| Identification |
|---|
| HMDB Protein ID
| CDBP02875 |
| Secondary Accession Numbers
| Not Available |
| Name
| Desmoglein-3 |
| Description
| Not Available |
| Synonyms
|
- 130 kDa pemphigus vulgaris antigen
- Cadherin family member 6
- PVA
|
| Gene Name
| DSG3 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion |
| GO Classification
|
| Component |
| membrane |
| cell part |
| plasma membrane |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| calcium ion binding |
| Process |
| cell adhesion |
| cellular process |
| cell-cell adhesion |
| homophilic cell adhesion |
|
| Cellular Location
|
- Cell membrane
- Single-pass type I membrane protein
- Cell junction
- desmosome
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 18q12.1 |
| SNPs
| DSG3 |
| Gene Sequence
|
>3000 bp
ATGATGGGGCTCTTCCCCAGAACTACAGGGGCTCTGGCCATCTTCGTGGTGGTCATATTG
GTTCATGGAGAATTGCGAATAGAGACTAAAGGTCAATATGATGAAGAAGAGATGACTATG
CAACAAGCTAAAAGAAGGCAAAAACGTGAATGGGTGAAATTTGCCAAACCCTGCAGAGAA
GGAGAAGATAACTCAAAAAGAAACCCAATTGCCAAGATTACTTCAGATTACCAAGCAACC
CAGAAAATCACCTACCGAATCTCTGGAGTGGGAATCGATCAGCCGCCTTTTGGAATCTTT
GTTGTTGACAAAAACACTGGAGATATTAACATAACAGCTATAGTCGACCGGGAGGAAACT
CCAAGCTTCCTGATCACATGTCGGGCTCTAAATGCCCAAGGACTAGATGTAGAGAAACCA
CTTATACTAACGGTTAAAATTTTGGATATTAATGATAATCCTCCAGTATTTTCACAACAA
ATTTTCATGGGTGAAATTGAAGAAAATAGTGCCTCAAACTCACTGGTGATGATACTAAAT
GCCACAGATGCAGATGAACCAAACCACTTGAATTCTAAAATTGCCTTCAAAATTGTCTCT
CAGGAACCAGCAGGCACACCCATGTTCCTCCTAAGCAGAAACACTGGGGAAGTCCGTACT
TTGACCAATTCTCTTGACCGAGAGCAAGCTAGCAGCTATCGTCTGGTTGTGAGTGGTGCA
GACAAAGATGGAGAAGGACTATCAACTCAATGTGAATGTAATATTAAAGTGAAAGATGTC
AACGATAACTTCCCAATGTTTAGAGACTCTCAGTATTCAGCACGTATTGAAGAAAATATT
TTAAGTTCTGAATTACTTCGATTTCAAGTAACAGATTTGGATGAAGAGTACACAGATAAT
TGGCTTGCAGTATATTTCTTTACCTCTGGGAATGAAGGAAATTGGTTTGAAATACAAACT
GATCCTAGAACTAATGAAGGCATCCTGAAAGTGGTGAAGGCTCTAGATTATGAACAACTA
CAAAGCGTGAAACTTAGTATTGCTGTCAAAAACAAAGCTGAATTTCACCAATCAGTTATC
TCTCGATACCGAGTTCAGTCAACCCCAGTCACAATTCAGGTAATAAATGTAAGAGAAGGA
ATTGCATTCCGTCCTGCTTCCAAGACATTTACTGTGCAAAAAGGCATAAGTAGCAAAAAA
TTGGTGGATTATATCCTGGGAACATATCAAGCCATCGATGAGGACACTAACAAAGCTGCC
TCAAATGTCAAATATGTCATGGGACGTAACGATGGTGGATACCTAATGATTGATTCAAAA
ACTGCTGAAATCAAATTTGTCAAAAATATGAACCGAGATTCTACTTTCATAGTTAACAAA
ACAATCACAGCTGAGGTTCTGGCCATAGATGAATACACGGGTAAAACTTCTACAGGCACG
GTATATGTTAGAGTACCCGATTTCAATGACAATTGTCCAACAGCTGTCCTCGAAAAAGAT
GCAGTTTGCAGTTCTTCACCTTCCGTGGTTGTCTCCGCTAGAACACTGAATAATAGATAC
ACTGGCCCCTATACATTTGCACTGGAAGATCAACCTGTAAAGTTGCCTGCCGTATGGAGT
ATCACAACCCTCAATGCTACCTCGGCCCTCCTCAGAGCCCAGGAACAGATACCTCCTGGA
GTATACCACATCTCCCTGGTACTTACAGACAGTCAGAACAATCGGTGTGAGATGCCACGC
AGCTTGACACTGGAAGTCTGTCAGTGTGACAACAGGGGCATCTGTGGAACTTCTTACCCA
ACCACAAGCCCTGGGACCAGGTATGGCAGGCCGCACTCAGGGAGGCTGGGGCCTGCCGCC
