Showing Protein C-X-C chemokine receptor type 1 (CDBP02856)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP02856
Secondary Accession Numbers Not Available
Name C-X-C chemokine receptor type 1
Description Not Available
Synonyms
  1. CD181 antigen
  2. CDw128a
  3. CXC-R1
  4. CXCR-1
  5. High affinity interleukin-8 receptor A
  6. IL-8 receptor type 1
  7. IL-8R A
Gene Name CXCR1
Protein Type Receptor
Biological Properties
General Function Involved in G-protein coupled receptor protein signaling pathway
Specific Function Receptor to interleukin-8, which is a powerful neutrophils chemotactic factor. Binding of IL-8 to the receptor causes activation of neutrophils. This response is mediated via a G-protein that activate a phosphatidylinositol-calcium second messenger system. This receptor binds to IL-8 with a high affinity and to MGSA (GRO) with a low affinity
GO Classification
Component
cell part
membrane part
intrinsic to membrane
integral to membrane
Function
interleukin-8 receptor activity
receptor activity
transmembrane receptor activity
cytokine receptor activity
molecular transducer activity
signal transducer activity
Process
signaling pathway
cell surface receptor linked signaling pathway
g-protein coupled receptor protein signaling pathway
chemotaxis
response to stimulus
response to chemical stimulus
signaling
Cellular Location
  1. Cell membrane
  2. Multi-pass membrane protein
Pathways
Gene Properties
Chromosome Location Chromosome:2
Locus 2q35
SNPs CXCR1
Gene Sequence 
>1053 bp
ATGTCAAATATTACAGATCCACAGATGTGGGATTTTGATGATCTAAATTTCACTGGCATG
CCACCTGCAGATGAAGATTACAGCCCCTGTATGCTAGAAACTGAGACACTCAACAAGTAT
GTTGTGATCATCGCCTATGCCCTAGTGTTCCTGCTGAGCCTGCTGGGAAACTCCCTGGTG
ATGCTGGTCATCTTATACAGCAGGGTCGGCCGCTCCGTCACTGATGTCTACCTGCTGAAC
CTGGCCTTGGCCGACCTACTCTTTGCCCTGACCTTGCCCATCTGGGCCGCCTCCAAGGTG
AATGGCTGGATTTTTGGCACATTCCTGTGCAAGGTGGTCTCACTCCTGAAGGAAGTCAAC
TTCTACAGTGGCATCCTGCTGTTGGCCTGCATCAGTGTGGACCGTTACCTGGCCATTGTC
CATGCCACACGCACACTGACCCAGAAGCGTCACTTGGTCAAGTTTGTTTGTCTTGGCTGC
TGGGGACTGTCTATGAATCTGTCCCTGCCCTTCTTCCTTTTCCGCCAGGCTTACCATCCA
AACAATTCCAGTCCAGTTTGCTATGAGGTCCTGGGAAATGACACAGCAAAATGGCGGATG
GTGTTGCGGATCCTGCCTCACACCTTTGGCTTCATCGTGCCGCTGTTTGTCATGCTGTTC
TGCTATGGATTCACCCTGCGTACACTGTTTAAGGCCCACATGGGGCAGAAGCACCGAGCC
ATGAGGGTCATCTTTGCTGTCGTCCTCATCTTCCTGCTTTGCTGGCTGCCCTACAACCTG
GTCCTGCTGGCAGACACCCTCATGAGGACCCAGGTGATCCAGGAGAGCTGTGAGCGCCGC
AACAACATCGGCCGGGCCCTGGATGCCACTGAGATTCTGGGATTTCTCCATAGCTGCCTC
AACCCCATCATCTACGCCTTCATCGGCCAAAATTTTCGCCATGGATTCCTCAAGATCCTG
GCTATGCATGGCCTGGTCAGCAAGGAGTTCTTGGCACGTCATCGTGTTACCTCCTACACT
TCTTCGTCTGTCAATGTCTCTTCCAACCTCTGA
Protein Properties
Number of Residues 350
Molecular Weight 39790.7
Theoretical pI 8.81
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["40-66", "76-96", "112-133", "155-174", "200-220", "243-264", "286-308"]
Protein Sequence 
>C-X-C chemokine receptor type 1
MSNITDPQMWDFDDLNFTGMPPADEDYSPCMLETETLNKYVVIIAYALVFLLSLLGNSLV
MLVILYSRVGRSVTDVYLLNLALADLLFALTLPIWAASKVNGWIFGTFLCKVVSLLKEVN
FYSGILLLACISVDRYLAIVHATRTLTQKRHLVKFVCLGCWGLSMNLSLPFFLFRQAYHP
NNSSPVCYEVLGNDTAKWRMVLRILPHTFGFIVPLFVMLFCYGFTLRTLFKAHMGQKHRA
MRVIFAVVLIFLLCWLPYNLVLLADTLMRTQVIQESCERRNNIGRALDATEILGFLHSCL
NPIIYAFIGQNFRHGFLKILAMHGLVSKEFLARHRVTSYTSSSVNVSSNL
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P25024
UniProtKB/Swiss-Prot Entry Name CXCR1_HUMAN
PDB IDs Not Available
GenBank Gene ID L19591
GeneCard ID CXCR1
GenAtlas ID CXCR1
HGNC ID HGNC:6026
References
General References Not Available