| Identification |
|---|
| HMDB Protein ID
| CDBP02876 |
| Secondary Accession Numbers
| Not Available |
| Name
| Desmoglein-4 |
| Description
| Not Available |
| Synonyms
|
- Cadherin family member 13
|
| Gene Name
| DSG4 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion. Coordinates the transition from proliferation to differentiation in hair follicle keratinocytes |
| GO Classification
|
| Component |
| membrane |
| cell part |
| plasma membrane |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| calcium ion binding |
| Process |
| cell adhesion |
| cellular process |
| cell-cell adhesion |
| homophilic cell adhesion |
|
| Cellular Location
|
- Cell membrane
- Single-pass type I membrane protein
- Cell junction
- desmosome
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 18q12.1 |
| SNPs
| DSG4 |
| Gene Sequence
|
>3123 bp
ATGGATTGGCTCTTCTTCAGAAACATTTGCCTTTTGATCATTCTAATGGTGGTGATGGAA
GTAAACAGTGAATTTATTGTTGAGGTGAAGGAATTTGACATTGAAAATGGCACTACAAAA
TGGCAAACAGTCAGAAGACAAAAGCGGGAGTGGATCAAGTTTGCCGCAGCCTGTCGAGAA
GGAGAGGACAACTCGAAGAGGAACCCCATTGCCAAAATTCGATCAGACTGCGAATCGAAC
CAGAAGATAACATACCGGATTTCTGGAGTAGGGATTGATCGACCACCATATGGGGTATTC
ACCATTAATCCTCGCACTGGGGAAATTAACATCACTTCAGTGGTAGACAGAGAAATAACT
CCACTTTTCTTGATCTATTGCCGGGCTCTGAATTCACGGGGTGAAGATTTAGAAAGGCCT
CTTGAGCTTAGAGTCAAAGTTATGGACATAAATGATAACGCTCCAGTCTTTTCGCAAAGT
GTATACACAGCCAGCATTGAAGAAAATAGTGATGCCAATACATTGGTAGTAAAGTTATGT
GCCACAGATGCAGATGAAGAAAATCATCTGAATTCTAAAATTGCCTACAAGATCGTCTCT
CAGGAGCCATCAGGTGCACCCATGTTCATTCTGAATAGGTACACTGGAGAAGTCTGCACC
ATGTCCAGTTTCTTGGACAGAGAGCAACACAGTATGTACAACCTGGTTGTGAGAGGCTCA
GATCGGGATGGAGCTGCAGATGGACTGTCTTCTGAGTGTGACTGTAGAATCAAGGTTTTA
GACGTCAACGATAATTTCCCCACCTTAGAGAAAACTTCATACTCAGCCAGTATTGAAGAG
AATTGTTTAAGTTCGGAACTGATACGATTACAAGCAATTGATCTTGATGAAGAAGGCACT
GATAACTGGTTGGCTCAATATTTAATTCTCTCTGGAAATGATGGGAATTGGTTCGATATT
CAAACAGATCCACAAACCAATGAAGGCATTTTGAAAGTTGTCAAGATGCTGGATTATGAA
CAAGCACCTAACATTCAGCTTAGTATCGGAGTTAAAAACCAAGCTGATTTTCACTACTCC
GTTGCTTCTCAATTCCAAATGCACCCAACCCCTGTGAGAATTCAAGTTGTTGATGTGAGA
GAAGGACCTGCATTTCATCCAAGTACTATGGCTTTTAGTGTGCGGGAAGGAATAAAAGGA
AGTTCCTTATTGAATTATGTGCTTGGCACATATACAGCCATAGATTTGGACACAGGAAAC
CCTGCAACAGATGTCAGATATATCATAGGGCATGATGCAGGCAGCTGGTTAAAAATTGAT
TCAAGAACTGGTGAGATACAATTTTCTAGAGAATTTGATAAGAAGTCAAAATATATTATC
AATGGGATATACACAGCAGAGATCCTGGCTATAGATGATGGCTCTGGAAAAACAGCTACA
GGAACCATATGTATTGAGGTTCCTGATATCAATGATTATTGTCCAAACATTTTTCCTGAA
AGAAGAACCATCTGCATTGACTCTCCATCAGTCCTTATCTCTGTTAATGAACATTCTTAT
GGGTCTCCGTTTACTTTCTGTGTTGTTGATGAGCCACCAGGAATAGCTGACATGTGGGAT
GTCAGATCAACAAATGCTACCTCGGCAATCCTTACGGCTAAGCAGGTTTTATCTCCAGGA
TTTTATGAAATCCCAATCCTGGTGAAGGACAGCTATAACAGAGCATGTGAATTGGCACAA
ATGGTGCAGTTATATGCCTGTGATTGCGATGACAACCACATGTGCCTGGACTCTGGTGCC
GCGGGCATCTACACAGAGGACATAACTGGTGACACGTATGGGCCTGTCACTGAAGACCAA
GCTGGAGTTTCAAATGTTGGTCTTGGACCAGCAGGGATTGGCATGATGGTTCTGGGCATC
