGAGGAGAGGTGGTCATCACCTCTGAATACATTTTTGCTACTGATGTGGAC
AGCGATAACTTGAAGTTGATGTTTGTGATTGCTCGCGAACCTCAGCATGGGGTGGTGAGG
AGAGCTGGAGTCACAGTGGATCAGTTCTCTCAGAGAGATGTTATCTCAGAGGCCGTGACA
TACAAACACACAGGTGGCGAGATTGGCCTGATGCCTTGTTTTGACACCATTACATTGGTG
GTTTCGGATGGAGAGGCTGGCCCTTTTGTGAATGGCTGTTGCTACAATGGACCCAATCCA
TCTGTTCCACTTCATGCGTCCTTTCCAGTGTATGATCTCAACATCACGGTATACCCAGTA
GACAACCAGCCACCTTCCATTGCAATAGGTCCCGTGTTTGTTGTAGATGAGGGCTGCTCA
ACAGCCCTTACTGTTAACCATTTGTCCGCCACTGACCCTGACACTGCAGCAGATGACTTG
GAATTTGTTTTGGTTTCTCCTCCTCAGTTTGGCTACCTCGAAAATATACTCCCTTCTGTG
GGTTTTGAAAAAAGCAATATTGGCATAAGTATAGATTCATTTCAGTGGAAAGACATGAAC
GCTTTTCACATTAACTATGTGCAGTCCAGGCATCTGAGGATAGAACCAACTGCCGACCAG
TTCACGGTGTACGTCACAGATGGGAAGCATCACTCCTTGGAGATACCATTTTCTATTATA
ATCAACCCCACAAATGATGAAGCTCCTGACTTTGTAGTGCAGAATATTACTGTGTGTGAG
GGTCAGATGAAAGAGCTGGACTCTTCCATCATCAGCGCTGTGGACCTGGACATTCCCCAG
GATGCCCTGCTGTTCAGCATCACTCAAAAGCCACGCCATGGCCTCCTCATCGATAGGGGG
TTTAGCAAAGACTTCTCTGAGAATAAGCAGCCAGCCAACCCTCACCAGAAACATGCACCT
GTTCACAGCTTTTCCATGGAACTCCTCAAGACTGGAATGAGGTTGACGTACATGCATGAT
GACTCAGAGAGCCTTGCTGATGATTTTACAATCCAATTGTCAGATGGGAAACATAAGATA
CTTAAAACCATTTCAGTAGAGGTCATCCCAGTTAATGATGAAAAACCAATGCTGAGCAAG
AAGGCTGAAATTGCAATGAATATGGGTGAAACTCGTATTATTTCCAGTGCTATTCTTTCA
GCCATAGATGAAGACTCACCCAGGGAGAAGATTTACTATGTATTTGAAAGGCTTCCCCAA
AATGGGCAACTTCAGCTTAAGATAGGGAGGGACTGGGTTCCTCTCTCCCCTGGCATGAAA
TGCACTCAGGAGGAAGTGGATCTGAACTTGCTGAGATACACACACACCGGGGCAATGGAT
TCCCAGAATCAAGATAGCTTCACCTTCTACCTTTGGGATGGCAACAACAGGTCCCCTGCT
CTTGACTGTCAAATCACCATCAAGGACATGGAAAAAGGTGATATTGTCATCCTTACAAAA
CCACTCGTGGTGTCTAAAGGTGATAGAGGTTTCTTAACAACCACCACGCTCCTGGCTGTG
GACGGAACAGACAAGCCTGAGGAACTGCTCTATGTCATCACCTCCCCTCCGCGATATGGC
CAGATCGAATATGTTCACTATCCTGGAGTTCCCATTACAAACTTCAGCCAAATGGATGTA
GTGGGGCAGACAGTTTGCTATGTACACAAGAGCAAGGTGACTGTCTCCAGTGACAGATTC
AGATTCATCATCAGCAATGGACTGCGGACCGAGCACGGGGTGTTTGAGATCACACTGGAG
ACTGTGGACAGAGCCCTGCCTGTGGTAACCAGGAACAAGGGGTTGAGACTGGCCCAAGGG
GCCGTGGGCCTGCTTTCCCCTGACCTCCTTCAGCTGACCGACCCTGATACACCTGCGGAG
AACCTCACCTTCCTCTTGGTTCAGCTCCCCCAGCATGGCCAGCTCTACCTGTGGGGGACA
GGGCTACTTCAACACAATTTCACCCAGCAGGATGTGGACAGCAAGAATGTGGCCTATCGG
CACTCAGGAGGGGACTCCCAGACTGACTGCTTTACTTTCATGGCCACAGACGGGACAAAC
CAAGGCTTTATTGTGAATGGGAGAGTGTGGGAAGAACCTGTTTTATTCACCATTCAGGTA
GACCAATTGGACAAAACAGCTCCTCGTATCACACTCTTGCATTCCCCTTCTCAAGTGGGG