ATCGGCCTGCTGCTCCTTGGTCTCCTGCTGCTGCTGTTGGCCCCCCTTCTGCTGTTGACC
TGTGACTGTGGGGCAGGTTCTACTGGGGGAGTGACAGGTGGTTTTATCCCAGTTCCTGAT
GGCTCAGAAGGAACAATTCATCAGTGGGGAATTGAAGGAGCCCATCCTGAAGACAAGGAA
ATCACAAATATTTGTGTGCCTCCTGTAACAGCCAATGGAGCCGATTTCATGGAAAGTTCT
GAAGTTTGTACAAATACGTATGCCAGAGGCACAGCGGTGGAAGGCACTTCAGGAATGGAA
ATGACCACTAAGCTTGGAGCAGCCACTGAATCTGGAGGTGCTGCAGGCTTTGCAACAGGG
ACAGTGTCAGGAGCTGCTTCAGGATTCGGAGCAGCCACTGGAGTTGGCATCTGTTCCTCA
GGGCAGTCTGGAACCATGAGAACAAGGCATTCCACTGGAGGAACCAATAAGGACTACGCT
GATGGGGCGATAAGCATGAATTTTCTGGACTCCTACTTTTCTCAGAAAGCATTTGCCTGT
GCGGAGGAAGACGATGGCCAGGAAGCAAATGACTGCTTGTTGATCTATGATAATGAAGGC
GCAGATGCCACTGGTTCTCCTGTGGGCTCCGTGGGTTGTTGCAGTTTTATTGCTGATGAC
CTGGATGACAGCTTCTTGGACTCACTTGGACCCAAATTTAAAAAACTTGCAGAGATAAGC
CTTGGTGTTGATGGTGAAGGCAAAGAAGTTCAGCCACCCTCTAAAGACAGCGGTTATGGG
ATTGAATCCTGTGGCCATCCCATAGAAGTCCAGCAGACAGGATTTGTTAAGTGCCAGACT
TTGTCAGGAAGTCAAGGAGCTTCTGCTTTGTCCACCTCTGGGTCTGTCCAGCCAGCTGTT
TCCATCCCTGACCCTCTGCAGCATGGTAACTATTTAGTAACGGAGACTTACTCGGCTTCT
GGTTCCCTCGTGCAACCTTCCACTGCAGGCTTTGATCCACTTCTCACACAAAATGTGATA
GTGACAGAAAGGGTGATCTGTCCCATTTCCAGTGTTCCTGGCAACCTAGCTGGCCCAACG
CAGCTACGAGGGTCACATACTATGCTCTGTACAGAGGATCCTTGCTCCCGTCTAATATGA
|
| Protein Properties |
|---|
| Number of Residues
| 999 |
| Molecular Weight
| 107532.1 |
| Theoretical pI
| 4.61 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Desmoglein-3
MMGLFPRTTGALAIFVVVILVHGELRIETKGQYDEEEMTMQQAKRRQKREWVKFAKPCRE
GEDNSKRNPIAKITSDYQATQKITYRISGVGIDQPPFGIFVVDKNTGDINITAIVDREET
PSFLITCRALNAQGLDVEKPLILTVKILDINDNPPVFSQQIFMGEIEENSASNSLVMILN
ATDADEPNHLNSKIAFKIVSQEPAGTPMFLLSRNTGEVRTLTNSLDREQASSYRLVVSGA
DKDGEGLSTQCECNIKVKDVNDNFPMFRDSQYSARIEENILSSELLRFQVTDLDEEYTDN
WLAVYFFTSGNEGNWFEIQTDPRTNEGILKVVKALDYEQLQSVKLSIAVKNKAEFHQSVI
SRYRVQSTPVTIQVINVREGIAFRPASKTFTVQKGISSKKLVDYILGTYQAIDEDTNKAA
SNVKYVMGRNDGGYLMIDSKTAEIKFVKNMNRDSTFIVNKTITAEVLAIDEYTGKTSTGT
VYVRVPDFNDNCPTAVLEKDAVCSSSPSVVVSARTLNNRYTGPYTFALEDQPVKLPAVWS
ITTLNATSALLRAQEQIPPGVYHISLVLTDSQNNRCEMPRSLTLEVCQCDNRGICGTSYP
TTSPGTRYGRPHSGRLGPAAIGLLLLGLLLLLLAPLLLLTCDCGAGSTGGVTGGFIPVPD
GSEGTIHQWGIEGAHPEDKEITNICVPPVTANGADFMESSEVCTNTYARGTAVEGTSGME
MTTKLGAATESGGAAGFATGTVSGAASGFGAATGVGICSSGQSGTMRTRHSTGGTNKDYA
DGAISMNFLDSYFSQKAFACAEEDDGQEANDCLLIYDNEGADATGSPVGSVGCCSFIADD
LDDSFLDSLGPKFKKLAEISLGVDGEGKEVQPPSKDSGYGIESCGHPIEVQQTGFVKCQT
LSGSQGASALSTSGSVQPAVSIPDPLQHGNYLVTETYSASGSLVQPSTAGFDPLLTQNVI
VTERVICPISSVPGNLAGPTQLRGSHTMLCTEDPCSRLI
|
| External Links |
|---|
| GenBank ID Protein
| 119964718 |
| UniProtKB/Swiss-Prot ID
| P32926 |
| UniProtKB/Swiss-Prot Entry Name
| DSG3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_001944.2 |
| GeneCard ID
| DSG3 |
| GenAtlas ID
| DSG3 |
| HGNC ID
| HGNC:3050 |
| References |
|---|
| General References
| Not Available |