CTGCTACTGATTTTGGCTCCACTCTTGCTGCTCCTGTGTTGCTGCAAACAGAGACAGCCA
GAAGGCCTGGGAACAAGATTTGCTCCTGTGCCTGAGGGCGGAGAAGGAGTGATGCAGTCT
TGGAGAATTGAAGGGGCCCATCCCGAGGACAGGGATGTGTCAAATATATGTGCACCCATG
ACAGCCTCAAATACCCAGGATCGGATGGATTCCTCTGAAATCTACACCAACACCTATGCA
GCCGGGGGCACGGTGGAAGGAGGTGTATCGGGAGTGGAGCTCAACACAGGTATGGGGACA
GCCGTTGGCCTCATGGCCGCAGGGGCCGCAGGAGCCTCAGGGGCCGCAAGGAAGAGGAGC
TCTACCATGGGAACCCTGCGGGACTACGCTGACGCAGACATCAACATGGCTTTCTTGGAC
AGCTACTTCTCGGAGAAAGCGTATGCTTATGCAGATGAAGATGAAGGTCGACCAGCCAAT
GACTGCTTGCTCATTTATGACCACGAGGGAGTCGGGTCTCCCGTAGGCTCTATTGGTTGT
TGCAGTTGGATTGTGGATGACTTAGATGAAAGCTGCATGGAAACTTTAGATCCAAAATTT
AGGACTCTTGCTGAGATCTGCTTAAACACAGAAATTGAACCATTTCCTTCACACCAGGCT
TGTATACCAATCAGTACTGACCTCCCTTTGCTCGGACCTAATTACTTTGTTAATGAATCT
TCAGGATTGACTCCCTCAGAAGTTGAATTCCAAGAAGAAATGGCAGCATCTGAACCCGTG
GTCCATGGGGATATTATTGTGACTGAGACTTACGGTAATGCTGATCCATGTGTGCAACCC
ACTACAATTATTTTTGATCCTCAGCTTGCACCCAATGTTGTAGTAACCGAAGCAGTAATG
GCACCTGTCTATGATATTCAAGGGAATATTTGTGTACCTGCTGAGTTAGCAGATTACAAC
AATGTAATCTATGCTGAGAGAGTACTGGCTAGTCCTGGTGTGCCTGACATGAGCAATAGT
AGCACGACTGAGGGTTGTATGGGACCTGTGATGAGCGGCAATATTTTAGTAGGGCCAGAA
ATTCAAGTGATGCAAATGATGAGTCCAGACCTTCCCATAGGCCAAACCGTTGGCTCCACA
TCCCCCATGACATCTCGACACAGAGTAACACGATACAGTAACATACATTACACCCAACAG
TAA
|
| Protein Properties |
|---|
| Number of Residues
| 1040 |
| Molecular Weight
| 113823.1 |
| Theoretical pI
| 4.17 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Desmoglein-4
MDWLFFRNICLLIILMVVMEVNSEFIVEVKEFDIENGTTKWQTVRRQKREWIKFAAACRE
GEDNSKRNPIAKIRSDCESNQKITYRISGVGIDRPPYGVFTINPRTGEINITSVVDREIT
PLFLIYCRALNSRGEDLERPLELRVKVMDINDNAPVFSQSVYTASIEENSDANTLVVKLC
ATDADEENHLNSKIAYKIVSQEPSGAPMFILNRYTGEVCTMSSFLDREQHSMYNLVVRGS
DRDGAADGLSSECDCRIKVLDVNDNFPTLEKTSYSASIEENCLSSELIRLQAIDLDEEGT
DNWLAQYLILSGNDGNWFDIQTDPQTNEGILKVVKMLDYEQAPNIQLSIGVKNQADFHYS
VASQFQMHPTPVRIQVVDVREGPAFHPSTMAFSVREGIKGSSLLNYVLGTYTAIDLDTGN
PATDVRYIIGHDAGSWLKIDSRTGEIQFSREFDKKSKYIINGIYTAEILAIDDGSGKTAT
GTICIEVPDINDYCPNIFPERRTICIDSPSVLISVNEHSYGSPFTFCVVDEPPGIADMWD
VRSTNATSAILTAKQVLSPGFYEIPILVKDSYNRACELAQMVQLYACDCDDNHMCLDSGA
AGIYTEDITGDTYGPVTEDQAGVSNVGLGPAGIGMMVLGILLLILAPLLLLLCCCKQRQP
EGLGTRFAPVPEGGEGVMQSWRIEGAHPEDRDVSNICAPMTASNTQDRMDSSEIYTNTYA
AGGTVEGGVSGVELNTGMGTAVGLMAAGAAGASGAARKRSSTMGTLRDYADADINMAFLD
SYFSEKAYAYADEDEGRPANDCLLIYDHEGVGSPVGSIGCCSWIVDDLDESCMETLDPKF
RTLAEICLNTEIEPFPSHQACIPISTDLPLLGPNYFVNESSGLTPSEVEFQEEMAASEPV
VHGDIIVTETYGNADPCVQPTTIIFDPQLAPNVVVTEAVMAPVYDIQGNICVPAELADYN
NVIYAERVLASPGVPDMSNSSTTEGCMGPVMSGNILVGPEIQVMQMMSPDLPIGQTVGST
SPMTSRHRVTRYSNIHYTQQ
|
| External Links |
|---|
| GenBank ID Protein
| 29789445 |
| UniProtKB/Swiss-Prot ID
| Q86SJ6 |
| UniProtKB/Swiss-Prot Entry Name
| DSG4_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_177986.3 |
| GeneCard ID
| DSG4 |
| GenAtlas ID
| DSG4 |
| HGNC ID
| HGNC:21307 |
| References |
|---|
| General References
| Not Available |