CTCCTGAAAAATGGCTGCTACGGGATTTACATCACTTCCCGCGTGTTGAAGGCATCAGAC
CCTGACACTGAGGACGATCAGATCATCTTTAAAATTCTACAAGGCCCAAAACATGGACAT
CTGGAGAACACAACAACAGGTGAATTTATCCATGAGAAATTTAGCCAAAAGGACTTAAAC
AGTAAGACTATTCTTTACATCATAAACCCATCTTTGGAAGTAAATTCAGATACCGTGGAA
TTTCAAATCATGGACCCCACAGGGAACTCGGCCACTCCTCAAATTTTGGAACTGAAGTGG
TCTCATATTGAATGGTCACAGACCGAATATGAAGTCTGTGAGAATGTGGGTTTGTTGCCC
TTGGAAATTATCAGAAGGGGATATTCCATGGACTCGGCCTTTGTGGGTATAAAGGTCAAC
CAAGTGTCAGCTGCAGTTGGAAAAGATTTCACCGTGATTCCATCTAAACTGATTCAGTTT
GACCCAGGAATGTCAACTAAGATGTGGAATATAGCAATTACCTATGACGGATTAGAGGAA
GATGATGAGGTCTTTGAAGTAATTCTGAACTCCCCTGTGAATGCAGTTCTTGGCACAAAG
ACAAAAGCTGCAGTGAAAATTTTGGACTCAAAAGGAGGACAATGCCATCCTTCATATTCC
TCCAACCAAAGCAAGCACAGCACATGGGAGAAGGGCATTTGGCATCTGCTGCCCCCAGGG
TCTTCCTCATCCACCACTTCTGGTTCCTTTCATCTGGAAAGAAGACCTCTTCCATCTTCC
ATGCAGCTAGCAGTCATCAGGGGAGACACCCTGCGGGGCTTTGATTCTACAGATCTTTCT
CAAAGGAAGCTTAGGACCCGTGGGAATGGCAAAACAGTTCGTCCATCCTCTGTTTATAGA
AATGGAACAGACATCATCTATAATTATCATGGGATAGTTTCCTTGAAACTGGAGGATGAC
AGTTTCCCAACTCACAAAAGGAAGGCCAAAGTATCCATCATTAGTCAGCCACAAAAGACA
ATCAAAGTGGCAGAACTGCCTCAAGCAGATAAGGTGGAATCCACAACTGACTCACACTTC
CCCAGACAGGACCAGTTGCCCTCATTTCCAAAGAACTGCACTCTGGAATTAAAGGGACTC
TTCCATTTTGAAGAAGGCATCCAGAAGCTGTATCAGTGCAATGGGATCGCCTGGAAAGCC
TGGAGTCCCCAAACCAAGGATGTGGAAGACAAATCCTGTCCAGCCGGGTGGCACCAGCAC
TCAGGCTACTGTCACATCTTGATCACAGAGCAGAAAGGCACCTGGAATGCGGCTGCCCAA
GCTTGCAGGGAACAATACCTGGGCAACCTTGTAACTGTATTCTCCAGGCAGCACATGCGG
TGGCTCTGGGACATTGGTGGGAGAAAGTCCTTTTGGATAGGTTTGAACGACCAAGTGCAT
GCTGGCCACTGGGAGTGGATCGGTGGTGAACCTGTTGCCTTCACCAATGGGAGAAGAGGG
CCCTCTCCACGCTCCAAGCTTGGAAAGAGCTGTGTTTTGGTTCAAAGACAAGGGAAATGG
CAAACAAAAGACTGTAGGAGAGCCAAACCTCATAATTATGTGTGTTCCAGAAAACTCTAA
|
| Protein Properties |
|---|
| Number of Residues
| 2179 |
| Molecular Weight
| 244152.5 |
| Theoretical pI
| 5.75 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>FRAS1-related extracellular matrix protein 1
MNSLSWGAANAVLLLLLLAWASPTFISINRGVRVMKGHSAFLSGDDLKFAIPKEKDACKV
EVVMNEPITQRVGKLTPQVFDCHFLPNEVKYVHNGCPILDEDTVKLRLYRFTERDTFIET
FILWVYLLEPDCNIIHMSNNVLEVPEFNGLSQAIDKNLLRFDYDRMASLECTVSLDTART
RLPAHGQMVLGEPRPEEPRGDQPHSFFPESQLRAKLKCPGGSCTPGLKKIGSLKVSCEEF
LLMGLRYQHLDPPSPNIDYISIQLDLTDTRSKIVYKSESAWLPVYIRAGIPNQIPKAAFM
