| Identification |
|---|
| HMDB Protein ID
| CDBP02902 |
| Secondary Accession Numbers
| Not Available |
| Name
| Peptidyl-prolyl cis-trans isomerase FKBP8 |
| Description
| Not Available |
| Synonyms
|
- 38 kDa FK506-binding protein
- 38 kDa FKBP
- FK506-binding protein 8
- FKBP-38
- FKBP-8
- FKBPR38
- PPIase FKBP8
- Rotamase
- hFKBP38
|
| Gene Name
| FKBP8 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in protein folding |
| Specific Function
| Constitutively inactive PPiase, which becomes active when bound to calmodulin and calcium. Seems to act as a chaperone for BCL2, targets it to the mitochondria and modulates its phosphorylation state. The BCL2/FKBP8/calmodulin/calcium complex probably interferes with the binding of BCL2 to its targets. The active form of FKBP8 may therefore play a role in the regulation of apoptosis |
| GO Classification
|
| Function |
| binding |
| Process |
| protein folding |
| protein metabolic process |
| metabolic process |
| macromolecule metabolic process |
| cellular protein metabolic process |
|
| Cellular Location
|
- Mitochondrion membrane
- Cytoplasmic side
- Single-pass membrane protein
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 19p12 |
| SNPs
| FKBP8 |
| Gene Sequence
|
>1239 bp
ATGGCATCGTGTGCTGAACCCTCTGAGCCCTCTGCCCCACTGCCCGCCGGGGTCCCACCG
CTCGAGGACTTCGAGGTACTGGATGGGGTTGAGGATGCAGAGGGTGAGGAGGAAGAGGAG
GAGGAAGAGGAGGAAGAGGATGACCTGAGTGAGCTGCCACCGCTGGAGGACATGGGACAA
CCCCCGGCGGAGGAGGCTGAGCAGCCTGGGGCCCTGGCCCGAGAGTTCCTTGCTGCCATG
GAGCCCGAGCCCGCCCCAGCCCCGGCCCCAGAAGAGTGGCTGGACATTCTGGGGAACGGG
CTGTTGAGGAAGAAGACGCTGGTCCCAGGGCCGCCAGGTTCGAGCCGCCCGGTCAAGGGC
CAGGTGGTCACCGTACATCTGCAGACGTCGCTGGAGAATGGCACACGGGTGCAGGAGGAG
CCGGAGCTGGTGTTCACTCTGGGTGACTGTGACGTCATCCAGGCCCTGGATCTCAGTGTC
CCACTCATGGACGTGGGGGAGACGGCCATGGTCACTGCTGACTCCAAGTACTGCTACGGC
CCCCAAGGCAGGAGCCCATACATCCCCCCGCACGCGGCCCTGTGCCTGGAGGTGACCCTG
AAGACGGCTGTGGACGGGCCTGACCTGGAGATGCTCACGGGGCAGGAGCGCGTGGCCCTG
GCCAACCGGAAGCGGGAGTGCGGCAACGCCCACTACCAGCGGGCGGACTTCGTCCTGGCC
GCCAACTCCTACGACCTCGCCATCAAGGCTATCACCTCCAGCGCCAAAGTGGACATGACG
TTCGAGGAGGAGGCACAGCTCCTGCAGTTGAAGGTGAAGTGTCTGAACAACCTGGCGGCC
TCGCAGCTGAAGCTCGACCACTACCGCGCAGCCCTGCGCTCCTGCAGCCTTGTGCTGGAG
CACCAGCCAGACAACATCAAGGCTCTCTTCCGCAAGGGCAAGGTGCTGGCCCAGCAGGGG
GAGTACAGTGAGGCCATCCCCATCCTGAGGGCAGCCCTGAAGCTGGAACCTTCCAACAAG
ACGATCCACGCAGAGCTCTCAAAGCTGGTGAAGAAGCATGCGGCGCAGCGGAGCACGGAG
ACCGCCTTGTACCGGAAAATGCTGGGCAACCCCAGCCGGCTGCCTGCTAAGTGCCCTGGC
AAGGGTGCCTGGTCCATCCCATGGAAGTGGCTGTTTGGGGCGACTGCTGTTGCCTTGGGG
GGTGTGGCACTCTCTGTGGTCATCGCTGCCAGGAACTGA
|
| Protein Properties |
|---|
| Number of Residues
| 412 |
| Molecular Weight
| 44561.3 |
| Theoretical pI
| 4.49 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Peptidyl-prolyl cis-trans isomerase FKBP8
MASCAEPSEPSAPLPAGVPPLEDFEVLDGVEDAEGEEEEEEEEEEEDDLSELPPLEDMGQ
PPAEEAEQPGALAREFLAAMEPEPAPAPAPEEWLDILGNGLLRKKTLVPGPPGSSRPVKG
QVVTVHLQTSLENGTRVQEEPELVFTLGDCDVIQALDLSVPLMDVGETAMVTADSKYCYG
PQGRSPYIPPHAALCLEVTLKTAVDGPDLEMLTGQERVALANRKRECGNAHYQRADFVLA
ANSYDLAIKAITSSAKVDMTFEEEAQLLQLKVKCLNNLAASQLKLDHYRAALRSCSLVLE
HQPDNIKALFRKGKVLAQQGEYSEAIPILRAALKLEPSNKTIHAELSKLVKKHAAQRSTE
TALYRKMLGNPSRLPAKCPGKGAWSIPWKWLFGATAVALGGVALSVVIAARN
|
| External Links |
|---|
| GenBank ID Protein
| 28395543 |
| UniProtKB/Swiss-Prot ID
| Q14318 |
| UniProtKB/Swiss-Prot Entry Name
| FKBP8_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AY225339 |
| GeneCard ID
| FKBP8 |
| GenAtlas ID
| FKBP8 |
| HGNC ID
| HGNC:3724 |
| References |
|---|
| General References
| Not Available |