Showing Protein Cation channel sperm-associated protein 4 (CDBP02855)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 compounds
Identification
HMDB Protein ID CDBP02855
Secondary Accession Numbers Not Available
Name Cation channel sperm-associated protein 4
Description Not Available
Synonyms
  1. CatSper4
Gene Name CATSPER4
Protein Type Transporter
Biological Properties
General Function Involved in ion channel activity
Specific Function Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization
GO Classification
Component
membrane
cell part
Function
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
transporter activity
ion channel activity
Process
establishment of localization
transport
transmembrane transport
ion transport
Cellular Location
  1. Multi-pass membrane protein
  2. Cell projection
  3. cilium
  4. flagellum membrane
Pathways
Gene Properties
Chromosome Location Chromosome:1
Locus 1p35.3
SNPs CATSPER4
Gene Sequence 
>1419 bp
ATGAGGGATAATGAAAAGGCCTGGTGGCAGCAATGGACCTCCCATACAGGCCTCGAGGGG
TGGGGCGGGACTCAGGAGGACCGTATGGGGTTTGGAGGGGCAGTAGCTGCACTGAGGGGC
CGCCCCTCTCCCCTGCAGAGTACCATTCACGAGTCCTACGGTCGGCCAGAGGAGCAAGTG
CTCATCAACCGCCAGGAAATCACGAACAAAGCGGACGCCTGGGACATGCAGGAGTTCATC
ACTCACATGTACATCAAGCAGCTGCTCCGACACCCCGCCTTCCAACTGCTGCTGGCCCTG
CTGCTGGTGATCAATGCCATCACCATCGCTCTCCGTACCAACTCCTACCTGGACCAGAAA
CACTATGAGTTGTTCTCTACCATAGATGACATTGTGCTGACCATCCTTCTTTGTGAGGTT
CTCCTTGGCTGGCTCAATGGCTTCTGGATTTTCTGGAAGGACGGCTGGAACATCCTCAAC
TTCATTATCGTCTTTATCTTGCTCTTGCGGTTCTTCATTAATGAAATCAATATTCCCTCC
ATCAACTACACTCTCAGGGCGCTTCGTCTGGTGCATGTGTGCATGGCGGTGGAGCCCCTC
GCCCGGATCATCCGCGTCATCCTGCAGTCGGTGCCTGACATGGCCAATATCATGGTCCTC
ATCCTCTTCTTCATGCTGGTTTTTTCCGTGTTTGGAGTAACACTCTTTGGTGCATTCGTG
CCCAAGCATTTCCAGAACATACAGGTTGCGCTGTACACCCTCTTCATCTGCATCACCCAG
GACGGCTGGGTGGACATCTACAGTGACTTCCAGACAGAGAAGAGGGAATATGCAATGGAG
ATTGGGGGTGCCATCTACTTTACCATCTTCATCACCATCGGTGCCTTCATTGGCATCAAC
CTGTTCGTCATCGTGGTGACCACCAACCTGGAGCAAATGATGAAGGCAGGAGAGCAGGGA
CAACAGCAACGAATAACCTTTAGTGAGACAGGCGCAGAGGAAGAGGAGGAGAATGACCAG
CTGCCACTGGTGCATTGTGTGGTCGCCCGCTCGGAGAAATCTGGTCTCCTCCAGGAACCC
CTTGCGGGAGGCCCCCTGTCGAACCTCTCAGAAAACACGTGTGACAACTTTTGCTTGGTG
CTTGAGGCAATACAGGAGAACCTGAGGCAGTACAAGGAGATCCGAGATGAACTCAACATG
ATTGTGGAGGAGGTGCGCGCAATCCGCTTCAACCAGGAGCAGGAGTCAGAGGTGTTGAAC
AGGCGCTCGTCGACGAGCGGGTCGTTGGAGACTACGTCATCCAAGGACATCCGCCAGATG
TCTCAACAGCAAGACTTGCTCAGTGCGCTCGTTAGCATGGAAAAGGTTCATGACTCTAGC
TCACAAATACTCCTTAAAAAACACAAGAGCAGCCACTGA
Protein Properties
Number of Residues 472
Molecular Weight 54091.9
Theoretical pI 4.93
Pfam Domain Function
Signals
  • ["None"]
Transmembrane Regions
  • ["91-111", "131-151", "158-178", "180-197", "217-237", "285-305"]
Protein Sequence 
>Cation channel sperm-associated protein 4
MRDNEKAWWQQWTSHTGLEGWGGTQEDRMGFGGAVAALRGRPSPLQSTIHESYGRPEEQV
LINRQEITNKADAWDMQEFITHMYIKQLLRHPAFQLLLALLLVINAITIALRTNSYLDQK
HYELFSTIDDIVLTILLCEVLLGWLNGFWIFWKDGWNILNFIIVFILLLRFFINEINIPS
INYTLRALRLVHVCMAVEPLARIIRVILQSVPDMANIMVLILFFMLVFSVFGVTLFGAFV
PKHFQNIQVALYTLFICITQDGWVDIYSDFQTEKREYAMEIGGAIYFTIFITIGAFIGIN
LFVIVVTTNLEQMMKAGEQGQQQRITFSETGAEEEEENDQLPLVHCVVARSEKSGLLQEP
LAGGPLSNLSENTCDNFCLVLEAIQENLRQYKEIRDELNMIVEEVRAIRFNQEQESEVLN
RRSSTSGSLETTSSKDIRQMSQQQDLLSALVSMEKVHDSSSQILLKKHKSSH
GenBank ID Protein 62988334
UniProtKB/Swiss-Prot ID Q7RTX7
UniProtKB/Swiss-Prot Entry Name CTSR4_HUMAN
PDB IDs Not Available
GenBank Gene ID NM_198137.1
GeneCard ID CATSPER4
GenAtlas ID CATSPER4
HGNC ID HGNC:23220
References
General References Not Available