| Identification |
|---|
| HMDB Protein ID
| CDBP02867 |
| Secondary Accession Numbers
| Not Available |
| Name
| Deoxyribonuclease gamma |
| Description
| Not Available |
| Synonyms
|
- DNase I homolog protein DHP2
- DNase I-like 3
- DNase gamma
- Deoxyribonuclease I-like 3
- LS-DNase
- LSD
- Liver and spleen DNase
|
| Gene Name
| DNASE1L3 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in deoxyribonuclease activity |
| Specific Function
| Has DNA hydrolytic activity. Does not bind to actin. Cleaves chromatin DNA to nucleosomal units |
| GO Classification
|
| Function |
| hydrolase activity, acting on ester bonds |
| catalytic activity |
| hydrolase activity |
| nuclease activity |
| deoxyribonuclease activity |
| Process |
| metabolic process |
| macromolecule metabolic process |
| cellular macromolecule metabolic process |
| dna metabolic process |
| dna catabolic process |
|
| Cellular Location
|
- Nucleus
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:3 |
| Locus
| 3p14.3 |
| SNPs
| DNASE1L3 |
| Gene Sequence
|
>918 bp
ATGTCACGGGAGCTGGCCCCACTGCTGCTTCTCCTCCTCTCCATCCACAGCGCCCTGGCC
ATGAGGATCTGCTCCTTCAACGTCAGGTCCTTTGGGGAAAGCAAGCAGGAAGACAAGAAT
GCCATGGATGTCATTGTGAAGGTCATCAAACGCTGTGACATCATACTCGTGATGGAAATC
AAGGACAGCAACAACAGGATCTGCCCCATACTGATGGAGAAGCTGAACAGAAATTCAAGG
AGAGGCATAACGTACAACTATGTGATTAGCTCTCGGCTTGGAAGAAACACATATAAAGAA
CAATATGCCTTTCTCTACAAGGAAAAGCTGGTGTCTGTGAAGAGGAGTTATCACTACCAT
GACTATCAGGATGGAGACGCAGATGTGTTTTCCAGGGAGCCCTTTGTGGTCTGGTTCCAA
TCTCCCCACACTGCTGTCAAAGACTTCGTGATTATCCCCCTGCACACCACCCCAGAGACA
TCCGTTAAGGAGATCGATGAGTTGGTTGAGGTCTACACGGACGTGAAACACCGCTGGAAG
GCGGAGAATTTCATTTTCATGGGTGACTTCAATGCCGGCTGCAGCTACGTCCCCAAGAAG
GCCTGGAAGAACATCCGCTTGAGGACTGACCCCAGGTTTGTTTGGCTGATCGGGGACCAA
GAGGACACCACGGTGAAGAAGAGCACCAACTGTGCATATGACAGGATTGTGCTTAGAGGA
CAAGAAATCGTCAGTTCTGTTGTTCCCAAGTCAAACAGTGTTTTTGACTTCCAGAAAGCT
TACAAGCTGACTGAAGAGGAGGCCCTGGATGTCAGCGACCACTTTCCAGTTGAATTTAAA
CTACAGTCTTCAAGGGCCTTCACCAACAGCAAAAAATCTGTCACTCTAAGGAAGAAAACA
AAGAGCAAACGCTCCTAG
|
| Protein Properties |
|---|
| Number of Residues
| 305 |
| Molecular Weight
| 35503.5 |
| Theoretical pI
| 9.77 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Deoxyribonuclease gamma
MSRELAPLLLLLLSIHSALAMRICSFNVRSFGESKQEDKNAMDVIVKVIKRCDIILVMEI
KDSNNRICPILMEKLNRNSRRGITYNYVISSRLGRNTYKEQYAFLYKEKLVSVKRSYHYH
DYQDGDADVFSREPFVVWFQSPHTAVKDFVIIPLHTTPETSVKEIDELVEVYTDVKHRWK
AENFIFMGDFNAGCSYVPKKAWKNIRLRTDPRFVWLIGDQEDTTVKKSTNCAYDRIVLRG
QEIVSSVVPKSNSVFDFQKAYKLTEEEALDVSDHFPVEFKLQSSRAFTNSKKSVTLRKKT
KSKRS
|
| External Links |
|---|
| GenBank ID Protein
| 2905786 |
| UniProtKB/Swiss-Prot ID
| Q13609 |
| UniProtKB/Swiss-Prot Entry Name
| DNSL3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF047354 |
| GeneCard ID
| DNASE1L3 |
| GenAtlas ID
| DNASE1L3 |
| HGNC ID
| HGNC:2959 |
| References |
|---|
| General References
| Not Available |