| Identification |
|---|
| HMDB Protein ID
| CDBP02846 |
| Secondary Accession Numbers
| Not Available |
| Name
| Cornulin |
| Description
| Not Available |
| Synonyms
|
- 53 kDa putative calcium-binding protein
- 53 kDa squamous epithelial-induced stress protein
- 58 kDa heat shock protein
- Squamous epithelial heat shock protein 53
- Tumor-related protein
|
| Gene Name
| CRNN |
| Protein Type
| Metal Binding |
| Biological Properties |
|---|
| General Function
| Involved in calcium ion binding |
| Specific Function
| Survival factor that participates in the clonogenicity of squamous esophageal epithelium cell lines, attenuates deoxycholic acid (DCA)-induced apoptotic cell death and release of calcium. When overexpressed in oral squamous carcinom cell lines, regulates negatively cell proliferation by the induction of G1 arrest |
| GO Classification
|
| Function |
| ion binding |
| cation binding |
| metal ion binding |
| binding |
| calcium ion binding |
|
| Cellular Location
|
- Cytoplasm
|
| Pathways
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Chromosome:1 |
| Locus
| 1q21 |
| SNPs
| CRNN |
| Gene Sequence
|
>1488 bp
ATGCCTCAGTTACTGCAAAACATTAATGGGATCATCGAGGCCTTCAGGCGCTATGCAAGG
ACGGAGGGCAACTGCACAGCGCTCACCCGAGGGGAGCTGAAAAGACTCTTGGAGCAAGAG
TTTGCCGATGTGATTGTGAAACCCCACGATCCAGCAACTGTGGATGAGGTCCTGCGTCTG
CTGGATGAAGACCACACAGGGACTGTGGAATTCAAGGAATTCCTGGTCTTAGTGTTTAAA
GTTGCCCAGGCCTGTTTCAAGACACTGAGCGAGAGTGCTGAGGGAGCCTGCGGCTCTCAA
GAGTCTGGAAGCCTCCACTCTGGGGCCTCGCAGGAGCTGGGCGAAGGACAGAGAAGTGGC
ACTGAAGTGGGAAGGGCGGGGAAAGGGCAGCATTATGAGGGGAGCAGCCACAGACAGAGC
CAGCAGGGTTCCAGAGGGCAGAACAGGCCTGGGGTTCAGACCCAGGGTCAGGCCACTGGC
TCTGCGTGGGTCAGCAGCTATGACAGGCAAGCTGAGTCCCAGAGCCAGGAAAGAATAAGC
CCGCAGATACAACTCTCTGGGCAGACAGAGCAGACCCAGAAAGCTGGAGAAGGCAAGAGG
AATCAGACAACAGAGATGAGGCCAGAGAGACAGCCACAGACCAGGGAACAGGACAGAGCC
CACCAGACAGGTGAGACTGTGACTGGATCTGGAACTCAGACCCAGGCAGGTGCCACCCAG
ACTGTGGAGCAGGACAGCAGCCACCAGACAGGAAGAACCAGCAAGCAGACACAGGAGGCC
ACCAATGACCAGAACAGAGGGACTGAGACCCACGGTCAAGGCAGGAGCCAGACCAGCCAG
GCTGTGACAGGAGGACATGCTCAGATACAGGCAGGGACACACACCCAGACACCCACCCAG
ACCGTGGAGCAGGACAGCAGCCACCAGACAGGAAGCACCAGCACCCAGACACAGGAGTCC
ACCAATGGCCAGAACAGAGGGACTGAGATCCACGGTCAAGGCAGGAGCCAGACCAGCCAG
GCTGTGACAGGAGGACACACTCAGATACAGGCAGGGTCACACACCGAGACTGTGGAGCAG
GACAGAAGCCAAACTGTAAGCCACGGAGGGGCTAGAGAACAGGGACAGACCCAGACGCAG
CCAGGCAGTGGTCAAAGATGGATGCAAGTGAGCAACCCTGAGGCAGGAGAGACAGTACCG
GGAGGACAGGCCCAGACTGGGGCAAGCACTGAGTCAGGAAGGCAGGAGTGGAGCAGCACT
CACCCAAGGCGCTGTGTGACAGAAGGGCAGGGAGACAGACAGCCCACAGTGGTTGGTGAG
GAATGGGTTGATGACCACTCAAGGGAGACAGTGATCCTCAGGCTGGACCAGGGCAACTTG
CATACCAGTGTTTCCTCAGCACAGGGCCAGGATGCAGCCCAGTCAGAAGAGAAGCGAGGC
ATCACAGCTAGAGAGCTGTATTCCTACTTGAGAAGCACCAAGCCATGA
|
| Protein Properties |
|---|
| Number of Residues
| 495 |
| Molecular Weight
| 53533.3 |
| Theoretical pI
| 6.04 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
>Cornulin
MPQLLQNINGIIEAFRRYARTEGNCTALTRGELKRLLEQEFADVIVKPHDPATVDEVLRL
LDEDHTGTVEFKEFLVLVFKVAQACFKTLSESAEGACGSQESGSLHSGASQELGEGQRSG
TEVGRAGKGQHYEGSSHRQSQQGSRGQNRPGVQTQGQATGSAWVSSYDRQAESQSQERIS
PQIQLSGQTEQTQKAGEGKRNQTTEMRPERQPQTREQDRAHQTGETVTGSGTQTQAGATQ
TVEQDSSHQTGRTSKQTQEATNDQNRGTETHGQGRSQTSQAVTGGHAQIQAGTHTQTPTQ
TVEQDSSHQTGSTSTQTQESTNGQNRGTEIHGQGRSQTSQAVTGGHTQIQAGSHTETVEQ
DRSQTVSHGGAREQGQTQTQPGSGQRWMQVSNPEAGETVPGGQAQTGASTESGRQEWSST
HPRRCVTEGQGDRQPTVVGEEWVDDHSRETVILRLDQGNLHTSVSSAQGQDAAQSEEKRG
ITARELYSYLRSTKP
|
| External Links |
|---|
| GenBank ID Protein
| 5911314 |
| UniProtKB/Swiss-Prot ID
| Q9UBG3 |
| UniProtKB/Swiss-Prot Entry Name
| CRNN_HUMAN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| AF077831 |
| GeneCard ID
| CRNN |
| GenAtlas ID
| CRNN |
| HGNC ID
| HGNC:1230 |
| References |
|---|
| General References
| Not Available |