Cannabis Compound Database: Showing Protein Cation channel sperm-associated protein 3 (CDBP02854)

Identification Biological properties Gene properties Protein properties External links References XML Show 1 compounds

Identification

HMDB Protein ID

CDBP02854

Secondary Accession Numbers

Not Available

Name

Cation channel sperm-associated protein 3

Description

Not Available

Synonyms

Ca(v)-like protein
CatSper3
One-repeat calcium channel-like protein

Gene Name

CATSPER3

Protein Type

Transporter

Biological Properties

General Function

Involved in ion channel activity

Specific Function

Voltage-gated calcium channel that plays a central role in sperm cell hyperactivation. Controls calcium entry to mediate the hyperactivated motility, a step needed for sperm motility which is essential late in the preparation of sperm for fertilization. Activated by intracellular alkalinization

GO Classification

Component
membrane
cell part
Function
transmembrane transporter activity
substrate-specific transmembrane transporter activity
ion transmembrane transporter activity
transporter activity
ion channel activity
Process
establishment of localization
transport
transmembrane transport
ion transport

Cellular Location

Multi-pass membrane protein
Cell projection
cilium
flagellum membrane

Pathways

Not Available

Gene Properties

Chromosome Location

Chromosome:5

Locus

5q31.1

SNPs

CATSPER3

Gene Sequence

>1197 bp
ATGTCTCAACACCGTCACCAGCGCCACTCGAGAGTCATTTCTAGTTCACCAGTTGACACT
ACATCGGTGGGATTTTGCCCAACATTCAAGAAATTTAAGAGGAACGATGATGAATGTCGG
GCATTTGTGAAGAGAGTCATAATGAGCCGTTTCTTTAAGATAATTATGATTAGCACTGTC
ACATCGAATGCGTTTTTTATGGCCTTGTGGACCAGTTATGACATAAGGTACCGCTTGTTC
AGACTTCTTGAGTTCTCGGAGATCTTCTTTGTGTCCATCTGCACATCTGAGTTGTCCATG
AAGGTCTATGTGGACCCCATCAACTACTGGAAGAACGGCTACAACCTGCTGGATGTGATC
ATTATCATCGTTATGTTTTTACCCTATGCCCTCCGCCAGCTCATGGGCAAACAGTTCACT
TACCTGTATATCGCTGATGGCATGCAGTCCCTGCGCATCCTCAAGCTTATCGGCTATAGC
CAGGGCATCCGGACGCTGATCACCGCCGTGGGGCAGACAGTCTACACCGTGGCCTCTGTG
CTCCTCCTGCTCTTCCTCCTCATGTACATCTTCGCTATCTTGGGCTTCTGCCTGTTTGGA
TCTCCAGACAATGGTGACCATGATAACTGGGGGAACCTGGCTGCGGCTTTTTTCACCCTC
TTCAGCTTGGCCACGGTTGATGGCTGGACAGACCTGCAGAAGCAGTTGGACAATCGGGAA
TTTGCTTTGAGCCGGGCATTCACCATCATCTTCATCTTGCTCGCCTCTTTCATCTTCCTC
AACATGTTCGTGGGTGTGATGATCATGCACACAGAGGACTCCATCAGAAAGTTTGAGCGA
GAGCTGATGTTGGAGCAGCAGGAGATGCTCATGGGAGAGAAGCAGGTGATTCTGCAGCGG
CAGCAGGAGGAGATCAGCAGGCTGATGCACATACAGAAAAATGCTGACTGCACAAGTTTC
AGTGAGCTGGTGGAGAACTTTAAGAAGACCTTGAGCCACACTGACCCAATGGTCTTGGAT
GATTTTGGCACTAGCTTACCCTTCATCGATATCTACTTTTCCACTCTGGACTACCAGGAC
ACAACTGTCCACAAGCTTCAAGAGCTGTACTATGAGATCGTGCATGTGCTGAGCCTAATG
CTGGAAGACTTGCCCCAGGAGAAGCCCCAGTCCTTGGAAAAGGTGGATGAGAAGTAG

Protein Properties

Number of Residues

398

Molecular Weight

46421.7

Theoretical pI

6.25

Pfam Domain Function

Ion_trans (PF00520 )

Signals

["None"]

Transmembrane Regions

["51-71", "79-100", "116-136", "142-161", "180-200", "249-269"]

Protein Sequence

>Cation channel sperm-associated protein 3
MSQHRHQRHSRVISSSPVDTTSVGFCPTFKKFKRNDDECRAFVKRVIMSRFFKIIMISTV
TSNAFFMALWTSYDIRYRLFRLLEFSEIFFVSICTSELSMKVYVDPINYWKNGYNLLDVI
IIIVMFLPYALRQLMGKQFTYLYIADGMQSLRILKLIGYSQGIRTLITAVGQTVYTVASV
LLLLFLLMYIFAILGFCLFGSPDNGDHDNWGNLAAAFFTLFSLATVDGWTDLQKQLDNRE
FALSRAFTIIFILLASFIFLNMFVGVMIMHTEDSIRKFERELMLEQQEMLMGEKQVILQR
QQEEISRLMHIQKNADCTSFSELVENFKKTLSHTDPMVLDDFGTSLPFIDIYFSTLDYQD
TTVHKLQELYYEIVHVLSLMLEDLPQEKPQSLEKVDEK

External Links

GenBank ID Protein

29468142

UniProtKB/Swiss-Prot ID

Q86XQ3

UniProtKB/Swiss-Prot Entry Name

CTSR3_HUMAN

PDB IDs

Not Available

GenBank Gene ID

AF432876

GeneCard ID