| Identification |
|---|
| HMDB Protein ID
| CDBP02897 |
| Secondary Accession Numbers
| Not Available |
| Name
| F-box only protein 43 |
| Description
| Not Available |
| Synonyms
|
- Endogenous meiotic inhibitor 2
|
| Gene Name
| FBXO43 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in zinc ion binding |
| Specific Function
| Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Probably acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (Probable) |
| GO Classification
|
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| transition metal ion binding |
| zinc ion binding |
|
| Cellular Location
|
Not Available
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:8 |
| Locus
| 8q22.2 |
| SNPs
| FBXO43 |
| Gene Sequence
|
>2127 bp
ATGAGTTTTAAAGACAAAGATGAGAGAATTTCTTGTTTGGAAGCCTACGTAACTTTGACA
TCTAAGAGCTCAAGATTTACTGATGAAACAGAGATTTTGAAGATGTCGCAAAGGCACTCA
GGTCAAGCTGGCACTGAAGCAGGAAATGGGGCGGACTCTCCTCCAATTGTCAACTCCAAG
TACTCCACCTTCAGAGATTTTTGTTCCACATCTTCATTTCAAGATAGTGGCTACAATGAG
TTAAAATCTTGTAGCTTTGATAATATAGATAAAGAATATCTTGGAAAGAAAGAAAAAGGC
CCAACATTACTCTATGAGCACCCTGAAACTTCAGGCCTGGGCTTAACACATCCTTTAGAA
TCTCCCACTCAAAAAAAGAAATGTATCTTGCCTAGAAAGGAAAAGGATAAAACCCCAGAA
CTTTGTGAAACACCTAAAATCAGTGGGAAAAAATGTTTACCTCGCAGAAGGTTGAATGTA
TCTTTCGCTCTTCTAAAAGGGGACTTTGAATCACAAAATAGTTCTTTAGAAAGTAGTATA
AGCCAAGTTATCAACTTAGAAAAAAATATTCCAAGCAGTGCTTCAGGTTTTTCCAGGGCA
AATAATTTTAGCCCTTTAGTTACTAGCACTTTAAAAACAGAAGAAGTGACTTCATGCAGT
CAAAAATTGAGGCTTAATTTTTCTCAGCAAAAGACTTCCACAATTGATGATTCCAAAGAT
GATTGTAGCCTATTTGAAGTTGAATGTATATCTCCAATTCAGGGCAATAATTTTAAAGAC
TCTATCACACATGACTTTAGTGATAGCAGTTTATGCATTAATGATGAGAATGCATGTCCA
GAGCTCCTGGGCTCCTCTGTTAGTGGAACAACTTGTGGAACAGATGAGGACATATTTGTG
ACTCCGATAAGTAATCTTGTGGCAAACATTAGATTTAACGCAAGTCAAATACTTTCTCCT
TCACCTGAAGTGAGAGGCAGTATTTCAACGCCTGAAGACAGTGGTTTTAACTCACTTAGC
TTGGAGAAATCAGAAGATTCCCTGTCTGACCAGGAGGGTTCTTTTCAAGAACTACTGCAG
AAACATAAGGGGACTCCCAAAGTTGGGGACACCATAAGAAAGACAAGACATCTTGGAAGG
TCGAGAAGACTGTCCACCCTTCGGGAACAAAGCTCGCAGTCAGAGACAGAAGAGGAAAAG
CAGATTGTCCACCCTGACTCTGAAAAAAGAGCAGCAGCTGCTTCTGCCATCTCAGAGGGT
CAGCTGAGTAGTGATGAGAGTGGGGATTTGACCTTTAGCTTAAAGAATTTATCAAAGACC