AVFILEVDQFILTSLTTSVLDCEEDETPKPLLVFNITKAPLQGYVTHLLDHTRPISSFTW
KDLSDMQIAYQPPNSSHSERRHDEVELEVYDFFFERSAPMTVHISIRTADTNAPRVSWNT
GLSLLEGQSRAITWEQFQVVDNDDIGAVRLVTVGGLQHGWLTLRGGKGFLFTVADLQAGV
VRYHHDDSDSTKDFVVFRIFDGHHSIRHKFPINVLPKDDSPPFLITNVVIELEEGQTILI
QGSMLRASDVDASDDYIFFNITKPPQAGEIMKKPGPGLIGYPVHGFLQRDLFNGIIYYRH
FGGEIFEDSFQFVLWDSHEPPNLSVPQVATIHITPVDDQLPKEAPGVSRHLVVKETEVAY
ITKKQLHFIDSESYDRELVYTITTPPFFSFSHRHLDAGKLFMVDSIPKVVKNPTALELRS
FTQHAVNYMKVAYMPPMQDIGPHCRDVQFTFSVSNQHGGTLHGICFNITILPVDNQVPEA
FTNPLKVTEGGQSIISTEHILISDADTKLDNIDLSLRELPLHGRVELNGFPLNSGGTFSW
GDLHTLKVRYQHDGTEVLQDDLLLEVTDGTNSAEFVLHVEVFPVNDEPPVLKADLMPVMN
CSEGGEVVITSEYIFATDVDSDNLKLMFVIAREPQHGVVRRAGVTVDQFSQRDVISEAVT
YKHTGGEIGLMPCFDTITLVVSDGEAGPFVNGCCYNGPNPSVPLHASFPVYDLNITVYPV
DNQPPSIAIGPVFVVDEGCSTALTVNHLSATDPDTAADDLEFVLVSPPQFGYLENILPSV
GFEKSNIGISIDSFQWKDMNAFHINYVQSRHLRIEPTADQFTVYVTDGKHHSLEIPFSII
INPTNDEAPDFVVQNITVCEGQMKELDSSIISAVDLDIPQDALLFSITQKPRHGLLIDRG
FSKDFSENKQPANPHQKHAPVHSFSMELLKTGMRLTYMHDDSESLADDFTIQLSDGKHKI
LKTISVEVIPVNDEKPMLSKKAEIAMNMGETRIISSAILSAIDEDSPREKIYYVFERLPQ
NGQLQLKIGRDWVPLSPGMKCTQEEVDLNLLRYTHTGAMDSQNQDSFTFYLWDGNNRSPA
LDCQITIKDMEKGDIVILTKPLVVSKGDRGFLTTTTLLAVDGTDKPEELLYVITSPPRYG
QIEYVHYPGVPITNFSQMDVVGQTVCYVHKSKVTVSSDRFRFIISNGLRTEHGVFEITLE
TVDRALPVVTRNKGLRLAQGAVGLLSPDLLQLTDPDTPAENLTFLLVQLPQHGQLYLWGT
GLLQHNFTQQDVDSKNVAYRHSGGDSQTDCFTFMATDGTNQGFIVNGRVWEEPVLFTIQV
DQLDKTAPRITLLHSPSQVGLLKNGCYGIYITSRVLKASDPDTEDDQIIFKILQGPKHGH
LENTTTGEFIHEKFSQKDLNSKTILYIINPSLEVNSDTVEFQIMDPTGNSATPQILELKW
SHIEWSQTEYEVCENVGLLPLEIIRRGYSMDSAFVGIKVNQVSAAVGKDFTVIPSKLIQF
DPGMSTKMWNIAITYDGLEEDDEVFEVILNSPVNAVLGTKTKAAVKILDSKGGQCHPSYS
SNQSKHSTWEKGIWHLLPPGSSSSTTSGSFHLERRPLPSSMQLAVIRGDTLRGFDSTDLS
QRKLRTRGNGKTVRPSSVYRNGTDIIYNYHGIVSLKLEDDSFPTHKRKAKVSIISQPQKT
IKVAELPQADKVESTTDSHFPRQDQLPSFPKNCTLELKGLFHFEEGIQKLYQCNGIAWKA
WSPQTKDVEDKSCPAGWHQHSGYCHILITEQKGTWNAAAQACREQYLGNLVTVFSRQHMR
WLWDIGGRKSFWIGLNDQVHAGHWEWIGGEPVAFTNGRRGPSQRSKLGKSCVLVQRQGKW
QTKDCRRAKPHNYVCSRKL
|
| External Links |
|---|
| GenBank ID Protein
| 58430435 |
| UniProtKB/Swiss-Prot ID
| Q5H8C1 |
| UniProtKB/Swiss-Prot Entry Name
| FREM1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AB160987 |
| GeneCard ID
| FREM1 |
| GenAtlas ID
| FREM1 |
| HGNC ID
| HGNC:23399 |
| References |
|---|
| General References
| Not Available |