| Identification |
|---|
| HMDB Protein ID
| CDBP02851 |
| Secondary Accession Numbers
| Not Available |
| Name
| Calsyntenin-3 |
| Description
| Not Available |
| Synonyms
|
- Alc-beta
- Alcadein-beta
|
| Gene Name
| CLSTN3 |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| May modulate calcium-mediated postsynaptic signals. Complex formation with APBA2 and APP, stabilizes APP metabolism and enhances APBA2-mediated suppression of beta-APP40 secretion, due to the retardation of intracellular APP maturation |
| GO Classification
|
| Component |
| membrane |
| cell part |
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| calcium ion binding |
| Process |
| cell adhesion |
| cellular process |
| cell-cell adhesion |
| homophilic cell adhesion |
|
| Cellular Location
|
- Cell membrane
- Golgi apparatus membrane
- Endoplasmic reticulum membrane
- Single-pass type I membrane protein (Potential)
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 12p13.31 |
| SNPs
| CLSTN3 |
| Gene Sequence
|
>2871 bp
ATGACCCTCCTGCTGCTGCCCCTTCTGCTGGCCTCTCTGCTCGCGTCCTGCTCCTGTAAC
AAAGCCAACAAGCACAAGCCATGGATTGAGGCAGAGTACCAGGGCATCGTCATGGAGAAT
GACAACACGGTCCTACTGAATCCACCACTCTTTGCCTTGGACAAGGATGCCCCGCTGCGC
TATGCAGGTGAGATCTGCGGCTTCCGGCTCCATGGGTCTGGGGTGCCCTTTGAGGCTGTG
ATCCTTGACAAGGCGACAGGAGAGGGGCTGATCCGGGCCAAGGAGCCTGTGGACTGCGAG
GCCCAGAAGGAACACACCTTCACCATCCAGGCCTATGACTGTGGCGAGGGCCCCGACGGG
GCCAACACCAAGAAGTCCCACAAGGCCACTGTGCATGTGCGGGTCAACGATGTGAACGAG
TTTGCCCCAGTGTTTGTGGAACGGCTGTATCGTGCGGCTGTGACAGAGGGGAAGCTGTAC
GATCGCATCCTGCGGGTGGAAGCCATTGACGGTGACTGCTCCCCCCAGTACAGCCAGATC
TGCTACTATGAGATTCTCACACCCAACACCCCTTTCCTCATTGACAATGACGGGAACATT
GAGAACACAGAGAAGCTGCAGTACAGTGGTGAGAGGCTCTATAAGTTTACAGTGACAGCT
TATGACTGTGGGAAGAAGCGGGCAGCAGATGATGCTGAGGTGGAGATTCAGGTGAAGCCC
ACCTGTAAACCCAGCTGGCAAGGCTGGAACAAAAGGATCGAATATGCACCAGGTGCTGGG
AGCTTGGCTTTGTTCCCTGGTATCCGCCTGGAGACCTGTGATGAACCACTCTGGAACATT
CAGGCCACCATAGAGCTGCAGACCAGCCATGTGGCCAAGGGCTGTGACCGTGACAACTAC
TCAGAGCGGGCGCTGCGGAAACTCTGTGGTGCTGCCACTGGGGAGGTGGATCTGTTGCCC
ATGCCTGGCCCCAATGCCAACTGGACAGCAGGACTCTCGGTGCACTACAGCCAGGACAGC
AGCCTGATCTACTGGTTCAATGGCACCCAGGCTGTGCAGGTGCCCCTGGGTGGCCCCAGT
GGGCTGGGCTCTGGGCCCCAGGACAGCCTCAGTGACCACTTCACCCTGTCCTTCTGGATG
AAGCATGGCGTAACTCCCAACAAGGGCAAGAAGGAAGAGGAAACCATCGTATGTAACACT
GTCCAGAATGAGGACGGCTTCTCTCACTACTCGCTGACTGTCCACGGCTGTAGGATTGCC
TTCCTCTACTGGCCCCTGCTTGAGAGTGCCCGCCCAGTCAAGTTCCTCTGGAAGCTGGAG
CAGGTCTGTGATGATGAGTGGCACCACTACGCTCTGAACCTCGAGTTCCCCACAGTCACA
CTCTATACCGACGGCATCTCCTTCGACCCTGCCCTCATCCATGACAATGGCCTCATCCAC
CCACCCCGAAGGGAGCCTGCTCTCATGATTGGGGCCTGCTGGACTGAGGAGAAGAACAAA
GAGAAGGAAAAGGGAGACAACAGTACAGACACCACCCAAGGAGACCCTTTGTCGATCCAC
CACTACTTCCATGGCTACCTGGCTGGTTTCAGCGTGCGCTCAGGTCGCCTGGAGAGCCGC
GAGGTCATCGAGTGCCTCTATGCATGTCGGGAGGGGCTGGACTATAGGGATTTCGAGAGC