CCAGCCTTGCAATTGGTACATGAGCTGTTCATGAAAAGCAAGAGGAAAAGATTACAGGAA
AATAGTGGACATGAATTCTTAGAGCAAGGGGATGGGGAGAAAATAGCTGTACTGCAGTGT
ATACTTGCAGGACTGATCGGCAAGAAAATGGGTATAGAAAAACTGGACATCTTAACAGAA
TTAAAATATAGAAATTTAAAGCATATTCTTGCTATGGTTTTAGAGTCCTTGACCGCAGAG
AGCCTATGCAGTGTTTGGAAAGTAAGCAGAAATTGGCGTGAAATTGTTGTTCAAGATAAA
AATGCAAATCGGAGGAGGAAATTTTATATCACACAACTGAAAACAGATTCTGAGGGGGCT
GTATTAAATGTCGAGGATGCTGCCACTCGGCTCCAGCTTTTAAATCGCTCAGCTTTAAGA
TCTGTGCAGGCACAGGCTAGGATACCTGGTTCTCAGAGAGAGCAAGGGTCAACATTATCT
CCCTGGGGAGAAGTTTTGACACCTCTAGCAAGCTCTTCTGTTACTCACTTAAGTAGTAAA
CAGGAAGAATATGTTAAGGTTGCCAAAACACTTTTTACTGATGAAGCATTAAAACCTTGC
CCAAGGTGCCAGTCCCCTGCTAAGTACCAGCCATATAAGAAAAGGGGACTGTGTAGCCGA
ACAGCCTGTGGTTTTGACTTTTGTGTGTTATGTCTGTGTGCTTATCATGGGTCTGAAGAA
TGTAGTAGAGGAGCAGCAAAGCCAAGAAATAGAAAAGATGCTCTCCCAGGAAGTGCCCAG
AGTAAGCGGAATTTAAAACGCCTCTGA
|
| Protein Properties |
|---|
| Number of Residues
| 708 |
| Molecular Weight
| 78401.5 |
| Theoretical pI
| 8.15 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>F-box only protein 43
MSFKDKDERISCLEAYVTLTSKSSRFTDETEILKMSQRHSGQAGTEAGNGADSPPIVNSK
YSTFRDFCSTSSFQDSGYNELKSCSFDNIDKEYLGKKEKGPTLLYEHPETSGLGLTHPLE
SPTQKKKCILPRKEKDKTPELCETPKISGKKCLPRRRLNVSFALLKGDFESQNSSLESSI
SQVINLEKNIPSSASGFSRANNFSPLVTSTLKTEEVTSCSQKLRLNFSQQKTSTIDDSKD
DCSLFEVECISPIQGNNFKDSITHDFSDSSLCINDENACPELLGSSVSGTTCGTDEDIFV
TPISNLVANIRFNASQILSPSPEVRGSISTPEDSGFNSLSLEKSEDSLSDQEGSFQELLQ
KHKGTPKVGDTIRKTRHLGRSRRLSTLREQSSQSETEEEKQIVHPDSEKRAAAASAISEG
QLSSDESGDLTFSLKNLSKTPALQLVHELFMKSKRKRLQENSGHEFLEQGDGEKIAVLQC
ILAGLIGKKMGIEKLDILTELKYRNLKHILAMVLESLTAESLCSVWKVSRNWREIVVQDK
NANRRRKFYITQLKTDSEGAVLNVEDAATRLQLLNRSALRSVQAQARIPGSQREQGSTLS
PWGEVLTPLASSSVTHLSSKQEEYVKVAKTLFTDEALKPCPRCQSPAKYQPYKKRGLCSR
TACGFDFCVLCLCAYHGSEECSRGAAKPRNRKDALPGSAQSKRNLKRL
|
| External Links |
|---|
| GenBank ID Protein
| 117606351 |
| UniProtKB/Swiss-Prot ID
| Q4G163 |
| UniProtKB/Swiss-Prot Entry Name
| FBX43_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001029860.3 |
| GeneCard ID
| FBXO43 |
| GenAtlas ID
| FBXO43 |
| HGNC ID
| HGNC:28521 |
| References |
|---|
| General References
| Not Available |