| Identification |
|---|
| HMDB Protein ID
| CDBP02864 |
| Secondary Accession Numbers
| Not Available |
| Name
| Dentin matrix acidic phosphoprotein 1 |
| Description
| Not Available |
| Synonyms
|
- DMP-1
- Dentin matrix protein 1
|
| Gene Name
| DMP1 |
| Protein Type
| Enzyme |
| Biological Properties |
|---|
| General Function
| Involved in ossification |
| Specific Function
| May have a dual function during osteoblast differentiation. In the nucleus of undifferentiated osteoblasts, unphosphorylated form acts as a transcriptional component for activation of osteoblast-specific genes like osteocalcin. During the osteoblast to osteocyte transition phase it is phosphorylated and exported into the extracellular matrix, where it regulates nucleation of hydroxyapatite |
| GO Classification
|
| Process |
| multicellular organismal process |
| extracellular matrix organization |
| ossification |
| cellular process |
| cellular component organization at cellular level |
| extracellular structure organization |
|
| Cellular Location
|
- Nucleus
- Cytoplasm
- Secreted
- extracellular space
- extracellular matrix
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:4 |
| Locus
| 4q21 |
| SNPs
| DMP1 |
| Gene Sequence
|
>1542 bp
ATGAAGATCAGCATCCTGCTCATGTTCCTTTGGGGATTATCCTGTGCTCTCCCAGTAACC
AGGTATCAAAATAATGAATCTGAGGATTCTGAAGAATGGAAGGGTCATTTGGCTCAGGCA
CCAACACCACCCTTGGAGAGCAGTGAGTCATCAGAAGGCAGTAAAGTTAGCTCAGAGGAA
CAGGCAAATGAAGACCCCAGTGACAGCACTCAGTCAGAGGAGGGCCTGGGCTCTGATGAT
CATCAATACATTTATAGGCTAGCTGGTGGCTTCTCCAGGAGCACAGGAAAAGGAGGAGAT
GATAAAGATGACGATGAAGATGACAGTGGAGATGACACCTTTGGTGACGATGACAGTGGC
CCAGGGCCCAAAGACAGACAAGAAGGAGGAAACTCCAGACTGGGAAGTGATGAGGACTCT
GATGACACCATACAAGCCAGTGAAGAGAGTGCCCCACAAGGGCAAGACAGTGCCCAAGAT
ACCACCAGTGAGAGCAGGGAACTTGACAATGAGGACCGGGTGGACAGCAAGCCTGAGGGA
GGTGACTCCACTCAAGAGAGTGAGAGTGAAGAGCACTGGGTGGGAGGTGGCAGTGATGGG
GAGAGCAGCCATGGAGACGGCTCCGAGTTGGACGATGAGGGAATGCAGAGTGATGACCCA
GAGAGCATCAGGAGTGAAAGGGGAAACTCCAGAATGAACAGTGCAGGCATGAAATCAAAA
GAATCTGGAGAAAACAGTGAGCAAGCAAACACTCAAGATTCAGGTGGCAGCCAATTGCTG
GAGCATCCCAGTAGGAAAATTTTTAGGAAGTCTCGCATCTCAGAGGAAGATGACAGAAGC
GAGCTTGATGACAACAACACAATGGAAGAAGTCAAGAGTGACTCTACAGAAAACAGCAAC
TCCAGAGACACTGGCCTCAGCCAACCCAGGAGAGACAGCAAGGGTGACTCTCAAGAAGAC
AGCAAGGAGAATCTGTCCCAGGAAGAGAGCCAAAACGTAGATGGTCCCAGCAGTGAGTCC
AGCCAAGAGGCCAACCTGTCATCTCAAGAGAACAGCAGTGAGTCTCAGGAAGAGGTGGTG
AGTGAGTCCAGGGGAGATAACCCCGACCCCACAACTAGTTATGTAGAAGACCAGGAAGAC
AGTGACTCCAGCGAGGAGGACAGCTCGCACACACTCTCCCACTCAAAAAGTGAATCCAGA
GAGGAGCAAGCAGACAGTGAATCCAGTGAAAGCCTCAACTTCTCAGAGGAAAGCCCGGAG
TCCCCTGAGGATGAGAACAGCTCCAGCCAGGAGGGCCTCCAGTCTCACAGCAGCTCAGCA
GAGAGTCAGAGCGAGGAAAGCCATTCTGAGGAAGACGACAGTGACTCTCAAGACAGCAGC
AGATCCAAAGAAGATAGCAACTCCACGGAGAGCAAATCAAGCAGTGAGGAAGATGGCCAG
TTGAAAAACATTGAGATAGAGAGCCGGAAATTAACAGTTGATGCCTATCACAACAAACCC
ATTGGGGACCAAGATGACAATGACTGCCAAGACGGCTATTAG
|
| Protein Properties |
|---|
| Number of Residues
| 513 |
| Molecular Weight
| 55781.9 |
| Theoretical pI
| 3.76 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Dentin matrix acidic phosphoprotein 1
MKISILLMFLWGLSCALPVTRYQNNESEDSEEWKGHLAQAPTPPLESSESSEGSKVSSEE
QANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSG
PGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQDTTSESRELDNEDRVDSKPEG
GDSTQESESEEHWVGGGSDGESSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSK
ESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSN
SRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQEANLSSQENSSESQEEVV
SESRGDNPDPTTSYVEDQEDSDSSEEDSSHTLSHSKSESREEQADSESSESLNFSEESPE
SPEDENSSSQEGLQSHSSSAESQSEESHSEEDDSDSQDSSRSKEDSNSTESKSSSEEDGQ
LKNIEIESRKLTVDAYHNKPIGDQDDNDCQDGY
|
| External Links |
|---|
| GenBank ID Protein
| 120660278 |
| UniProtKB/Swiss-Prot ID
| Q13316 |
| UniProtKB/Swiss-Prot Entry Name
| DMP1_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| BC130581 |
| GeneCard ID
| DMP1 |
| GenAtlas ID
| DMP1 |
| HGNC ID
| HGNC:2932 |
| References |
|---|
| General References
| Not Available |