CTGGGCAAAGGCATGAAGGTCCACGTGAACCCCTCACAGTCCCTGCTCACCCTGGAGGGG
GATGATGTGGAGACCTTCAACCATGCCCTGCAGCATGTGGCTTACATGAACACTCTGCGC
TTTGCCACGCCCGGCGTCAGGCCCCTGCGCCTCACCACTGCTGTCAAGTGCTTCAGCGAA
GAGTCCTGCGTCTCCATCCCTGAAGTGGAGGGCTACGTGGTCGTCCTTCAGCCTGACGCC
CCCCAGATCCTGCTGAGTGGCACTGCTCATTTTGCCCGCCCAGCTGTGGACTTTGAGGGA
ACCAACGGCGTCCCTTTGTTCCCTGATCTTCAAATCACCTGCTCCATTTCTCACCAGGTG
GAGGCCAAAAAGGATGAGAGTTGGCAGGGCACAGTGACAGACACACGCATGTCGGATGAG
ATTGTGCACAACCTGGATGGCTGTGAAATTTCTCTGGTGGGGGATGACCTGGATCCCGAG
CGGGAAAGCCTGCTCCTGGACACAACCTCTCTGCAGCAGCGGGGGCTGGAGCTCACCAAC
ACATCTGCCTACCTCACTATTGCTGGGGTGGAGAGCATCACTGTGTATGAAGAGATCCTG
AGGCAGGCTCGTTATCGGCTGCGACACGGAGCTGCCCTCTACACCAGGAAGTTCCGGCTT
TCCTGCTCGGAAATGAATGGCCGTTACTCCAGCAATGAATTCATCGTGGAGGTCAATGTC
CTGCACAGCATGAACCGGGTTGCCCACCCCAGCCACGTGCTCAGCTCCCAGCAGTTCCTG
CACCGTGGTCACCAGCCCCCGCCTGAGATGGCTGGACACAGCCTAGCCAGCTCCCACAGA
AACTCCATGATACCCAGCGCCGCAACCCTCATCATTGTGGTGTGCGTGGGCTTCCTGGTG
CTCATGGTCGTCCTGGGCCTGGTGCGCATCCATTCCCTTCACCGCCGCGTCTCAGGGGCC
GGCGGGCCTCCAGGGGCCTCCAGTGACCCCAAGGACCCAGACCTCTTCTGGGATGACTCA
GCTCTCACCATCATTGTGAACCCCATGGAGTCCTACCAGAATCGGCAGTCCTGTGTGACG
GGGGCTGTTGGGGGCCAGCAGGAGGATGAGGACAGCAGTGACTCGGAGGTGGCCGATTCC
CCCAGCAGCGACGAGAGACGCATCATCGAGACCCCCCCACACCGCTACTAA
|
| Protein Properties |
|---|
| Number of Residues
| 956 |
| Molecular Weight
| 106096.6 |
| Theoretical pI
| 5.12 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Calsyntenin-3
MTLLLLPLLLASLLASCSCNKANKHKPWIEAEYQGIVMENDNTVLLNPPLFALDKDAPLR
YAGEICGFRLHGSGVPFEAVILDKATGEGLIRAKEPVDCEAQKEHTFTIQAYDCGEGPDG
ANTKKSHKATVHVRVNDVNEFAPVFVERLYRAAVTEGKLYDRILRVEAIDGDCSPQYSQI
CYYEILTPNTPFLIDNDGNIENTEKLQYSGERLYKFTVTAYDCGKKRAADDAEVEIQVKP
TCKPSWQGWNKRIEYAPGAGSLALFPGIRLETCDEPLWNIQATIELQTSHVAKGCDRDNY
SERALRKLCGAATGEVDLLPMPGPNANWTAGLSVHYSQDSSLIYWFNGTQAVQVPLGGPS
GLGSGPQDSLSDHFTLSFWMKHGVTPNKGKKEEETIVCNTVQNEDGFSHYSLTVHGCRIA
FLYWPLLESARPVKFLWKLEQVCDDEWHHYALNLEFPTVTLYTDGISFDPALIHDNGLIH
PPRREPALMIGACWTEEKNKEKEKGDNSTDTTQGDPLSIHHYFHGYLAGFSVRSGRLESR
EVIECLYACREGLDYRDFESLGKGMKVHVNPSQSLLTLEGDDVETFNHALQHVAYMNTLR
FATPGVRPLRLTTAVKCFSEESCVSIPEVEGYVVVLQPDAPQILLSGTAHFARPAVDFEG
TNGVPLFPDLQITCSISHQVEAKKDESWQGTVTDTRMSDEIVHNLDGCEISLVGDDLDPE
RESLLLDTTSLQQRGLELTNTSAYLTIAGVESITVYEEILRQARYRLRHGAALYTRKFRL
SCSEMNGRYSSNEFIVEVNVLHSMNRVAHPSHVLSSQQFLHRGHQPPPEMAGHSLASSHR
NSMIPSAATLIIVVCVGFLVLMVVLGLVRIHSLHRRVSGAGGPPGASSDPKDPDLFWDDS
ALTIIVNPMESYQNRQSCVTGAVGGQQEDEDSSDSEVADSPSSDERRIIETPPHRY
|
| External Links |
|---|
| GenBank ID Protein
| 42475534 |
| UniProtKB/Swiss-Prot ID
| Q9BQT9 |
| UniProtKB/Swiss-Prot Entry Name
| CSTN3_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| NM_014718.3 |
| GeneCard ID
| CLSTN3 |
| GenAtlas ID
| CLSTN3 |
| HGNC ID
| HGNC:18371 |
| References |
|---|
| General References
| Not Available |